19/12/2025
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Dofetilide is a medication used to help correct irregular heart rhythms, especially in patients with atrial fibrillation and atrial flutter. It is prescribed to restore the heartbeat back to a normal, steady rhythm and supports long-term rhythm control. As a Class III antiarrhythmic drug, dofetilide works by blocking a specific potassium channel (IKr) involved in cardiac electrical activity. This action prolongs the heart’s action potential and refractory period, helping slow abnormal electrical impulses and stabilize heart rhythm.
Because Class III antiarrhythmic drugs significantly affect the heart’s electrical timing, dofetilide can increase the risk of serious arrhythmias if not carefully monitored. For this reason, treatment is started in the hospital, where patients are required to stay for at least 3 days for close ECG monitoring and safe dose adjustment. Dosing is individualized and depends on the patient’s condition and response, so doses should never be changed unless directed by a healthcare provider. Moreover, some medications should not be taken with dofetilide, so patients must inform their healthcare provider about all medicines they are using.
Dofetilide is available by prescription only and requires regular follow-up to ensure safe and effective treatment. Patients should attend scheduled ECGs and laboratory tests, review medication information with each refill, and report any side effects or health changes to their healthcare provider.
References:
https://go.drugbank.com/drugs/DB00204
https://www.mayoclinic.org/drugs-supplements/dofetilide-oral-route/description/drg-20063516
https://my.clevelandclinic.org/health/drugs/16936-dofetilide-antiarrhythmic-medication
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https://go.drugbank.com/drugs/DB00204
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