Dr Bennani Mohamed Cardiologue Rythmologue à Casablanca

02/12/2025

02/12/2025

Do you wake up multiple times at night to p*e?

It’s one of the most COMMON kidney symptoms, yet most people don’t know why it happens:

❗ Peeing 2–4 times
❗ Feeling pressure
❗ Peeing small amounts
❗ Waking up tired in the morning
❗ Legs feeling heavy
❗ Incomplete emptying feeling

This is NOT “just aging.”
This is kidney-related night imbalance.

It happens because your kidneys struggle to manage:
👉 fluid shifting
👉 blood pressure changes
👉 nighttime filtration
👉 salt imbalance
👉 hormones that control urination

I created a simple guide that explains:
💚 Why night urination increases
💚 What it actually means
💚 And 4 gentle ways to reduce it

👉 Comment “LUMO” and I’ll send it to you privately.

Follow for more updates.

02/12/2025

Gene Therapy Approaches for Blood Disorders👇

✅This schematic illustrates the overall process of gene therapy used to correct hematopoietic stem and progenitor cells (HSPCs) in patients with β-thalassemia (Bthal) and sickle cell disease (SCD).

✅Autologous HSPCs are first harvested from the patient. These cells contain the genetic defects responsible for abnormal red blood cell (RBC) production.

✅The collected HSPCs are then processed ex vivo, where different gene therapy strategies are applied to correct the underlying mutations.

✅Four major gene-correction strategies are highlighted:
🔴i. Gene addition by lentiviral vectors (LV), which introduces a functional gene copy.
🔴ii. Homology-directed repair (HDR), a precise gene-editing method that uses a DNA template.
🔴iii. Non-homologous end-joining (NHEJ), an alternative editing pathway used for targeted DNA disruption or correction.
🔴iv. Base editing, which enables single-nucleotide corrections without double-strand breaks.

✅After correction, the modified HSPCs are reinfused into the patient. These cells repopulate the bone marrow and generate corrected red blood cells, improving or resolving disease symptoms.
💡 https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00492-6

02/12/2025

Authors demonstrate the potential of ALPK3 gene therapy as a novel treatment for ALPK3-related cardiomyopathy in a mouse model. https://ahajrnls.org/43C7jVr

01/12/2025

AORTIC REGURGITATION (AR) — ECHO BASICS

AR = backflow of blood Aorta → LV during diastole due to valve/root disease → leads to LV volume overload + dilation.

🩺 What to Evaluate on Echo

✔ Confirm AR
✔ Identify cause — Valve vs Aortic Root
✔ Assess morphology + regurgitation severity

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🔍 Key Echo Severity Markers

🔸 Jet Height / LVOT %
• 65% = Severe

🔸 Vena Contracta Width
• 500 ms = Mild
•

01/12/2025

Seminar on Risk Factors and Prevention by the European Association of Preventive Cardiology (EAPC) to improve your practice and prepare for your exams.

01/12/2025

Les articles du journal et toute l'actualité en continu

01/12/2025

Small cell lung cancer represents 10% to 15% of all lung cancers, and approximately 16 000 cases were diagnosed in the US in 2024.

📝 This JAMA Patient Page describes small cell lung cancer and its symptoms, diagnosis and staging, treatment, and prognosis.

https://ja.ma/48iYgu2

01/12/2025

Cancer rates among adults under age 50 years have been rising since the 1990s, according to recent research. Headlines and awareness campaigns about the risks of early-onset cancers — particular colorectal, a**l, and breast — are changing how people in their 30s and 40s think about prevention and are creating new challenges for primary care clinicians. http://ms.spr.ly/6183tnfXc