The Endocrine Club

The Endocrine Club General endocrinology and diabetes practical points
Chairman/admin :
Abdulqawi Almansari MBBS FACP FACE

Chairman Abdulqawi Almansari MD FACP FACE
Consultant endocrinologist
Myclinic alsafa Jeddah
American board of Endocrinology Diabetes and Metabolism2000
American Board internal Medicine 1998

14/03/2026

Why Medullary thyroid cancer was seen in rodents early study but NOT IN HUMAN ?

GLP-1Rs and thyroid C cells. GLP-1Rs are typically expressed in rodent C cells , but there are almost no GLP-1Rs are in healthy human

J Clin Invest. 2026;136(4):e194740

14/03/2026

For women with gestational diabetes who have a fasting plasma glucose level below 7 mmol/litre at diagnosis, offer a trial of diet and exercise changes.

NICE 2020

14/03/2026

Iatrogenic hypoglycemia may occur after sudden reduction of corticosteroid dose
ADA 2026

14/03/2026

Before starting an SGLT-2 inhibitor, check whether the person may be at increased risk of diabetic ketoacidosis (DKA), for example if they:
Previous episode of DKA
Intercurrent illness
At risk of dehydration or volume depletion
Following a very low carbohydrate or ketogenic diet.

NICE 2026

14/03/2026

Hyperkalemia associated with the use
of an ACEi or ARB can often be managed by measures to
reduce serum potassium levels rather than decreasing the
dose or stopping the ACEi or ARB immediately

KDIGO2022

14/03/2026

Weight loss may improve fertility
NICE 2026

13/03/2026

Consider radioactive iodine or surgery for Graves’
with persistent or relapsed
NICE 2023

13/03/2026

S. PTH provide critical information in patients with hypocalcemia and should be measured with S calcium simultaneously
PTH is low with hypoparathyroidism and hypomagnesemia
PTH is elevated in kidney disease, vitamin D deficiency

U2D

13/03/2026

Consider Metformin to prevent hyperglycemia in high risk individuals treated with high dose glucocorticoids

ADA 2026

13/03/2026

For women with gestational diabetes who have a fasting plasma glucose level of between 6.0 and 6.9 mmol/litre and complications such as macrosomia or hydramnios, consider immediate treatment with insulin, with or without metformin

NICE 2020

13/03/2026

S. calcium to fall by 0.8 mg/dL for every 1 g/dL fall in S. albumin
If t calcium is 8 mg/dL and albumin is 2 g/dL the corrected value will be 9.6 mg/dL which is normal.

U2D

13/03/2026

We recommend treating
patients with type 2 diabetes (T2D), CKD, and an
eGFR > 20 ml/min per 1.73 m2 with an SGLT2i (1A).

KDIGO 2022

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