Advances in Clinical and Experimental Medicine

Advances in Clinical and Experimental Medicine 5-Year IF 2.0, IF 1.9, JCI (2024) 0.43, Scopus CiteScore 4.3, H-index 49 (SJR)
Initial editorial assessment and first decision within 24 h

📢 Our new manuscript withdrawal policy 📢✔️ Withdrawals initiated by authorsAuthors may withdraw their manuscript at any ...
18/04/2026

📢 Our new manuscript withdrawal policy 📢

✔️ Withdrawals initiated by authors
Authors may withdraw their manuscript at any stage of the editorial process. However, 2 conditions must be met for a withdrawal request to be processed:

– A clear and specific reason for withdrawal must be provided – both in the Editorial System and in the withdrawal statement.
– All authors must consent to the withdrawal. A statement signed by all authors should be scanned and submitted as a PDF file to the editorial office at [redakcja@umw.edu.pl] and/or uploaded to the Editorial System as an Additional File.

Until these conditions are fulfilled, the manuscript cannot be considered withdrawn.

Please note that if you intend to resubmit the manuscript, it is advisable to address necessary corrections during the initial verification or peer-review process rather than withdrawing the submission. A withdrawn and resubmitted manuscript is assessed as an entirely new submission – the previous (withdrawn) submission is not taken into consideration; in consequence, it prolongs the whole assessment process.

✔️ Withdrawals initiated by the editorial office
A manuscript will be withdrawn by the editorial office if:

– After acceptance, evidence for scientific misconduct is found
– Authors fail to sign the license agreement form within 30 days after acceptance
– Authors fail to pay the article processing charge (APC) within 30 days after acceptance
– Authors repeatedly fail to correct the galley proof or cease communication with the editorial office in this regard for more than 30 days.

✔️ Refund policy (withdrawals after the APC has already been paid)
Adv Clin Exp Med does not refund the APC once it has been paid. This policy applies in the following cases:
– When authors withdraw a manuscript after acceptance and payment of the APC (but before publication), regardless of the reason for withdrawal.
– When the manuscript is withdrawn by the editors due to the authors' failure to adequately correct errors or an attempt to change the authorship after acceptance (which violates our policy).
– When articles are retracted after publication due to author error or misconduct.
The APC is not a publication fee but an article-processing charge—it covers the costs of peer review, statistical review, editing, and typesetting. Since the majority of this work is completed before the APC is paid, refunds cannot be issued.
In exceptional cases, authors may appeal to the Editor-in-Chief, whose decision is final.

✔️ Withdrawal after acceptance due to funding limitations
We ask that authors submit papers to our journal only if they have funding. Before submitting, please make sure that you have the necessary funds to pay the APC in case of acceptance.
https://advances.umw.edu.pl/en/article-processing-charges/
Please note that our journal offers neither APC waivers nor discounts, including discounts for researchers from lower-income countries and countries against which international sanctions have been imposed.

✔️ Ethical considerations concerning withdrawals
Before you withdraw a paper, please consider that the editor and reviewers have likely already invested significant time reviewing your manuscript. The further along in the paper's peer-review process, the greater the ethical concern with withdrawing a manuscript, given that a considerable amount of time has been spent on the paper by reviewers, editors, and editorial assistants. Please let us know before withdrawing if there is anything we can do to avoid the withdrawal. We are happy to work with authors to remove any perceived barriers to publishing.
Please note that it is unethical and considered violating scientific norms (i.e., poor scientific practice bordering on scientific misconduct) to submit a paper still under consideration at a journal A to a different journal B. If you have already created a duplicate submission, please withdraw your paper from the other journal immediately and only submit it after receiving confirmation that your withdrawal request has been successfully processed. Otherwise, according to international best practices on publication ethics, a withdrawal may violate the research community's norms and may have negative consequences for the authors.

✔️ Withdrawing a published paper
Withdrawal is possible during the initial verification process, from the peer-review process or after acceptance, before publication. Withdrawing a paper after publication is called a retraction, please see https://advances.umw.edu.pl/en/appeals-complaints-corrections-retractions-commentaries for retraction policies.

