26/07/2025
کینسر کے علاج میں پیشرفت
A revolutionary mRNA vaccine developed by scientists at the University of Florida could change the way we treat cancer forever. Unlike chemotherapy, radiation, or surgery, this vaccine trains the immune system to recognize and destroy tumors without toxic side effects. It boosts early immune responses known as type-I interferons, which act like biological alarm bells that help the body detect even the most elusive cancer cells. This kickstarts a chain reaction called epitope spreading, allowing the immune system to attack multiple regions of a tumor at once.
What makes this approach so powerful is how it turns cancer’s defenses against itself. The mRNA in the vaccine doesn’t directly kill tumor cells it tells them to produce a protein called PD-L1. This protein acts as a bright flag, alerting the immune system to their presence. In mouse models, the vaccine successfully cleared hard-to-treat tumors and even provided protection against recurrence. The immune response was transferable too meaning it could help fight other tumors as well.
If successful in humans, this could become a universal, off-the-shelf cancer vaccine effective against a wide range of cancers. For patients facing aggressive or treatment-resistant tumors, this opens up a new world of hope. With further research and trials, this innovation may redefine cancer therapy in the next decade.
Source: Qdaisat S. et al., Nature Biomedical Engineering (2025), DOI: 10.1038/s41551-025-01380-1
