Gillies McIndoe Research Institute

26/11/2025

Have you ever wondered what Gillies McIndoe data might sound like as a techno beat? 🎶🧬

Our PhD student, Dr. Sam Siljee (pictured below dressed as his favourite lab equipment - the Mass Spectrometer), has created an original techno track using sounds generated entirely from his own research data.

While analysing mass spectrometry data for his PhD, Sam developed a method to transform raw spectral information into soundscapes. Every synthesiser in this track is built from tones produced by real protein data, including some of his favourites like ATP synthase and histones. The percussion in this track still comes from classic electronic music samples.

🔊 Listen to it here: https://soundcloud.com/samsiljee/c7f942fd-792d-4276-bcfc-bcf8df7dba23

For his next piece, Sam plans to weave in audio clips recorded from instruments and equipment around the lab - truly turning science into sound (also pictured below). Stay tuned!

It’s one of the most creative ways we’ve seen science come to life, and a meaningful way to honour the patients whose donated tissues make this research possible. 💙

24/11/2025

We’re so proud of our PhD students Jasmine (Jaz) White and Clara López, who attended the Society for Neuro-Oncology (SNO) Annual Meeting in Hawaii, succeeding in securing funding from Te Herenga Waka—Victoria University of Wellington and University of Otago for the journey.

🔬 Jaz shared her research on why some glioblastoma neurospheres resist treatment to chemotherapy and radiation, pinpointing the molecular pathways driving resistance.

🔬 Clara presented her work which characterised hormonal and s*x differences using two types of patient-derived meningiomas, highlighting pathways which may guide treatment decisions.

We’ve been supporting them from home and love celebrating where their research takes them. 💙

20/11/2025

We’re celebrating our Research Fellow, Dr. Alex Chan, on the successful publication of his latest paper:
“Distinct profiles of mitochondrial bioenergetics and redox balance in left atrial and ventricular myocardium in the healthy rat heart.” 💙🐀

🔍 What was this study about?
Mitochondria live inside our cells and turn oxygen and sugar into usable energy - a process called respiration. In doing so, they also release various byproducts.

This study explored how those mitochondrial outputs differ between two chambers of the heart: the left atrium (upper chamber) and the left ventricle (lower chamber) in healthy rat hearts.

✨ What did the team discover?
The left ventricle showed a higher mitochondrial respiratory capacity per tissue mass, but lower function when adjusted for mitochondrial content compared with the left atrium.
These chamber-specific differences highlight why it’s so important to study each region of the heart separately when trying to understand both healthy function and disease.

We are incredibly proud of you, Alex! 💙

📄 Read the full paper: https://doi.org/10.1113/EP093102

18/11/2025

We’re excited to share that our available laboratory space at the Gillies McIndoe Research Institute has now been filled.

This collaboration reflects the growing trust in the specialist research environment we’ve built here in Gillies McIndoe. At Gillies McIndoe, we’re proud to collaborate with local and national researchers, helping advance science and discovery for our collaborators and partners. While the lab space is no longer available, we continue to offer a suite of specialist research services, including:

🔬 Cell-based assays
🧫 Histology services
🧬 Tissue bank services

Learn more about our capabilities here👉 https://lnkd.in/gvq62K6E

📍 Based in Wellington | Open to partnerships | Focused on discovery

18/11/2025

Congratulations to Erin Paterson of the Gillies McIndoe Research Institute, New Zealand, who has been nominated by Dr Clint Gray and others in the Awards! 🏆

Read Erin's nomination and tell us about the life science superstars in YOUR lab: https://ow.ly/GuXJ50XsRfg

13/11/2025

A huge thank you to Rotary Club of Plimmerton , our community champions! 💙

Through their incredible Garden Tour, they raised $14,000, with $7,000 generously donated to the Gillies McIndoe Research Institute.

At Gillies, every dollar donated is used to fuel the engine that keeps our research moving forward and enables the freedom to explore bold approaches; from repurposing existing medicines to discovering safer, more effective treatments for cancer and related diseases.

