11/12/2025
ATYPICAL PNEUMONIA (Walking Pneumonia) :
A type of pneumonia caused by organisms that do not show typical lobar consolidation, and symptoms are usually milder, more systemic, and have dry cough.
Common Causes
Bacteria
• Mycoplasma pneumoniae — most common in school-aged children & young adults
• Chlamydophila pneumoniae
• Legionella pneumophila — severe; associated with contaminated water systems
Viruses
• Influenza virus
• RSV
• Adenovirus
• SARS-CoV-2
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Clinical Features
• Low-grade fever
• Dry, persistent cough
• Headache, sore throat
• Fatigue, malaise
• Mild respiratory distress
• Non-specific findings: myalgia, ear pain (bullous myringitis in Mycoplasma)
• GI symptoms (Legionella): diarrhea, vomiting
• Usually no large consolidation on exam
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Physical Exam
• Chest often mildly abnormal despite patient’s significant symptoms
• Diffuse crackles, wheeze
• No focal dullness like typical pneumonia
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Investigations
Chest X-Ray
• Patchy, diffuse interstitial infiltrates
• “Reticulonodular pattern”
• Not matching the physical exam severity
Labs
• CBC: may be normal or mildly raised WBC
• Mycoplasma: cold agglutinins ↑
• Legionella: hyponatremia, ↑ LFTs
• PCR/serology helpful
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Complications
• Mycoplasma:
• Hemolytic anemia, erythema multiforme, neurological symptoms
• Legionella:
• Respiratory failure, multi-organ involvement
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Treatment
First-line
• Macrolides (Azithromycin, Clarithromycin)
Alternatives
• Doxycycline (children >8 yrs)
• Respiratory fluoroquinolones (adults)
Supportive
• Antipyretics
• Adequate hydration
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Prognosis
• Usually excellent
• Symptoms may last weeks even after treatment
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Picture-style Diagram
ATYPICAL PNEUMONIA
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| Causes: Mycoplasma, Chlamydia, |
| Legionella, Viruses |
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| Symptoms: |
| - Dry cough |
| - Low-grade fever |
| - Headache, fatigue |
| - Mild chest signs |
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| X-ray: Patchy interstitial |
| infiltrates |
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| Treatment: Macrolides |
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