🚀Recently published 🚀Updating guidelines for the diagnosis of fetal alcohol spectrum disorders (FASD) in PolandHighlight...
17/04/2026

🚀Recently published 🚀

Updating guidelines for the diagnosis of fetal alcohol spectrum disorders (FASD) in Poland

Highlights

➡️Updated Polish national guidelines standardize fetal alcohol spectrum disorder (FASD) diagnosis, addressing the high prevalence of prenatal alcohol exposure and reducing diagnostic variability.
➡️The introduction of partial fetal alcohol syndrome (pFAS) and the use of biomarkers enhance assessment of prenatal alcohol exposure, improving diagnostic accuracy in the absence of a single definitive test.
➡️Revised criteria simplify the evaluation of facial dysmorphology and clarify central nervous system assessment, improving clinical feasibility and inter-rater consistency.
➡️These evidence-based, consensus-driven FASD guidelines, supported by practical diagnostic tools, may improve global clinical practice by promoting ethical, reliable, and reproducible diagnosis.

https://advances.umw.edu.pl/en/ahead-of-print/217484/

















Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu yczny im. Piastów Śląskich we Wrocławiu

🚀Recently published 🚀Orthobiologics in anterior cruciate ligament (ACL) reconstruction: A narrative review➡️Orthobiologi...
16/04/2026

🚀Recently published 🚀

Orthobiologics in anterior cruciate ligament (ACL) reconstruction: A narrative review

➡️Orthobiologics, including platelet-rich plasma (PRP) and stem cells, are increasingly explored to enhance graft incorporation and ligamentization after ACL reconstruction (ACLR).
➡️Current clinical evidence on PRP and stem cell therapy in ACL repair remains inconsistent, with no clear consensus on efficacy.
➡️Variability in preparation methods, dosing protocols, and study designs limits definitive conclusions on orthobiologics in ACL surgery.
➡️Routine use of orthobiologics in ACLR is not currently recommended, highlighting the need for standardized protocols and high-quality randomized controlled trials.

🔗READ THE ARTICLE: https://advances.umw.edu.pl/en/ahead-of-print/218640/

📚Publish in Advances in Clinical and Experimental Medicine! 📚💪 WHY?– We have a broad scope and publish papers from all f...
16/04/2026

📚Publish in Advances in Clinical and Experimental Medicine! 📚

💪 WHY?
– We have a broad scope and publish papers from all fields of medicine and related sciences;
– Our Impact Factor is 1.9 and steadily rising [see below];
– Our Scopus CiteScore is 4.3 and also steadily rising;
– We publish papers ahead of print [with active DOI] as soon as they are ready – no unnecessary waiting;
– We are indexed in all important databases;
– We offer professional linguistic editing and DTP;
– If you become our reviewer, article processing charge can be waivered.

🔎 HOW?
Create an account here:
https://www.editorialsystem.com/acem/preRegister/?email=
Check our instructions for authors here:
https://advances.umw.edu.pl/en/instructions-for-authors/
and submit your paper!

🔥 EDITORIALS
We invite experts to submit an editorial to our journal. Editorials published in our journal are meant to promote current and crucial directions of research in experimental and clinical medicine. Such article is published free of charge.
https://ojs.umw.edu.pl/files/acem/Flyer_ACEM_popr_2025-editorial%20(9)-1.pdf

🔥 CALLS FOR SUBMISSION
Current calls for submissions in ACEM are listed below. Please share them with the members of your professional networks.
https://advances.umw.edu.pl/en/calls-for-submissions/

📢New call for submissions📢Exploring the Gut-Brain Axis, Implications for Neurological and Psychiatric Disorders – Mechan...
15/04/2026

📢New call for submissions📢

Exploring the Gut-Brain Axis, Implications for Neurological and Psychiatric Disorders – Mechanisms, Biomarkers, and Emerging Therapies

🧠The gut–brain axis represents a rapidly evolving frontier in medicine, shedding new light on how gut microbiota and their metabolites influence brain development, function, and disease. Its importance is increasingly recognized across neuroscience, psychiatry, immunology, endocrinology, and translational medicine.

