Jagiellonian Centre for Experimental Therapeutics

Jagiellonian Centre for Experimental Therapeutics Jagiellońskie Centrum Rozwoju Leków (JCET), Uniwersytet Jagielloński Those three partners form a comprehensive research infrastructure.

JCET is a unit of the Jagiellonian University, designed to develop experimental pharmacotherapy of lifestyle diseases and endothelium-targeted therapeutics in particular, as well as to develop the collaboration with industry partners in this field. JCET is based on the collaboration of three parties Jagiellonian University (project leader), Lodz University of Technology and Henryk Niewodniczański Institute of Nuclear Physics Polish Academy of Sciences in Kraków. Scientific Teams directly involved in JCET activities originate from four Faculties of the Jagiellonian University (Medicine, Pharmacy, Chemistry aswell as Biochemistry, Biophysics and Biotechnology), from the Institute of Radiation Technology (Faculty of Chemistry of the Lodz University of Technology) and from the Department of Magnetic Resonance Imaging (Institute of Nuclear Physics of Polish Academy of Sciences in Kraków).

Good news! Another paper characterizing endothelial function in patients just published !In this study by J. Nowakowski ...
25/09/2025

Good news! Another paper characterizing endothelial function in patients just published !

In this study by J. Nowakowski et al., we applied three complementary methodologies to assess endothelial function. We demonstrated that compensatory vascular responses may precede overt vascular dysfunction in patients with Rheumatoid arthritis. Monitoring these responses could prove valuable for developing endothelial-guided therapies. https://pubmed.ncbi.nlm.nih.gov/40923245/

The next JCET lecture is about to begin.This time, the lecture will be given by PhD Artur Biela, Professor at the Jagiel...
05/09/2025

The next JCET lecture is about to begin.
This time, the lecture will be given by PhD Artur Biela, Professor at the Jagiellonian University.

See you tomorrow! 😉
01/09/2025

See you tomorrow! 😉

‼ 2nd ROUND ‼ of Admission to the Biomedical Sciences education programme in the Doctoral School of Exact and Natural Sc...
21/08/2025

‼ 2nd ROUND ‼ of Admission to the Biomedical Sciences education programme in the Doctoral School of Exact and Natural Sciences for 2025/26 academic year or 2️⃣ doctoral students 👩‍🔬👨‍🔬in JCET:
1️⃣ Metabolic reprogramming and endothelial dysfunction; towards novel mechanisms linking endothelial function and vascular mitochondrial metabolism (prof. dr hab. Stefan Chłopicki)
➡️ https://science.phd.uj.edu.pl/join/biomedical/topic/-/journal_content/56_INSTANCE_ayWUsfnIfuWH/142594442/158510417?fbclid=IwY2xjawMT5rdleHRuA2FlbQIxMABicmlkETFzUHVLTmFiQXliYTRkMzlMAR6wNParcjzrOeA_fzXlm0HqjPzgInblKjV8_ghiKr6iByl7SqOHHPlI41bk3A_aem_SbJE8iLgfYJU9u8241qFZw
2️⃣ Pharmacology of coronary endothelium in acute decompensated heart failure (prof. dr hab. Stefan Chłopicki & dr hab. Grzegorz Kwiatkowski)
➡️ https://science.phd.uj.edu.pl/join/biomedical/topic/-/journal_content/56_INSTANCE_ayWUsfnIfuWH/142594442/158442449?fbclid=IwY2xjawMT5txleHRuA2FlbQIxMABicmlkETFzUHVLTmFiQXliYTRkMzlMAR4JyH0v6gu_X7Y2c6bVfnRn5hcD0G9ivyXl402jb0vps_DJbaHde9b6Q9eMWg_aem_UVZ75U0v1cnsBrOANE09fA

Nitric oxide (NO) can modulate the oxidation state of cytochrome C… but how does it do it? Interested to find out? Then ...
19/08/2025

Nitric oxide (NO) can modulate the oxidation state of cytochrome C… but how does it do it? Interested to find out? Then we are excited to share our newest research published in Free Radical Biology and Medicine- NO-induced change in the oxidation state of cytochrome c in endothelial cells monitored by resonance Raman imaging by E. Szczesny-Malysiak, A. Bartkowiak, K. Bulat and J. Dybas.
Using Resonance Raman Imaging with a 405 nm laser line specially selected for investigation of cytochrome C oxidation status we were able to investigate the complexity of NO signalling in endothelial physiology. Spectroscopy-derived results were backed up with fluorescence microscopy and flow cytometry measu . See more: https://www.sciencedirect.com/science/article/pii/S0891584925008792?utm_campaign=STMJ_220042_AUTH_SERV_PA&utm_medium=email&utm_acid=302371957&SIS_ID=&dgcid=STMJ_220042_AUTH_SERV_PA&CMX_ID=&utm_in=DM590126&utm_source=AC_