We are deeply grateful to the Rotary Club of Plimmerton members, everyone who organised this wonderful event, all those who thought of us when choosing where to donate, the generous homeowners who opened their gardens, and everyone who attended and supported the tour. Your collective effort made this event truly blossom. 🌸

Congratulations again to Jennie Wright, winner of our Garden Lover Gift Basket! And a special thank you to everyone who donated the beautiful items inside, your kindness helped raise awareness for the important research we do at Gillies McIndoe.

With appreciation to Anita Baker - Mayor of Porirua City for generously sharing Photo 1.

12/11/2025

10/11/2025

We thought we’d have a bit of fun today at Gillies McIndoe! 🧬✨

We challenged some of our team members to describe their research in fifteen words or less! It wasn’t easy, but we think they did an exceptional job. 👏

Now it’s your turn! Could you summarise what you do in just 15 words?
Drop your best attempt in the comments below! 💬👇

04/11/2025

🌿🔬 What a weekend at the Plimmerton Rotary Garden Tour!
We had a wonderful time meeting all of you, chatting about our research, and enjoying the beauty of the garden around us. 💙🦋
And we even had a stunning tūī strike a pose just for us! 🐦✨

🎉 Congratulations to Jennie Wright — winner of our Garden Lover Gift Basket!
Everyone else is still a winner for enjoying the beautiful weather with us… better luck next time! 😉🌸

We are incredibly grateful to the Rotary Club of Plimmerton for inviting us to be part of this fantastic community event — and for generously donating some of the net proceeds to support our life-changing research. Your support means the world to us. 💙🙌

We also want to acknowledge our incredible PhD and Masters students who took time away from the lab to share just how cool science really is. You represent the future of research — and we couldn’t be prouder! 🔬✨

Together, we’re raising awareness of our work in:
• Strawberry birthmarks (infantile haemangioma)
• Keloid scars & fibrosis
• Brain tumours including glioblastoma & meningioma
• Drug repurposing for safer, smarter therapies

Your support helps science grow — right here in Aotearoa 🌱

30/10/2025

If you caught our last post, you’ll know we’re so excited to be part of the Rotary Club of Plimmerton Garden Tour! 🌿🌸
And we’ve got another reason for you to stop by and say hello… 👋

Sign up for our newsletter at the start of the tour in Aotea and you’ll go in the draw to WIN a $250 garden gift basket full of treats for plant lovers! 🎁🌼
Don’t miss your chance to chat about our research and see 10 wonderful gardens— get your tickets now through Rotary Club of Plimmerton 👉 https://www.plimmertonrotary.org.nz/garden-tour-2025

🌸

Terms and Conditions: Open to NZ residents 18+ who sign up for the Gillies McIndoe newsletter at the Plimmerton Garden Trail on 1–2 Nov 2025. One entry per person. Prize is non-transferable, not redeemable for cash, and must be delivered to a NZ address. Winner drawn 5 Nov 2025 and announced on Facebook and Instagram; if the winner can’t be contacted within one week, a new winner may be drawn. Entries become property of Gillies McIndoe and may be used for promotional purposes. Personal information will be managed under the Privacy Act 2020 (contact info@gmri.org.nz)

29/10/2025

Gillies McIndoe researchers to present at international neuro-oncology meeting

PhD students Jasmine (Jaz) White and Clara López from the Gillies McIndoe Research Institute will attend the Society for NeuroOncology Meeting in Hawaii from 19-23 November, supported by funding from Te Herenga Waka—Victoria University of Wellington and the University of Otago respectively.

Jaz will present a poster outlining research showing how patient-derived glioblastoma neurospheres respond differently to temozolomide and radiation treatment. Her work identifies treatment-resistant subgroups and reveals mechanisms such as metabolic reprogramming and oxidative-stress evasion, offering insights into potential biomarkers and therapeutic targets to overcome chemoradiation resistance.

Clara's poster presentation explores the hormonal and s*x-specific influences on drug metabolism in patient-derived meningiomas. Her findings suggest that oestrogen and cholesterol-related pathways may drive subtype and s*x differences in tumour biology.



PhD students Jasmine (Jaz) White, left, and Clara López. Photo montage: Gillies McIndoe.

27/10/2025

There’s nothing quite like unboxing new lab equipment to spark excitement for science! 🧪
We’re welcoming our new Microplate Reader from Thermo Fisher Scientific - ready to support the next wave of research. 💙🔬