Dr Mehmood Khan Afridi

Dr Mehmood Khan Afridi Assalam o Alaikom! Islam is the way of life

I have started this page to spread awareness and help people with medical and surgical conditions and it's proper management.All the movers are welcome for any query ,I will gladly help and provide my services.

Irritable bowel syndrome βœ…
24/12/2025

Irritable bowel syndrome βœ…

Points to remember βœ…
24/12/2025

Points to remember βœ…

Pediatrics πŸ’Œ neonatal sepsis/septicemia βœ…
21/12/2025

Pediatrics πŸ’Œ neonatal sepsis/septicemia βœ…

19/12/2025

New Approval for SVT Treatment:
βœ… Etripamil (Cardamyst) β€” FDA-approved in Dec 2025 for acute PSVT episodes in adults (first new SVT drug in decades).

Etripamil belongs to:
Class IV anti-arrhythmic drugs (Calcium Channel Blockers)
β€’ Specifically a non-dihydropyridine calcium channel blocker
β€’ Similar class to verapamil and diltiazem
β€’ Unique feature: ultra-short acting + intranasal, self-administered

Key Distinguishing Points
β€’ βœ”οΈ First self-administered drug for PSVT
β€’ βœ”οΈ Rapid onset, very short half-life
β€’ βœ”οΈ Minimal systemic hypotension compared to IV CCBs
β€’ Not for chronic suppression
β€’ Not for AF, flutter, VT (current indication)

19/12/2025

πŸ’‰πŸ’‰πŸ’‰1069
TRAMADOL (Opioids) worse depression and increase SUICIDAL risk; AVOID in pt with active or recent suicidal thoughts.

Trauma/ massive transfusion protocol  βœ…πŸ’Œ
18/12/2025

Trauma/ massive transfusion protocol βœ…πŸ’Œ

❇️ Abnormalities of the Nail Plate 1. Terry’s Nailsβ†’ Nail plate appears diffusely white or pale with a narrow distal pin...
18/12/2025

❇️ Abnormalities of the Nail Plate

1. Terry’s Nails

β†’ Nail plate appears diffusely white or pale with a narrow distal pink or brown band
β†’ Due to decreased vascularity of nail bed
β†’ Common associations
β†’ Hypoalbuminemia
β†’ Liver cirrhosis
β†’ Congestive heart failure
β†’ Diabetes mellitus
β†’ Chronic kidney disease

2. Salmon Patch (Oil Drop Sign)

β†’ Yellow-pink translucent patch visible beneath nail plate
β†’ Represents psoriatic involvement of nail bed
β†’ Highly specific for nail psoriasis
β†’ Often associated with
β†’ Pitting
β†’ Onycholysis
β†’ Subungual hyperkeratosis

3. Splinter Hemorrhages

β†’ Thin, longitudinal reddish-brown streaks under nail plate
β†’ Caused by rupture of nail bed capillaries
β†’ Seen in
β†’ Trauma (most common)
β†’ Infective endocarditis
β†’ Vasculitis
β†’ Antiphospholipid syndrome

4. Subungual Pigmentation (Low-Grade Hematoma)

β†’ Brownish or reddish discoloration beneath nail plate
β†’ Usually due to minor repeated trauma
β†’ Pigment does not involve nail matrix
β†’ Lesion grows out with nail growth
β†’ Important differential: melanoma

5. Subungual Hematoma

β†’ Dark red, maroon, or black discoloration
β†’ Represents acute bleeding under nail plate
β†’ Usually painful initially
β†’ Common after blunt trauma
β†’ Color migrates distally with nail growth

6. Green Nail Syndrome

β†’ Green-black discoloration of nail plate
β†’ Caused by Pseudomonas aeruginosa infection
β†’ Occurs in moist environments
β†’ Seen in
β†’ Onycholysis
β†’ Chronic water exposure
β†’ Artificial nails

7. Leukonychia

β†’ White spots or transverse white streaks on nail plate
β†’ Due to abnormal keratinization of nail matrix
β†’ Most commonly from minor trauma
β†’ Lesions move distally with nail growth
β†’ Not due to calcium deficiency