We are happy to share a new publication of JCETeam by Amanda Bartkowiak et al. The study outcome is about heme proteins ...
13/08/2025

We are happy to share a new publication of JCETeam by Amanda Bartkowiak et al. The study outcome is about heme proteins — tiny molecular machines that do some of the most vital jobs in our bodies — from carrying oxygen in our blood to protecting our cells from stress and generating energy.
In our latest study, we took a new approach to this old challenge. Using a technique called polarized resonance Raman spectroscopy — and a specific light wavelength (405 nm) that zeroes in on the heme group — we examined four key players: hemoglobin, cytoglobin, neuroglobin, and cytochrome c.
This method opens up exciting possibilities: it could one day help researchers identify these proteins in complex biological samples, track their changes under disease conditions, or even aid in diagnostics. In short, we’ve found a new way to "see" the hidden differences in some of the body's most essential molecules. See more:
https://www.sciencedirect.com/science/article/pii/S0022286025013353?utm_campaign=STMJ_219742_AUTH_SERV_PA&utm_medium=email&utm_acid=302384013&SIS_ID=&dgcid=STMJ_219742_AUTH_SERV_PA&CMX_ID=&utm_in=DM567183&utm_source=AC_

We are pleased to share our newly published study in Schizophrenia Research, which reveals that patients with first-epis...
11/08/2025

We are pleased to share our newly published study in Schizophrenia Research, which reveals that patients with first-episode psychosis (FEP) exhibit impaired systemic nitric oxide (NO) bioavailability in the absence of typical prothrombotic and proinflammatory plasma biomarkers but with significant functional alterations in the microcirculation of the skin. These findings suggest a distinct endotype of endothelial dysfunction in FEP and offer new insights into the early microvascular effects of psychosis, with potential diagnostic implications. See more: https://pubmed.ncbi.nlm.nih.gov/40774013/

‼ 2nd ROUND ‼ of Admission to the Biomedical Sciences education programme in the Doctoral School of Exact and Natural Sc...
01/08/2025

‼ 2nd ROUND ‼ of Admission to the Biomedical Sciences education programme in the Doctoral School of Exact and Natural Sciences for 2025/26 academic year or 2️⃣ doctoral students 👩‍🔬👨‍🔬in JCET:
1️⃣ Metabolic reprogramming and endothelial dysfunction; towards novel mechanisms linking endothelial function and vascular mitochondrial metabolism (prof. dr hab. Stefan Chłopicki)
➡️ see more: https://science.phd.uj.edu.pl/join/biomedical/topic/-/journal_content/56_INSTANCE_ayWUsfnIfuWH/142594442/158510417
2️⃣ Pharmacology of coronary endothelium in acute decompensated heart failure (prof. dr hab. Stefan Chłopicki & dr hab. Grzegorz Kwiatkowski)
➡️ see more: https://science.phd.uj.edu.pl/join/biomedical/topic/-/journal_content/56_INSTANCE_ayWUsfnIfuWH/142594442/158442449

W dniach 22-24 lipca 2025 miała  miejsce konferencja 6th Central European Biomedical Congress (CEBC), w której wzięli ud...
29/07/2025

W dniach 22-24 lipca 2025 miała miejsce konferencja 6th Central European Biomedical Congress (CEBC), w której wzięli udział członkowie Zespołu JCET: Emilia Seta, Paulina Misiak i Isabelly Annunciato oraz Profesor Stefan Chłopicki, który przewodniczył jednej z sesji.

We are pleased to share our latest findings showing how combining the P2Y12 antagonist cangrelor with energy metabolism ...
08/07/2025

We are pleased to share our latest findings showing how combining the P2Y12 antagonist cangrelor with energy metabolism inhibitors can significantly enhance anti-platelet effects.

This strategy opens new avenues for improving the treatment of cardiovascular diseases by providing a more effective means of preventing thrombosis.

The article by Anna Kurpińska and coauthors titled “Combining the P2Y12 antagonist cangrelor with energy metabolism inhibitors has a synergistic antiaggregatory effect” is available in subscription, however until August 21 - full access via this link: https://authors.elsevier.com/a/1lMhl1RcufcpB

Feel free to read and share your thoughts!

Summer School📆28 August - 3 September 2025A 5-day program on Cardiovascular Safety Pharmacology and Cardio-Oncology cons...
27/06/2025

Summer School
📆28 August - 3 September 2025
A 5-day program on Cardiovascular Safety Pharmacology and Cardio-Oncology consisting of theoretical lectures complemented by hands-on sessions in associated technologies.
⏳ Applay before 30 June‼️
See more: https://www.uantwerpen.be/en/summer-winter-schools/inspire/

Adres

Michała Bobrzyńskiego 14
Kraków
30-392

Godziny Otwarcia

Poniedziałek 08:00 - 16:00
Wtorek 08:00 - 16:00
Środa 08:00 - 16:00
Czwartek 08:00 - 16:00
Piątek 08:00 - 16:00

Telefon

+48126645464

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