Msc Medical Microbiology Trichandra College

02/01/2025

Dear all family member kindly requesting you all to like and follow my new page Micrbiology Explorer.

Microbiology Explorer refers to explores the world of microorganisms, often through research, education, exploration of microbial environments. This could be actively researching microbial life forms,scientific discovery within the field of microbiology,

04/05/2024

How do immune cells interact with fungi? 🔬What's new in the world of dengue virus vaccines? 💉

Find out in this week's ASM Journal Highlights! ✨⬇️

🧫The gut is the main reservoir for disseminated fungal infections. In this review, learn how specific immune cell types and effectors interact with fungi to limit their colonization or pathogenic potential. https://asm.social/1QN

🚰Researchers studied drinking water biofilms to reveal the impact of operational variations in pH and free chlorine concentration on the biofilm microbiome, as well as biofilm susceptibility to invasion by the coliform Serratia fonticola. : https://asm.social/1QO

🦠 Is everything everywhere? A new hands-on activity presented in engages undergraduates with fundamental microbial dispersal and biogeography concepts while also building quantitative reasoning and teamwork skills. https://asm.social/1QM

🦟Dengue virus infects 400 million people worldwide. A new virus-like particle vaccine induces high levels of neutralizing antibodies & reduces dengue replication in non-human primates, indicating it may be a promising vaccine candidate. : https://asm.social/1QL

🧬 The emerging pathogen Enterobacter cloacae expresses 2 type VI secretion systems (T6SS), which are directly activated by the major histone-like protein HU. Learn about the how this regulation affects T6SS-related phenotypes in : https://asm.social/1QK

Want more of the latest microbial sciences research? Stay tuned for the next !

01/05/2024

Microbiology Monday: What do Shigella, Listeria, Rickettsia and Burkholderia have in common?

They're all bacteria that spread intracellularly from cell to cell. The microbes alter the actin cytoskeleton of the host cell, which causes the cell membrane to protrude. Such protrusions poke into neighboring cells and blip off into vacuoles harboring bacteria. Once the bacteria emerge from the vacuole, additional rounds of intracellular spread can occur. Learn more about the bacterial and host factors involved in the protrusion process in : https://asm.social/1Q0

15/04/2024

What role do oral streptococci play in cancer?👄 How can bacterial chromosomal mutations for drive evolution of multi-drug resistance? 💊

Find out the answers to these questions and more in this week's ASM Journal Highlights, our weekly feature of some of the latest research published in ASM Journals! ⬇️

(1) This review explores how perturbation of oral streptococci biofilms may impact tumorigenesis, with potential therapeutic applications. https://asm.social/1O3

(2) In Pseudomonas aeruginosa, quorum sensing-regulated production of the blue-colored virulence factor, pyocanin, enhances bacterial resistance to ciprofloxacin. Learn more in : https://asm.social/1O1

(3) Growth in a skin-like medium (SLM) that strives to replicate the human skin environment stimulates expression of key virulence factors in Staphylococcus aureus, supporting SLM's use as an in vitro model for assessing bacterial metabolism on skin. : https://asm.social/1O2

(4) New research suggests bacteria carrying chromosomal mutations for antibiotic resistance may be better reservoirs for resistance plasmids, thus driving evolution of multi-drug resistance. : https://asm.social/1O4

(5) Proteus mirabilis needs urease to induce formation of urinary stones. In , researchers show that the transcriptional regulator UreR is the architect of urinary stone construction by regulating genes required to produce mature urease. https://asm.social/1O5

Stay tuned for more next week! 🦠

09/04/2024

Microbiology Monday: When viruses replicate, sometimes things go wrong. Aberrant viral replication can give rise to defective viral genomes (DVG). Incorporation of DVGs into virus particles forms defective particles that, through competition for viral proteins, interfere with replication of standard, infectious virus particles. As such, scientists are exploring how to capitalize on DVGs for antiviral therapeutics.

Learn more in : https://asm.social/1NB

02/04/2024

Microbiology Monday: The rare molds, Scedosporium species and Lemontospora prolificans, don’t cause infections often, but when they do it can be deadly. Within the host, the fungi germinate to produce hyphae. These branched structures pe*****te host macrophages—ultimately killing the infection-fighting cells—and go on to infiltrate blood vessels. When this happens, the fungi can disseminate throughout the body and cause severe disease.

Learn more about these difficult-to-treat infections in :
https://asm.social/1MH

29/03/2024

Microbiology Monday: Biofilm formation and multi-drug resistance (MDR) often go hand-in-hand. Both of these processes are complex, regulated by various genetic pathways. At one point, studying essential genes within those pathways was a challenge. However, the advent of CRISPRi technology changed that. By allowing knockdown of essential genes, CRISPRi has enabled discovery of once-uncoverable antimicrobial and biofilm targets to combat both bacterial and fungal pathogens.

Learn more in : https://asm.social/1M2

20/11/2023

What must be considered when engineering bacteria to be alternatives to antibiotics? 🧬How do burn wounds increase bacterial pathogenicity? 🩹

Find the answers in this week's ! 👇

☑️Using probiotic bacteria to make antibiotic-like compounds is emerging as an alternative to conventional antibiotic treatment. What must be taken into account when engineering bacteria for therapeutic, prophylactic or diagnostic applications? : https://asm.social/1zX

☑️A fatty acid derived from a marine bacterium shows antibacterial effects against gram-positive bacteria by destabilizing the cell membrane. The compound could be used as an adjuvant to enhance antibiotic susceptibility. : https://asm.social/1zW

☑️Researchers find that a combination of burn wound injury and Pseudomonas aeruginosa infection elicits gene expression that enhances bacterial pathogenicity. : https://asm.social/1zT

☑️A new study in provides an expanded toolkit of drug resistance cassettes for Candida pathogens, thus increasing the versatility of genetically modifying complex pathways involved in drug resistance and pathogenesis. https://asm.social/1zV

☑️The novel bacteriocin romsacin from Staphylococcus haemolyticus inhibits gram-positive World Health Organization priority pathogens, including MRSA and vancomycin-resistant enterococcus. Read the article in : https://asm.social/1zU

12/11/2023

Despite their reputation as agents of disease, bacteria can also play protective roles in wound healing and may even be leveraged to improve medical outcomes.

11/11/2023

How does Klebsiella pneumoniae colonize the gut? 🤔 Can biosensors detect the antimicrobial activity of medicinal plant extracts? 🌱

Find out in this week's ASM Journal Highlights!

☑️ The central dogma (CD) of molecular biology can be challenging to understand. 🧠This lab exercise uses mutant chromogenic protein and informational suppressor E. coli strains to help students grasp the role of translation in the CD. : https://asm.social/1z6

☑️ A biosensor approach detects outer membrane (OM)-specific antimicrobial activity of fungal cultures & medicinal plant extracts against Pseudomonas aeruginosa. 🦠 : https://asm.social/1z4

☑️Bacterial imbalance and dysfunction may be a potential micro-ecological mechanism underlying coral bleaching, which causes enormous physiological damage to corals. 🪸 : https://asm.social/1z8

☑️ This study identifies a core gut colonization program for the K. pneumoniae, as well as detects strain-to-strain differences in colonization strategies.🔬https://asm.social/1z5

☑️Histone acetylation modification (one of several histone modifications that affect gene expression in eukaryotes) impacts the sexual life cycle of the high-risk human fungal pathogen, Cryptococcus neoformans. 🧬https://asm.social/1z7

25/10/2023

Vibrio vulnificus, a so-called “flesh-eating bacterium,” causes severe wound infections. What are the mechanisms behind its ability to destroy host tissues—and why does it destroy them at all?