20/10/2025
"I wish I had taken part sooner."
Gulliver was diagnosed with clinical depression at 19. For years, he struggled with extremely low mood, anxiety, frequent panic attacks and occasional paranoia.
💊 He tried a range of treatments, including antidepressants and talking therapies. But nothing helped with his symptoms.
📱 Then his mother came across a clinical trial called PAX-D on Facebook. As a therapist, she would receive a lot of information about mental health studies and thought the trial could help her son.
The study was testing whether a drug commonly used for Parkinson’s disease could help with treatment-resistant depression. Unlike antidepressants, which target serotonin, pramipexole mimics dopamine, which influences the energy with which people pursue goals.
He continued to take pramipexole after the trial concluded. A year ago, he stopped taking the drug, or any other antidepressants. It is the longest he has been off medication since he was 19.
💬 He said: “The day after I started taking the drug I felt so much better. I had loads more energy and stopped sleeping during the day. My sleep quality improved drastically as well as my overall mood.”
Read Gulliver’s story in The Guardian below ⬇️
Exclusive: Gulliver Waite signed up after antidepressants and talking therapies failed to alleviate clinical depression