21/01/2026
Jujutsu Kaisenโs third season is set in an apocalyptic Japan where the sorcerers are gathered to fight in a battle royale. Because of this, lives have been lost, and countless injuries have been incurred, and the healers are constantly exhausted due to their excessive use of the Reverse Cursed Technique (RCT)โthe conversion of cursed energy to positive energy to rapidly heal injuries and regenerate flesh. Fortunately, such gruesome events are nowhere to be found in our reality, but the lives that have been lost due to our technological limitations are still increasing. With limits in mind, advancements in nanotechnology have shown promising results in the preclinical stage of accelerated wound care - just like RCT!
Witness how nano-biomaterials turn fiction into reality in this weekโs Wisdom Wednesday!
Open wounds such as cuts, abrasions, and burns, or deep wounds like lacerations and punctures, are usually treated with first aid to stop the bleeding, disinfect the area, and cover it to prevent further injury. With that, most of the healing is actually done by the natural wound-healing responses of our bodies, which involve four major phases.
First is Hemostasis. Wounds bleed out because of damaged blood vessels, and the immediate response of the body is to restrict blood flow through vasoconstriction, platelet plugs, and the coagulation cascade - resulting in the formation of fibrin clots. In some people, bleeding disorders like Hemophilia slow down hemostasis due to low levels of these clotting factors. This is why specific treatments for wound care involve the use of silk fibroin nanofiber scaffolding functionalized with Zinc Oxide nanoparticles. Furthermore, nanogels with chitosan nanoparticles cover a wider surface area for platelet adhesion and elevate the number of clotting factors. Together, these nanostructures accelerate hemostasis, preventing further blood loss.
Once the bleeding has stopped, our body proceeds to the next phase: Inflammation. Blood vessels dilate to promote blood flow, which is the reason why our wounds show redness, swelling, and sometimes feel hot. This is to bring immune cells, which are primarily white blood cells (leukocytes), to rid the affected area of contaminants and microbes that could cause infection. Using nanocarriers, such as liposomes and dendrimers, the delivery of antimicrobial peptides is improved by directly targeting infected tissues - reducing systemic toxicity. In chronic wounds, the use of nano-enzymes can more effectively help disinfect the wound because these materials can dismantle and pe*****te the protective biofilm of most bacteria. These techniques ensure that the healing process is unbothered.
Ryลiki Tenkai: Nanostructures of Life
The third phase of wound healing is called Cell Proliferation, and this is where โRCTโ is at its peak. As the name suggests, the proliferation stage includes the formation of new blood vessels (Angiogenesis), extracellular matrices, and the migration of keratinocytes to close wound surfaces. All of these are made possible by coordinated cell growth and division, with the help of new muscle cells (Myofibroblasts) for producing and organizing collagen. To accelerate the regeneration process, biomimetic nanofiber scaffolds derived from graphene and collagen provide a foundation for the extracellular matrix- the bulk of the damaged area - acting as a substrate for cellular attachment, migration, and growth. Simultaneously, cellulosic nanostructures with polymeric nanoparticles are essential for the sustained localized delivery of growth factors to the healing wound. Reinforcing the wound with nanostructures that aid in regeneration also provides the affected area with greater stability once healed, which is vital for the final phase.
Lastly, the healed wound enters the Remodeling Phase. During this phase, collagen fibers undergo cross-linking to increase tissue tensile strength. Simultaneously, myofibroblasts undergo apoptosis, reducing scar contraction. As a result, newly formed tissue structures reorient and mature, allowing the tissue to better tolerate mechanical stress. Tissue regeneration with the aid of anti-fibrotic agents delivered by nanocarriers helps reduce scarring by limiting the activity of myofibroblasts. In addition, controlled collagen delivery can also be achieved using polymeric or carbon-based nano-scaffolds, which influence growth factor delivery and shifting of inflammatory activity to regenerative activity. Over time, the artificial materials get integrated in the body as if being recognized as its own.
Much like Satoru Gojoโs cursed technique, the application of nanomaterials is virtually โlimitlessโ. In the medical field, some physiological anomalies cannot be resolved using conventional treatments, and often, the tiniest solutions can have the biggest impact on a patientโs life. It is important to note that while early studies deliver these results, normalizing this technique now is impractical because it involves an exorbitant amount of money, and needless to say, the materials involved may have selective biocompatibility with various people.
Until all technological hurdles are crossed, healing injuries instantly remains a work of fiction.
Content by: Hans Neoncris Hofileรฑa
Design by: Sebastian Estandarte
Are you ready to be WEISS-er? Access our references to learn more at tinyurl.com/upmssWW
Wisdom Wednesday is brought to you by the UP Materials Science Society. Want more knowledge? Stay tuned next week for another amazing Wisdom Wednesday!
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