🧠This special issue of Advances in Clinical and Experimental Medicine seeks to consolidate high-impact, novel research that advances our mechanistic and clinical understanding of gut–brain crosstalk, with a particular focus on its relevance for neurological and psychiatric disorders. We welcome interdisciplinary submissions that go beyond descriptive associations and offer insights into molecular mechanisms, predictive biomarkers, sex-specific effects, response to therapy, and new avenues for clinical intervention.

🧠Suggested thematic areas

➡️Microbiota and neurodevelopment: Mechanistic and clinical studies on how gut microbes influence brain development, connectivity, and vulnerability to disorders like ASD and ADHD.

➡️Gut dysbiosis in psychiatric disorders: Novel links between altered microbial composition and psychiatric conditions such as depression, anxiety, schizophrenia, and bipolar disorder.

➡️Molecular communication pathways: Exploration of immune, endocrine, vagal, and epigenetic mechanisms mediating gut–brain signaling beyond known metabolic routes.

➡️Sex-specific differences in the gut–brain axis: Studies focusing on gender-related variations in microbiota composition, signaling, and effects on neuropsychiatric trajectories.

➡️Microbiota–drug interactions: How gut microbes influence drug metabolism, therapeutic response, and treatment tolerability in psychiatric patients.

➡️AI and computational modeling: Predictive modeling of brain disorders or treatment outcomes based on microbiome and host data using artificial intelligence.

➡️COVID-19 and post-viral neuropsychiatric sequelae: Investigations into the role of gut dysbiosis in persistent cognitive and mood symptoms following COVID-19 and similar infections.

➡️Microbiome-based therapies: Evaluation of targeted interventions - such as psychobiotics, prebiotics, dietary patterns, and FMT – in mental health care.

➡️Metabolomic profiling: Identification of gut-derived bioactive compounds that modulate brain function via neurotransmitter or hormonal pathways.

➡️Gut barrier integrity and neuroinflammation: Role of increased intestinal permeability and systemic inflammation in dementia, mood disorders, and neurodegeneration.

➡️Translational and clinical studies: Implementation research, including clinical trials, safety data, treatment biomarkers, and regulatory perspectives.

🔗MORE INFORMATION: https://advances.umw.edu.pl/en/gut-brain-axis

🚀Recently published 🚀Heart failure in Poland: Epidemiology, hospitalizations, and trends from 2014 to 2021Highlights➡️Ov...
14/04/2026

🚀Recently published 🚀

Heart failure in Poland: Epidemiology, hospitalizations, and trends from 2014 to 2021

Highlights

➡️Over 1 million heart failure (HF) patients were registered in Poland by 2019, with a standardized prevalence rate of 2,626 per 100,000 in 2021.
➡️The highest HF burden was observed in the 80–89 age group, comprising 32% of all diagnosed cases.
➡️Despite declining hospitalizations, healthcare utilization remained high with 9.2 million HF-related services recorded between 2014 and 2021.
➡️The study reveals an 18–25% gap between HF hospitalizations and outpatient treatment, underscoring significant care-coordination challenges.

🔗Read the article here: https://advances.umw.edu.pl/en/ahead-of-print/208786/


🚀Recently published 🚀Internal peacekeepers and external mediators: A new model of peripheral immune tolerance involving ...
13/04/2026

🚀Recently published 🚀

Internal peacekeepers and external mediators: A new model of peripheral immune tolerance involving regulatory T cells and mesenchymal stem cells

Highlights

➡️This editorial expands on the 2025 Nobel Prize-recognized role of regulatory T cells by introducing mesenchymal stem/stromal cells (MSCs) as critical “external checkpoints” in immune regulation.
➡️Tissue-resident MSCs respond to inflammation by secreting immunosuppressive mediators, promoting tissue repair, and locally dampening excessive immune responses, complementing Treg-mediated immune control.
➡️The integrated Treg–MSC tolerance model provides new insights into autoimmune disease mechanisms and tumor immune evasion, and highlights the therapeutic potential of MSC-based immunomodulatory strategies.

