15/12/2025
What do you do when all your euploid embryos fail to implant? Well, there's some evidence that suggests we don't need to do anything differently, just keep transferring the remaining embryos, one will eventually stick.
Did I do that? Absolutely NOT ๐! Anyone who knows me, would know that I'd have ordered a string of tests for both, husband and wife.
And, we identified a few issues with:
1. Dad's s***m, minor issues
2. Mum's clotting factors
3. Mum's immune factors
4. Delayed endometrial receptivity window
5. Sub-optimal microorganism milieu in Mum's uterus
Here's their story:
โ Their 1st IVF in 2023 was at their previous centre, and they made 2 beautiful PGTA tested euploid embryos. Unfortunately both embryos failed to implant in 2 separate frozen embryo transfer (FET) cycles.
They then came over to see me at Sunfert@Bangsar South.
โ Their 2nd IVF was in June 2024. They decided to forgo PGTA testing this time round but agreed to some other tests that I wanted to carry out.
These results allowed us to modify their s***m selection technique in our embryology lab and, we added some extra culture steps for their embryos. Again, I remind you, the evidence for these techniques are not strong. Some might even call these 'tricks' of mine 'witchcraft' ๐โโฌ๏ธ ๐ ๐โโฌ๏ธ. Heck, I call it 'witchcraft' as well ๐งน๐งโโ๏ธ๐!
โ Their 1st FET at Sunfert@Bangsar South was in September 2024, with a non-PGTA tested, 3BB embryo. (Spoiler alert: Mum's already delivered the cutest baby boy ever, in May 2025)
This was the 'witchcraft' I tried in her 1st FET cycle with me:
ใI added some hormonal adjustments
ใI included some mild immune manipulation
ใShe agreed to anti-clotting factor treatment
ใWe corrected the imbalance in her microorganism milieu
ใWe dragged out her FET date to fit her implantation window
So, why do I keep practicing my brand of 'witchcraft' despite a lack of strong evidence? The answer is in this lovely picture: Another beautiful family completed!
Happy Mum, happy Dad, happy Jie Jie, happy Baby (baby was busy shaking his legs while we were trying to take this pic ๐คฃ), happy Doctor!