17/02/2024
TAB PARQIN 20MG RS 295
Piroxicam-Ξ²-Cyclodextrin is a pharmaceutical formulation that combines piroxicam, a nonsteroidal anti-inflammatory drug (NSAID), with Ξ²-cyclodextrin, a cyclic oligosaccharide. This combination is designed to improve the solubility and bioavailability of piroxicam.
Here's a breakdown of its description and uses:
1. **Description**: Piroxicam-Ξ²-Cyclodextrin is a complex formed by the inclusion of piroxicam molecules within the Ξ²-cyclodextrin cavity. Cyclodextrins are a family of cyclic oligosaccharides composed of glucose units, which can form inclusion complexes with hydrophobic molecules like piroxicam. This complexation enhances the solubility of piroxicam in aqueous solutions, improving its bioavailability and potentially reducing gastrointestinal side effects associated with the drug.
2. **Uses**:
- **Anti-inflammatory**: Piroxicam is a potent NSAID primarily used to reduce inflammation, pain, and swelling associated with various conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and gout.
- **Analgesic**: It also possesses analgesic properties, making it useful in managing mild to moderate pain.
- **Antipyretic**: Piroxicam can help reduce fever, although it's not commonly used for this purpose.
- **Improvement in Bioavailability**: By forming a complex with Ξ²-cyclodextrin, the bioavailability of piroxicam is enhanced. This means that more of the drug reaches the systemic circulation, potentially leading to improved therapeutic outcomes with lower doses and reduced side effects.
3. **Administration**: Piroxicam-Ξ²-Cyclodextrin is typically administered orally in the form of tablets or capsules. The dosage and frequency depend on the condition being treated, the patient's age, weight, and other factors, and should be determined by a healthcare professional.
4. **Side Effects**: While piroxicam-Ξ²-cyclodextrin may reduce some of the gastrointestinal side effects associated with piroxicam alone, it can still cause adverse reactions such as gastrointestinal irritation, ulcers, bleeding, and renal impairment. Patients should be monitored for these side effects, especially with long-term use or in those with a history of gastrointestinal or renal issues.
5. **Contraindications and Precautions**: Piroxicam-Ξ²-Cyclodextrin should be used with caution in patients with a history of gastrointestinal ulcers or bleeding, renal impairment, heart failure, or hypertension. It is contraindicated in individuals with a known hypersensitivity to piroxicam, NSAIDs, or any component of the formulation. Pregnant women, nursing mothers, and children should also avoid its use unless prescribed by a healthcare professional.
As with any medication, it's crucial to use piroxicam-Ξ²-cyclodextrin under the guidance of a healthcare provider, following their instructions regarding dosage, duration of treatment, and monitoring for potential side effects.
