20/02/2026
Fresh from the press 📰🗞 the article “Hyaluronic Acid Profhilo® Alleviates Skin Inflammation and
Spinal Neuroimmune Alterations in a Mouse Model of Atopic Dermatitis” has been published in the journal Medicina, and it is already available online:
OVA-treated mice developed significant skin inflammation (p < 0.0001) and thermal hyperalgesia. Profhilo® injection significantly reduced SCORAD scores (p < 0.01) and mast cell density (p < 0.05) while increasing dermal thickness (p < 0.05). In the spinal cord, HA treatment reduced CGRP immunoreactivity and microglial activation (p < 0.01 and p < 0.05, respectively), especially in OVA-treated animals. Conclusions: Intradermal Profhilo® alleviated both cutaneous inflammation and neurogenic pain in an OVA-induced atopic dermatitis model. These findings suggest that Profhilo® not only improves local skin pathology but also modulates central neuroimmune responses, supporting its therapeutic potential for inflammatory skin conditions involving peripheral and central sensitization.
Read the full article at: https://www.mdpi.com/1648-9144/62/2/405/pdf