🔗Read the article here: https://advances.umw.edu.pl/en/ahead-of-print/216728/


📰New category in our journal – Study Protocol articles 📰✅ Study Protocol articles provide a comprehensive overview of th...
11/04/2026

📰New category in our journal – Study Protocol articles 📰

✅ Study Protocol articles provide a comprehensive overview of the design of prospective research, aiming to facilitate the dissemination of ongoing studies and enhance transparency in clinical and biomedical research. These articles outline the hypothesis, rationale, methodology, and ethical considerations of the study, serving as a valuable resource for researchers and clinicians.

✅ We consider study protocols for proposed or ongoing prospective clinical research, provided that participant recruitment has not been completed at the time of submission. Protocols for retrospective studies, feasibility studies, or pilot studies are not eligible. Additionally, study protocols will not be considered if any articles reporting data from the study have already been published or are under review.

📌 Submission Guidelines 📌

• Study Protocol articles undergo peer review.
• The manuscript should not exceed 3,500 words.
• A maximum of 10 figures and/or tables may be included.
• The paper should follow a 5-part structure: Highlights, Introduction, Methodology, Discussion, Conclusion.
• The abstract should not exceed 300 words and follow a 4-part structure: Introduction, Methodology, Discussion, Conclusion.
• Formal ethical approval of an appropriate ethics committee is mandatory.
• For clinical studies, registration in a public clinical trial registry is mandatory prior to manuscript submission.
• Authors are strongly encouraged to follow the SPIRIT guidelines (SPIRIT Statement).

This structured approach ensures that Study Protocol articles contribute meaningfully to the research community while maintaining rigorous academic and ethical standards.

https://advances.umw.edu.pl/en/instructions-for-authors/

📢New call for submissions📢Call for Submissions of an Expression of Interest for an Adv Clin Exp Med Special Collection o...
10/04/2026

📢New call for submissions📢

Call for Submissions of an Expression of Interest for an Adv Clin Exp Med Special Collection on Advances in Hand Surgery and Hand Therapy

The hand is a remarkably complex organ, and even minor injury or disease can severely impair its function, making precise assessment essential for accurate diagnosis, effective treatment, and successful rehabilitation.

🧠Hand surgery combines orthopedics, plastic and reconstructive surgery, microsurgery, and traumatology. Advances in techniques, biomaterials, and regenerative medicine continue to improve outcomes and quality of life. Hand therapy – encompassing physiotherapy, occupational therapy, splinting, pain management, and patient education – plays an equally vital role in restoring fine motor skills after delicate surgical repair.

🧠Effective management of hand conditions depends on close interdisciplinary collaboration among surgeons, therapists, and other professionals. Despite progress, challenges remain in achieving long-term functional recovery, improving patient-reported outcomes, and ensuring equitable access to care. Evidence-based healthcare (EBHC) provides the foundation for modern practice, integrating clinical expertise, research evidence, and patient values.

🧠Articles submitted should address the broad field of hand surgery and hand therapy. Contributions may focus on fundamental principles of hand function, such as anatomy and biomechanics, clinical examination, functional assessment, imaging, electrodiagnostic studies, and patient-reported outcome measures, as well as modern diagnostic approaches, surgical techniques, therapeutic strategies, and interdisciplinary care.

Suggested topics include, but are not limited to, hand surgery and hand therapy in the following conditions:

➡️Traumatic injuries: fractures, dislocations, flexor and extensor tendon injuries, nerve and vascular injuries, amputations and replantations, and complex post-traumatic reconstructions.

➡️Degenerative and inflammatory diseases: osteoarthritis, rheumatoid arthritis, scleroderma, and other connective tissue diseases.

➡️Neurological conditions: stroke, tetraplegia, peripheral and central neurologic diseases, and nerve compression syndromes.

➡️Congenital and developmental disorders: congenital anomalies and deformities in children, including malformations requiring surgical correction and long-term therapy.

