Physical Medicine & Rehabilitaion Bontoc General Hospital

25/02/2025

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A two-and-a-half-year-old girl has become the first person treated for spinal muscular atrophy (SMA) before birth, showing no symptoms of the severe motor-neuron disease.

Her mother took the gene-targeting drug Risdiplam during late pregnancy, a groundbreaking approach approved by the FDA for this case. The child continues to take the drug post-birth.

This breakthrough suggests in-utero treatment could prevent SMA symptoms before they develop, potentially transforming future approaches to genetic disorders.

29/07/2022

05/06/2022

26/04/2022

😎 Disc protrusion completely resolves on its own!

👋🏻 Here's a case report of a 28 year old with severe back and leg pain

📸 MRI November 2018 showed “Large L4/5disc protrusion w severe cord narrowing/ crowding of cauda equina rootlets”....

🕒 7 months later and a new round of imaging

📸 MRI May 2019 showed reabsorption and now pain free! 😱

➡️ This is a great example of conservative Mx & ‘watch & wait’ approach. We don't know exactly what his treatment consisted of, but we know from the research that disc problems resolve on their own

📚 A meta-analysis (Zhong et al 2017) has shown that 2/3 of disc bulges spontaneously «heal» on their own! Many of them within a few months too, not years

❌ This does not mean that no one should ever undergo surgery. Each patient must be managed on an individual basis

🙌🏻 Thanks to Dan Board for bringing this case to our attention.