29/11/2025
Benign yellow dot maculopathy is a rare, non-progressive macular phenotype characterized by bilateral, small yellow dots clustered around the fovea, typically discovered incidentally. Fundus autofluorescence shows corresponding hyperautofluorescent spots, while OCT is usually normal or reveals subtle irregularities at the ellipsoid zone or RPE. Visual acuity and electrophysiological tests are generally preserved. Although many cases are sporadic, familial clustering has been reported, most commonly with an autosomal dominant inheritance pattern, but without identifiable pathogenic variants in known macular dystrophy genes. Long-term follow-up studies confirm the stable and benign nature of this entity, making correct recognition essential to avoid misdiagnosis and unnecessary interventions.
By: .academy