➡️Metabolic and systemic disorders: diabetes-related hand conditions and other systemic metabolic diseases affecting the hand.

➡️Burns of the hand: acute surgical treatment, reconstructive procedures, and long-term rehabilitation, including scar management, splinting, and functional recovery.

➡️Tumors of the hand and wrist: benign and malignant tumors.
Infections: acute and chronic infections.

➡️Vascular disorders: Raynaud’s phenomenon, ischemic conditions, and vascular insufficiency of the hand.

➡️Iatrogenic and secondary conditions: complications after surgery, contractures, scarring, stiffness, and chronic pain syndromes.

➡️Other common hand problems: Dupuytren’s contracture, trigger finger, ganglion cysts, and other frequently encountered conditions

🔗MORE INFORMATION
https://advances.umw.edu.pl/en/hand-surgery-therapy



Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

🚀Recently published🚀Comparative prognostic evaluation of SOFA and PSS scores in pediatric septic shock: A retrospective ...
09/04/2026

🚀Recently published🚀

Comparative prognostic evaluation of SOFA and PSS scores in pediatric septic shock: A retrospective study

Highlights

➡️SOFA and Phoenix Sepsis Score (PSS) predict pediatric septic shock mortality effectively, with SOFA showing a slightly stronger overall correlation.
➡️PSS offers higher sensitivity in infants and younger children, while SOFA provides greater accuracy in older pediatric patients.
➡️Neurological and respiratory dysfunction drive mortality risk in both scoring systems, underscoring their prognostic importance.
➡️SOFA outperforms PSS in respiratory and postoperative cases, whereas PSS is more accurate in neurological and gastrointestinal disease contexts.
➡️Combining SOFA and PSS may optimize clinical decision-making, improving risk stratification and management in pediatric septic shock.

🔗READ THE ARTICLE: https://advances.umw.edu.pl/en/ahead-of-print/204830/








🚀Recently published🚀Hypophosphatasia in children: From low alkaline phosphatase activity to diagnosis, genetic testing, ...
08/04/2026

🚀Recently published🚀

Hypophosphatasia in children: From low alkaline phosphatase activity to diagnosis, genetic testing, and treatment options. A narrative review

Highlights

➡️Clinical heterogeneity of hypophosphatasia (HPP) was demonstrated among pediatric patients.
➡️Alkaline phosphatase (ALP) activity measurement is essential for all children with suspected HPP.
➡️Early and accurate diagnosis of HPP is crucial since enzyme replacement therapy is now available.

https://advances.umw.edu.pl/en/ahead-of-print/205341/

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu
Robert Stanisław Śmigiel















📢Out in Health: Health Equity and Innovations in LGBT+ Care📢Call for submissions of an Expression of Interest for an Adv...
07/04/2026

📢Out in Health: Health Equity and Innovations in LGBT+ Care📢

Call for submissions of an Expression of Interest for an Adv Clin Exp Med Special Collection on LGBT+ Health Equity and Innovation

This Call for Submissions invites Expressions of Interest for a Special Collection of Advances in Clinical and Experimental Medicine, focusing on LGBT+ health equity and innovation.

🧠LGBT+ individuals around the world face unique and persistent health disparities driven by stigma, discrimination, and systemic exclusion from healthcare systems. These inequities result in significantly worse physical and mental health outcomes and limit access to inclusive, culturally competent care.

🧠This Special Collection will offer researchers and clinicians an opportunity to publish original research, meta-analyses, and review articles that address these disparities and propose inclusive, personalized, and innovative solutions to improve health outcomes for LGBT+ populations.

This Call welcomes submissions on (but not limited to):

* Mental Health & Well-being
* Sexual & Reproductive Health
* Transgender & Gender-Diverse Health
* Equity in Healthcare Access
* Social Determinants of Health
* Stigma & Healthcare Avoidance
* Community & Public Health Initiatives
* Intersectionality in Health

🔗MORE INFORMATION
https://advances.umw.edu.pl/en/lgbt




Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu
Dr hab. Michał Czapla

Adres

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