Adil Medical Store Formerly Askari Medicines

14/11/2025

11/11/2025

💊 Tramadol: More Risk Than Relief? 🚨

A major review in BMJ Evidence-Based Medicine has shaken beliefs about one of the most commonly prescribed painkillers. Researchers found that tramadol offers little real relief for arthritis, nerve, or back pain — yet doubles the risk of serious side effects including heart disease, chest pain, and even precancerous cell changes.

Once hailed as a “safer opioid,” tramadol’s risks may outweigh its benefits. Experts are now urging doctors to rethink its routine use and tighten prescribing guidelines amid global concerns over opioid misuse and addiction.

28/10/2025

21/10/2025

Your body has a powerful self-cleaning system that activates during hunger or fasting, known as autophagy. In this process, the body breaks down and recycles damaged or aging cells, turning them into usable energy. Think of it as your body’s built-in reset button — keeping cells healthy, strengthening immunity, and slowing the aging process.

Autophagy is vital for maintaining organ health, preventing disease, and promoting overall vitality. Researchers have found that intermittent fasting, calorie restriction, and certain healthy habits can boost this natural repair cycle, allowing the body to heal and renew itself more effectively.

This remarkable process shows that fasting isn’t just about weight control — it supports deep cellular repair, longevity, and resilience. Understanding and activating autophagy could transform our approach to wellness and healthy aging.

The human body is truly a self-repairing system, capable of cleansing, regenerating, and protecting itself in extraordinary ways.

21/10/2025

Researchers have uncovered a key way the protein PCSK9 influences both heart disease and certain cancers by breaking down LDL receptors, which help clear bad cholesterol from the bloodstream. When LDL receptors aren’t working right, cholesterol builds up, raising the risk of heart problems. PCSK9 grabs these receptors and drags them into the cell’s waste system to be destroyed, preventing them from recycling back to clear more cholesterol.

Digging deeper, scientists found that PCSK9 teams up with two other proteins—CAP1 and HLA-C—to form a complex that targets the LDL receptor for destruction. HLA-C, a protein involved in the immune system, acts like a guide, directing this trio to the lysosomes, where the cell breaks down unwanted parts. Interestingly, HLA-C also helps the immune system recognize “self” cells and can boost anti-tumor activity, while PCSK9 helps increase HLA-C levels on the cell surface, potentially protecting against tumor growth.

This discovery shines a light on how PCSK9 not only raises cholesterol levels but also plays a role in cancer and immune response. The hope now is to develop treatments that block PCSK9’s interaction with HLA-C, stopping it from destroying LDL receptors and interfering with immune functions. Such therapies could help manage heart disease and certain cancers more effectively.

Research Paper 📄
PMID: 36566984

11/10/2025

13/09/2025

Breaking Barriers in Thalassemia Care!

05/09/2025

29/08/2025