UIRRG

20/10/2024

Just published. Our latest paper on the development of Kir2.1 activators.

Background and Purposes Reduced inward rectifier potassium channel (Kir2.1) functioning is associated with heart failure and may cause Andersen-Tawil Syndrome, among others characterized by ventricu...

04/05/2024

We published a review on developments in Kir2.1 pharmacological tools

The functioning of the human heart relies on complex electrical and communication systems that coordinate cardiac contractions and sustain rhythmicity. One of the key players contributing to this intricate system is the KIR2.1 potassium ion channel, which is encoded by the KCNJ2 gene. KIR2.1 channel...

11/03/2023

Our latest paper on the influence of chronic propafenon application on Kir2.1 expressing cells

Expression and activity of inwardly rectifying potassium (KIR) channels within the heart are strictly regulated. KIR channels have an important role in shaping cardiac action potentials, having a limited conductance at depolarized potentials but contributing to the final stage of repolarization and....

25/01/2022

Our latest paper on Kir2.1 ion channel trafficking, and its dependence on the cytoskeleton, has just been published in Frontiers in Physiology.

Alteration of the inward rectifier current IK1, carried by KIR2.1 channels, affects action potential duration, impacts resting membrane stability and associates with cardiac arrhythmias. Congenital and acquired KIR2.1 malfunction frequently associates with aberrant ion channel trafficking. Cellular....

14/01/2022

We just published our latest work on the development of IKATP inhibitors. A good collaboration with our friends in Vienna.

Introduction: DEND syndrome is a rare channelopathy characterized by a combination of developmental delay, epilepsy and severe neonatal diabetes. Gain of function mutations in the KCNJ11 gene, encoding the KIR6.2 subunit of the IKATP potassium channel, stand at the basis of most forms of DEND syndro...

05/05/2021

Our latest review on the CAVB dog and its place in pharmacological research for over the last 100 years is now published open access.

Ventricular cardiac arrhythmia is a life threating condition arising from abnormal functioning of many factors in concert. Animal models mirroring human electrophysiology are essential to predict and...

04/09/2020

Our group member Muge defended her excellent thesis yesterday. We are very proud on the performance of Dr. Qile!

11/08/2020

We just published our work on the development of new Kir2 channel agonists, that we call AgoKirs.

https://www.mdpi.com/1422-0067/21/16/5746/htm

14/05/2020

Our work is on the cover page of Molecular Pharmacology

03/04/2020

Our work on Kv11.1 mistrafficking and its rescue by a combination of a corrector and activator is now published

Kv11.1 (hERG) channels play a critical role in repolarization of cardiomyocytes during the cardiac action potential (AP). Drug mediated Kv11.1 blockade results in AP prolongation, which poses an increased risk of sudden cardiac death. Many drugs, like pentamidine, interfere with normal Kv11.1 forwar...