Academia do Cérebro - Évora

30/11/2025

Supercomputer Builds Most Detailed Mouse Cortex Simulation

A massive new brain simulation powered by one of the world’s fastest supercomputers recreates an entire mouse cortex with nearly ten million neurons and billions of synapses.

This biophysically realistic model lets scientists test how diseases spread, how brain waves guide focus, or how seizures evolve — all in a virtual environment.

Built using data from the Allen Institute and run on the supercomputer Fugaku, the project marks a major leap toward whole-brain simulations.

Researchers say the achievement shows that full-scale, biologically detailed models of entire brains — even human ones — are now within reach.

01/11/2025

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19/10/2025

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17/10/2025

Abuso infantil deixa cicatrizes biológicas duradouras no cérebro.

Child Abuse Leaves Lasting Biological Scars on the Brain and DNA

Childhood abuse and neglect can leave a measurable imprint on DNA, affecting how the brain develops.

Using genome-wide analysis, researchers uncovered specific methylation sites, including FOXP1, which was strongly linked to structural brain changes.

These alterations occurred in regions responsible for emotion, memory, and social processing.

The findings offer new biological evidence of trauma’s enduring effects and could lead to early screening and intervention strategies.

09/10/2025

Sugar Chains in the Brain: New Pathway Behind Depression Found

A new study shows that abnormal sugar modifications on brain proteins can directly cause depressive symptoms, shifting the focus away from traditional neurotransmitter-based explanations.

Chronic stress alters glycosylation in the prefrontal cortex, destabilizing brain circuits and impairing emotional regulation.

By targeting the enzyme St3gal1, researchers were able to either trigger or relieve depressive-like behaviors in mice, identifying it as a central molecular switch.

This discovery opens promising new pathways for treating depression beyond current drug options.

05/10/2025

05/10/2025

https://www.linkedin.com/posts/alexandremr_o-maestro-invis%C3%ADvel-que-comanda-seu-corpo-ugcPost-7378495523604824064-w7uS?utm_source=social_share_send&utm_medium=member_desktop_web&rcm=ACoAABneyZQBckXPV7ysDjItLdpBk4fshSEFQRE

O Maestro Invisível que Comanda Seu Corpo Você já se perguntou quem orquestra cada movimento, pensamento e emoção em seu dia a dia? Essa função é do sistema nervoso, a rede mais complexa do corpo humano, capaz de transformar simples estímulos em ações sofisticadas. O sistema nervoso centr...

12/09/2025