07/11/2025
ACE inhibitor (angiotensin-converting enzyme)
Def:
ACE inhibitors are a class of drugs that work by blocking the angiotensin converting enzyme which decrease the production of angiotensin II, a substance that constricts blood vessels. This leads to lower blood pressure and reduced strain on the heart.
Contraindicated:
pregnancy due to potential fetal harm.
Mechanism of Action
ACE inhibitors block the angiotensin-converting enzyme (ACE), which is responsible for converting angiotensin I to angiotensin II.
Angiotensin II causes blood vessels to constrict and stimulates the release of aldosterone, a hormone that causes sodium and water retention, both of which increase blood pressure.
By blocking this conversion, ACE inhibitors cause blood vessels to relax (vasodilation) and reduce the body's sodium and water retention, which lowers blood pressure.
Side Effects
Common: Dry cough, dizziness, headache, fatigue, and low blood pressure (hypotension).
Less Common: Angioedema (swelling of the face, lips, and throat), hyperkalemia (high potassium), and increased blood levels of creatinine.
Drug Class
Class: ACE Inhibitors
At the last of drug mean (suffix pril)
Examples: Captopril, enalapril, and lisinopril Ramipril Fosinopril Benazepril are common examples of this class of drugs.