25/04/2026
Systemic inflammation mediating the relationship between lifestyle factors and musculoskeletal pain: a systematic review
Front. Pain Res., 01 April 2026
Sec. Musculoskeletal Pain
Volume 7 - 2026 | https://doi.org/10.3389/fpain.2026.1755744
"Systemic inflammation may represent a biological pathway linking sleep disturbances and obesity to musculoskeletal pain, likely operating alongside other mediating factors. For psychological factors, systemic inflammation appears to act as an interacting variable rather than a direct mediator of pain. Given the reliance on cross-sectional data in current research, longitudinal studies are essential to confirm these causal mechanisms and to evaluate the clinical significance of targeting systemic inflammation in pain management."
Sursa:
https://www.frontiersin.org/journals/pain-research/articles/10.3389/fpain.2026.1755744/full?fbclid=IwVERTSARZW99leHRuA2FlbQIxMABzcnRjBmFwcF9pZAwzNTA2ODU1MzE3MjgAAR6hx2mmFfF72GnnL0WxzSwoU5AXE6XSgy2sFFXwo5Ea2UebFLgcZsLhD5_QAQ_aem_jPVGgHyosiqWyXp-Orgbzw
BackgroundA range of studies have shown that psychological and lifestyle factors are associated with musculoskeletal pain. The factors also correlate with pe...