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CombiBreed - English

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CombiBreed - English

Discover all about your pet with our genetic tests! From identifying breeds to disorders and traits.

28/04/2026

This combination package is designed to provide you with essential insights into your dog’s genetic health, traits and diversity, and includes DNA tests for a wide range of important diseases and/or traits. In addition, we also calculate your dog’s inbreeding coefficient (COI) and the percentage of heterozygosity in its DNA. The COI indicates the degree of inbreeding in your dog, whilst the heterozygosity percentage is a measure of your dog’s individual genetic diversity.

This test is available under test code: H320.

23/04/2026

Our customer service and laboratory will be closed on our national holiday, King’s Day. The swabs/hair bags for orders placed on 27 April will be sent out on Tuesday 28 April. Results that are normally processed on Mondays will now be processed on Tuesdays. Happy King’s Day!

21/04/2026

In horses, karyotyping is used to investigate the genetic causes of reduced fertility. Karyotyping makes it possible to visualise a cell’s entire set of chromosomes using a light microscope. To do this, blood cells are isolated and arranged in a karyogram. G-banding (Giemsa staining) makes chromosomes visible, allowing abnormalities such as trisomies, deletions, insertions, hermaphroditism and translocations to be identified.

Where chromosomal abnormalities are present, the karyogram can provide clear indications for further assessment and for taking targeted steps or breeding decisions.

This test is available under our test code: P335.

16/04/2026

MDR1 (Multi-Drug Resistance 1), also known as ivermectin sensitivity, is a condition in which cats may react severely to certain medicines and may even become poisoned. This is because the blood-brain barrier is compromised as a result of a recessive mutation in the ABCB1 gene. Medicines belonging to the P-glycoprotein substrate group, such as ivermectin, imidacloprid and selamectin, are particularly likely to cause problems. It is estimated that around 4% of domestic cats carry this mutation.

This test is available under test code: K423.

08/04/2026

Primary Open Angle Glaucoma (POAG) is an inherited eye disorder in which eye pressure gradually increases due to impaired drainage of fluid within the eye. In the Petit Basset Griffon Vendéen it is caused by a recessive mutation in the ADAMTS17 gene.
The condition usually develops around 3–4 years of age and shows few early symptoms. In later stages, affected dogs may develop redness, dilated pupils, corneal clouding, partial displacement of the lens (lens subluxation), and eventually vision loss or blindness.

This new test is available under test code H104.

07/04/2026

Congenital Stationary Night Blindness 2 (CSNB2) is a genetic retinal disorder that causes night blindness. It is caused by a mutation in the GRM6 gene, which normally transmits signals from the rod photoreceptors to the ON-bipolar cells in the retina. Although the eyes appear structurally normal, affected horses have difficulty seeing in low light or at night.
During the day, their vision is usually fine, but in dim or dark environments, they may hesitate, struggle to see obstacles, and face a higher risk of injuries. CSNB2 does not affect the structure of the eye, but it has a significant impact on their ability to function in low-light conditions.

This new test is available under test code P398.

06/04/2026

Ehlers-Danlos syndrome (EDS) is an inherited connective tissue disorder that affects the skin, joints, and blood vessels. Type 1 EDS, found in the Bengal breed, is caused by a mutation in the COL5A1 gene, which makes the skin fragile and the joints looser.
Cats with this condition have an increased risk of skin injuries, poor wound healing, and abnormal scarring. Other tissues, such as blood vessels, the heart, and eyes, can also be affected, sometimes leading to bruising or swelling. Symptoms usually appear within the first few months, and cats with mild forms have a normal life expectancy if properly cared for.

This new test is available under test code K485.

03/04/2026

Polymyositis is a muscle disease in which inflammation of the muscles can lead to difficulties with walking and swallowing. This disease has been identified in the Dutch Kooikerhondje and is influenced by two DNA mutations: PM1 and PM2.
Only dogs that are homozygous or heterozygous for PM1 can develop the disease. The risk is around 10% for homozygous dogs and approximately 2% for heterozygous dogs. If the PM2 mutation is also present, this risk increases by about 30%.
PM2 can now be tested together with PM1 using test code H107 and is also included in H561 CombiBreed Kooikerhondje – Fit2Breed and H506 CombiBreed Kooikerhondje.

This new test is available under test code H107.

02/04/2026

During Easter, our customer service team and laboratory will be closed. Swabs and hair samples for orders placed over the Easter weekend will be dispatched on Tuesday 7 April. Results that are normally processed on Mondays will now be processed on Tuesdays. Happy Easter! 🐣

11/03/2026

Ensure the genetic health of your breeding cats with our comprehensive DNA Health Package. This package provides an in-depth analysis of your cats genetic profile, offering valuable insights into health issues and hereditary traits. Screen for key hereditary conditions relevant to your breed, make informed pairing decisions, and support responsible breeding for a healthy future. A valuable tool for every dedicated cat breeder.

This test is available under test code: K500.

09/03/2026

Glycogen Storage Diseases (GSDs) are a group of metabolic disorders caused by defects in glycogen-processing enzymes. This test detects a mutation in the RBCK1 gene, linked to Polyglucosan Body Myopathy Type 1 (PGBM1) in Basset Hounds. The mutation leads to accumulation of abnormal glycogen (polyglucosan bodies) in muscle and cardiac tissue and is inherited in an autosomal recessive manner.

Affected dogs typically develop progressive muscle weakness, reduced exercise tolerance, and heart problems between 3 and 6 years of age. Cardiac glycogen buildup can cause cardiomyopathy, sometimes leading to sudden collapse or death. Early signs may be subtle, including lethargy, mild exercise intolerance, or respiratory difficulties.

This new test is available under test code H113.

06/03/2026

Cerebellar Ataxia (CA) is a hereditary neurological disorder affecting the cerebellum, the part of the brain responsible for coordination, balance, and fine motor control. In Flat-Coated Retrievers, a genetic variant disrupts normal neuronal function, impairing signal transmission between nerve cells and causing a gradual loss of coordinated movements. Affected dogs show typically loss of coordination (ataxia), a unsteady or “drunken” gait, head tremors, and difficulty with precise movements such as jumping, turning, or navigating stairs. Clinical signs usually appear in young puppies and progressively worsen over time.

This new test is available under test code H117.

Adres

Agro Business Park 100
Wageningen
6708PW

Openingstijden

Maandag	08:00 - 16:30
Dinsdag	08:00 - 16:30
Woensdag	08:00 - 16:30
Donderdag	08:00 - 16:30
Vrijdag	08:00 - 16:30

Telefoon

+31317416402

Website

https://www.combibreed.com/

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