20/06/2022
Diabetes ➡️ Sakit sa Puso
Kung may time kayong magbasa, nasa baba ang ilang mga importanteng literature at scientific studies. Kung walan naman, i summarize ko na.
Dalawa lang:
1️⃣. Kung ayaw mong magkasakit sa puso, huwag maging diabetic
2️⃣. At kung nagising ka sa isang umaga na may diabetes at sakit sa puso ka na, mag Ketogenic Diet agad.
✔️From Dr. Joseph Kraft :
“Cardiovascular disease complications are the leading cause of morbidity and mortality in people with diabetes. Diabetes increases the development of cardiovascular disease up to fivefold. As many as 80 percent of patients with type 2 diabetes die from cardiovascular complications. Cardiovascular disease in diabetes mellitus consists mainly of coronary artery disease with or without infarction, congestive heart failure, and idiopathic cardiomy-opathy. Diabetes, the most common endocrine disorder, had an estimated global prevalence of 140 million adults in 1997.”
✔️"The risk of myocardial infarction (MI) is 3-5 fold higher in Type 2 DM and a DM subject with no history of MI has the same risk as a non-DM subject with a past history of MI. In total around 70% of deaths are vascular with poorer outcomes to both acute events and cardiological interventions.
https://pubmed.ncbi.nlm.nih.gov/17645584/
✔️The accelerated development of atherothrombotic cardiovascular disease in type 2 diabetes mellitus may be enhanced by the presence of a prothrombotic state. This prothrombotic state includes a diminished fibrinolytic capacity and an increased coagulability. Impaired fibrinolytic capacity appears to be a hallmark of the metabolic syndrome of type 2 diabetes and can be a direct consequence of visceral obesity.
https://pubmed.ncbi.nlm.nih.gov/16222598/
✔️This review is focused on the factors and potential mechanisms that are causing various cardiovascular pathologies. In diabetes, insulin's actions on the endothelium and other vascular cells have significant influence on systemic metabolisms and the development of cardiovascular pathologies. Our studies showed that insulin receptors on the endothelium are important for insulin transport across the endothelial barrier and mediate insulin's actions in muscle, heart, fat, and the brain.
https://pubmed.ncbi.nlm.nih.gov/27222390/
✔️The effects of diabetes on atherosclerosis appear to be dependent on an interplay between glucose and lipids, as well as other factors, and result in increased recruitment of monocytes into both progressing and regressing lesions of atherosclerosis. Importantly, some of the mechanisms revealed by mouse models are now being studied in human subjects. This Perspective highlights new mechanistic findings based on mouse models of diabetes-exacerbated atherosclerosis and discusses the relevance to humans and areas in which more research is urgently needed in order to lessen the burden of macrovascular complications of type 1 and type 2 diabetes mellitus.
https://pubmed.ncbi.nlm.nih.gov/26207031/
✔️A major consequence of diabetes mellitus type 2 is the accelerated development of atherosclerosis. Assessment of conventional risk factors such as plasma lipids, lipoproteins and hypertension only partly account for the excessive risk of developing cardiovascular disease in this population. Increasing evidence has emerged suggesting that conditions associated with diabetes mellitus type 2, such as insulin resistance, hyperinsulinemia and hyperglycemia, may also play a significant role in regulating 'novel' cardiovascular risk factors. These factors and their potential roles in the development of atherosclerosis and cardiovascular events are discussed in this review.
https://pubmed.ncbi.nlm.nih.gov/11048895/
✔️Subjects characterized by a predominance of small LDL particles (pattern B) have changes in plasma triglyceride (TG) and HDL-cholesterol concentrations consistent with the presence of resistance to insulin-mediated glucose uptake. Pattern B subjects are insulin resistant, have higher glucose, insulin, and TG, lower HDL-cholesterol levels, and higher blood pressure than those with pattern A or intermediate.
https://pubmed.ncbi.nlm.nih.gov/8325978/
✔️The Very-Low Carb-Ketogenic diet(VLCKD) showed beneficial changes in body composition and cardiometabolic markers in eutrophic and overweight participants in a 140-day study suggesting a future role for this diet in populations at cardiovascular disease risk.
https://pubmed.ncbi.nlm.nih.gov/34918971/
✔️The findings of a multi-center Very-Low Carb-Ketogenic diet(VLCKD) program conducted in a real-world setting in a cohort of overweight/obese women indicate that it is safe and effective, as it results in a major improvement of cardiometabolic parameters, thus leading to benefits that span well beyond the mere body weight/adiposity reduction.
https://pubmed.ncbi.nlm.nih.gov/34073344/
I wish you Health ♥️
Thanks to: Mr. Jeff Cyr
Disclaimer: This information is for educational purposes only, including all my comments, suggestions, and opinion. It is not practise of medicine, and is not intended as a substitute for medical diagnosis or treatment. You should not use this opinion or general information to diagnose or treat your health problem or condition. Please always consult with your doctor.
