10/02/2026
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Trimetazidine is a prescribed metabolic oral medication used to treat angina pectoris through the support of myocardial glucose utilization during ischemic-related conditions. It partially reduces fatty acid beta oxidation, therefore lessening chest pain
Trimetazidine functions through its anti-ischemic properties by inhibiting fatty acid beta oxidation, specifically blocking the 3-ketoacyl-CoA thiolase in the mitochondria. This results in a shift to glucose oxidation, or glycolysis, in cardiac metabolism in order to restore ATP production in oxygen-deprived cells.
Common side effects tend to include dizziness, headaches, stomach pain, diarrhea, indigestion and vomiting, with more severe side effects pertaining to rashing, itching, hives, and a general feeling of weakness.
References:
WebMD. (n.d.). What is trimetazidine? WebMD.
https://www.webmd.com/heart-disease/what-is-trimetazidine
DrugBank Online. (n.d.). Trimetazidine (DB09069).
https://go.drugbank.com/drugs/DB09069
ScienceDirect. (n.d.). Trimetazidine. Elsevier.
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/trimetazidine
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