The Endocrine Club

13/01/2026

The absence of five classic risk factors (Obesity, Smoking, HT, DM, and DL) at 50 years of age was associated with more than a decade greater life expectancy.

NEJM 10/7/2025

13/01/2026

In one study, the risk of developing DM2 was also increased for nonsmokers who had been exposed to second hand smoke
Uptodate

13/01/2026

Maintain serum 25-hydroxyvitamin D ≥30 ng/mL in patients with osteoporosis (preferable range 30 to 50 ng/mL) (Grade A)
AACE 2020 Osteoporosis guidelines

12/01/2026

In sexually active individuals of childbearing potential who are not using reliable contraception, avoid ACE inhibitors, ARBs, MRAs, direct renin inhibitors, and neprilysin inhibitors, as they are contraindicated in pregnancy. A

ADA 2026

12/01/2026

Based on the ALLHAT study, The doxazosin arm of the study was terminated early because it was found to have a significantly higher rate of combined cardiovascular events, primarily driven by a doubled risk of heart failure compared to the chlorthalidone group.

12/01/2026

What is the antihypertensive option in this case..
35 year M with Graves disease, BP repeatedly > 140/90 . Pulse 108/m regular

12/01/2026

Among patients with type 2 diabetes, the incidence of major cardiovascular events was significantly lower with intensive treatment targeting a systolic blood pressure of less than 120 mm Hg than with standard treatment targeting a systolic blood pressure of less than 140 mm Hg.

N Engl J Med 2025;392:1155-1167

12/01/2026

In summary
Aspirin should not be used routinely in primary prevention ( people with no previous CVD)

11/01/2026

CKD risk models

The KDIGO 2024 Clinical Practice Guideline for Chronic Kidney Disease recommends estimating GFR using equations that combine both creatinine and cystatin C, such as CKD-EPI and EKFC, for more accurate assessment than either marker alone.

For patients with advanced CKD, clinicians should also use validated risk models to better predict the likelihood of progression to kidney failure.

https://ja.ma/3ZbdOvq

11/01/2026

Adding Ezetimibe to a Lower Statin Dose may be Better Tolerated with Forceful Reduction of LDL-c/Non-HDL-c than increasing statin

NICE 2022

11/01/2026

If Initial BP is over 159/90 . start 2 blood pressure agent .
Single pill combination is preferred for better adherence.

Modified from ADA 2026

11/01/2026

Consider combination therapy in adults with type 2 diabetes for initial treatment to shorten time to attainment of individualized glycemic goals. A

ADA 2026