04/02/2019
Patient education: Endometrial cancer diagnosis and staging (Beyond the Basics)
INTRODUCTION — Endometrial cancer is a type of uterine cancer that involves the lining of the uterus (the endometrium). Endometrial cancer can occur in a woman of any age, although it is much more common after menopause.
THE UTERUS — To understand how endometrial cancer develops, it is helpful to understand the structure of the uterus. The uterus is a pear-shaped organ located between the bladder and the re**um. The cervix connects the uterus to the va**na. The inside of the uterus has two layers. The thin inner layer is called the endometrium. The thick outer layer is composed of muscle and is called the myometrium.
In women who menstruate, the endometrium thickens every month in preparation for pregnancy. If the woman does not become pregnant, the endometrial lining is shed during the menstrual period. After menopause, when menstrual periods stop, the endometrial lining normally stops growing and shedding. In women who have endometrial cancer, the uterine lining develops abnormal cells.
ENDOMETRIAL CANCER SYMPTOMS — The most common sign of endometrial cancer is abnormal va**nal bleeding.
ENDOMETRIAL CANCER DIAGNOSIS AND STAGING — Your doctor or nurse might recommend testing for endometrial cancer if you have abnormal bleeding. These tests take a sample of tissue from the lining of the uterus, called the endometrium. A doctor will examine the tissue with a microscope to see if there are signs of cancer.
Tumour staging — Once endometrial cancer is diagnosed; the next step is to determine its stage. Staging is a system used to describe the spread of a cancer. Endometrial cancer's stage is based on:
●How deeply the cancer has invaded the muscle wall of the uterus
●Whether there are signs that the cancer has spread to other organs on a physical exam, MRI of the abdomen and pelvis, chest X-ray, or other imaging tests
Endometrial cancer stages range from stage I (cancer has not invaded beyond the lining of the uterus) to stage IV (the cancer has spread to distant organs, such as the liver). In general, lower stage cancers are less aggressive and require less treatment than do higher stage cancers.
FACTORS THAT GUIDE TREATMENT OF ENDOMETRIAL CANCER — The treatment of endometrial cancer depends on how likely it is that the cancer will come back after treatment. This risk is based on:
●The stage of the cancer, which is based on what is found during surgery.
●How aggressive the tumour appears (called the tumour grade) when the tissue is examined under a microscope. High-grade tumours are usually faster growing and more likely to spread than low-grade tumours.
●What type of cells make up the tumour (called cell histology). Some cell types have a higher risk of coming back after treatment.
Depending on these characteristics, the cancer is said to have a low, intermediate, or high risk of coming back after surgery. These designations are used to decide which treatments, if any, are needed after surgery to decrease the risk of the cancer coming back.