8. Blue Nail Discoloration

β†’ Diffuse bluish coloration of nail plate
β†’ Caused by reduced oxygenation or altered hemoglobin
β†’ Seen in
β†’ Cyanosis
β†’ Methemoglobinemia
β†’ Drug-induced (e.g., antimalarials, amiodarone)
β†’ Advanced systemic illness

9. Yellow Nail Syndrome

β†’ Yellow, thickened, slow-growing nails
β†’ Loss of cuticle often seen
β†’ Classic triad
β†’ Yellow nails
β†’ Lymphedema
β†’ Respiratory disease (chronic sinusitis, bronchiectasis, pleural effusion)

10. Longitudinal Melanonychia

β†’ Single or multiple brown-black vertical bands
β†’ Pigment originates from nail matrix melanocytes
β†’ Common causes
β†’ Benign melanocytic activation
β†’ Junctional nevus
β†’ Physiological (especially in darker skin types)
β†’ Requires differentiation from melanoma

11. Subungual Malignant Melanoma (Early)

β†’ Irregular pigmented band with
β†’ Uneven borders
β†’ Color variation
β†’ Widening proximally
β†’ Hutchinson sign may be present
β†’ High suspicion if single digit involved
β†’ Does not move with nail growth

12. Subungual Malignant Melanoma (Advanced)

β†’ Large irregular pigmented mass
β†’ Nail plate destruction or lifting
β†’ Possible ulceration or bleeding
β†’ Represents late presentation
β†’ Poor prognosis if diagnosis delayed

Acute pancreatitis βœ…πŸ©ΊπŸ’Œ
17/12/2025

Acute pancreatitis βœ…πŸ©ΊπŸ’Œ

🧠 Epidural HemorrhageMnemonic: β€œE = Artery & Eye-openingβ€πŸ”§ Mechanism β€’ Arterial bleed (classically middle meningeal arte...
17/12/2025

🧠 Epidural Hemorrhage

Mnemonic: β€œE = Artery & Eye-opening”

πŸ”§ Mechanism
β€’ Arterial bleed (classically middle meningeal artery)
β€’ Blood collects between skull & dura
β€’ Rapid pressure buildup

🧠 Key clues
β€’ Lucid interval β†’ then rapid deterioration
β€’ CT: Lens-shaped (biconvex)
β€’ Trauma / skull fracture

⚑ Emergency surgery needed

🧠 Subdural Hemorrhage

Mnemonic: β€œS = Slow & Senile”

πŸ”§ Mechanism
β€’ Venous bleed from bridging veins
β€’ Blood collects between dura & arachnoid
β€’ Slow accumulation

🧠 Key clues
β€’ Elderly, alcoholics, minor trauma
β€’ CT: Crescent-shaped
β€’ Gradual headache, confusion

🧠 Intraparenchymal Hemorrhage

Mnemonic: β€œP = Pressure burst”

πŸ”§ Mechanism
β€’ Rupture of small vessels inside brain tissue
β€’ Often due to chronic hypertension

🧠 Key clues
β€’ Sudden headache, vomiting, focal deficits
β€’ CT: Round bright bleed in brain
β€’ Think β€œbleeding INTO brain substance”

🧠 Intraventricular Hemorrhage

Mnemonic: β€œV = Ventricles fill”

πŸ”§ Mechanism
β€’ Blood ruptures into ventricles
β€’ Often extension from intraparenchymal or SAH

🧠 Key clues
β€’ Acute headache, vomiting
β€’ CT: Blood inside ventricles
β€’ Risk of hydrocephalus

Septic shock
17/12/2025

Septic shock

Sepsis
16/12/2025

Sepsis

Types of Antibodies (Immunoglobulins)IgGMost common antibody in bloodProtects against bacteria and virusesCan cross the ...
16/12/2025

Types of Antibodies (Immunoglobulins)

IgG

Most common antibody in blood

Protects against bacteria and viruses

Can cross the placenta to protect the baby

IgA

Found in saliva, tears, breast milk, and mucus

Protects body surfaces (gut, lungs)

IgM

First antibody made during an infection

Indicates recent or new infection

IgE

Involved in allergies and asthma

Defends against parasites

IgD

Found in small amounts in blood

Helps regulate immune response

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