25/01/2026
Flunixin Meglumine vs. Meloxicam in Veterinary Practice Anti-inflammatory & Anti-endotoxic NSAIDs - when and why to use each one
Non-steroidal anti-inflammatory drugs (NSAIDs) are cornerstone therapies in veterinary medicine, especially in cases of pain, inflammation, fever, and endotoxemia. Among the most commonly used are Flunixin Meglumine and Meloxicam, each with distinct pharmacological profiles and clinical advantages.
Flunixin Meglumine
A potent non-selective COX inhibitor (COX-1 & COX-2) Widely recognized as a strong anti-endotoxic drug Particularly effective in acute endotoxemia and SIRS caused by Gram-negative bacteria such as E. coli and Salmonella Reduces prostaglandins and thromboxanes released after LPS (endotoxin) exposure, leading to: Decreased fever Reduced cardiovascular and respiratory disturbances Improved clinical comfort
Clinical use
Acute endotoxemia a Severe mastitis, Colic and acute inflammatory conditions limitations because of COX-1 inhibition, prolonged or repeated use may increase the risk of gastrointestinal ulceration and renal compromise. especially in dehydrated animals.
Meloxicam
A preferential COX-2 inhibitor provides effective anti-inflammatory and a**lgesic action with better tissue safety
Preserves COX-1-mediated protective prostaglandins in:
Gastrointestinal tract Kidneys Udder and intestinal tissues
One important advantage is that Meloxicam does not significantly interfere with leukotriene pathways, which play a key role in:
Leukocyte migration into tissues Amplification of immune responses
Clinical use
Conditions requiring longer NSAID use animals at risk of GI or renal damage subacute or controlled inflammatory states practical clinical insight
In severe acute endotoxemia, Flunixin Meglumine is often preferred as the first-line NSAID due to its strong anti-endotoxic effect. In sensitive patients or when prolonged anti-inflammatory therapy is needed, Meloxicam offers a safer alternative. Choosing the right NSAID is not about "which is stronger", but which fits the pathophysiology of the case.
summery
✔ Flunixin Meglumine = powerful anti-endotoxic drug for acute cases
✔ Meloxicam = safer anti-inflammatory option for longer or
sensitive treatments
✔ Rational NSAID selection improves outcomes and reduces complications
Understanding the COX pathway, leukotrienes, and tissue safety is essential for evidence-based veterinary medicine.
