23/12/2025
** Monro-Kellie 4.0: ICP를 넘어 Intracranial Dynamics로
240년 된 Monro-Kellie doctrine이 4.0으로 업데이트되었습니다. 핵심은 "ICP is more than just a number" — 단순히 ICP 20-22mmHg 기준이 아니라, cerebrovascular autoregulation(CA), glymphatic system(GS), **intracranial compliance(ICC)**를 통합한 dynamic approach입니다. 특히 ICP가 정상이어도 compliance 저하와 brain hypoxia가 동반되는 "Intracranial Compartment Syndrome(ICS)" 개념이 제시되었습니다.
임상적으로는 P2/P1 ratio, RAP index 등 ICP-derived parameters와 함께, 응급실 단계부터 ONSD 초음파(>6mm), noninvasive ICP waveform(P2>P1), TCCD(PI>1.3), automated pupillometry(NPi
The Monro-Kellie doctrine, introduced in the late 18th century, was a groundbreaking concept aimed at explaining the interactions between intracranial volume components. It has since become a cornerstone of brain physiology, now recognized as intracranial dynamics. Initially, the doctrine focused on...