09/04/2026
Chlorhexidine gluconate is a widely used antiseptic and antimicrobial agent designed to kill bacteria, fungi, and some viruses. It is heavily used for skin disinfection before surgeries, treating gingivitis via oral rinses, and cleaning wounds. It works by disrupting bacterial cell membranes, generally reducing microbial skin flora.
Key Uses of Chlorhexidine Gluconate
Oral Hygiene: Prescription-strength mouthwash (typically 0.12%) is used to treat gingivitis, reduce gum inflammation, and treat oral yeast infections.
Skin Antiseptic: Used as a surgical scrub, hand wash, and for skin preparation before surgeries to prevent infections.
Wound Care: Used to clean skin wounds and sometimes in managing infections.
Common Forms
Oral Rinse/Mouthwash: Used for treating gingivitis.
Skin Liquid/Solution/Soap: Used for antiseptic skin cleansing and pre-op prep.
Topical Creams/Sprays: Used for wound hygiene.
Side Effects
Oral Rinse: Staining of teeth and tongue, taste changes (including a bitter taste), and increased tartar build-up.
Topical Use: Potential for skin irritation, and rarely, severe allergic reactions (anaphylaxis). It should not be used on open, deep, or packed wounds.
Important Information
Usage: For oral rinses, it should generally be used after brushing, rinsed for 30 seconds, and then spat out (do not swallow).
Interactions: Some toothpastes can deactivate chlorhexidine, so it is recommended to brush, rinse thoroughly, and then use the oral rinse.
Precautions: Avoid contact with eyes and ears.
