23/04/2026
New AMRA Research Assessing the Impact of AMC in CKD Published in Clinical Journal of the American Society of Nephrology!
AMRA Medical researchers recently set out to answer the question: does muscle composition identify high-risk individuals with chronic kidney disease? The answer showed that adverse muscle composition (AMC), characterized by low muscle volume z-score and high muscle fat infiltration, is an independent and strong predictor of all-cause mortality in individuals with chronic kidney disease (CKD).
Over a mean follow-up period of 3.6 years, individuals with CKD and AMC showed a markedly increased risk of all-cause mortality, with an unadjusted hazard ratio of 6.17. Importantly, this association remained significant even after adjusting for demographic, lifestyle, and clinical factors, with a hazard ratio of 4.21.
These findings highlight AMC as a clinically meaningful phenotype, enabling broader stratification of high-risk individuals and supporting the value of MRI-based muscle biomarkers in clinical trials across chronic diseases.
Read the full release from AMRA: https://amramedical.com/does-muscle-composition-identify-high-risk-individuals-in-chronic-kidney-disease-new-amra-medical-study-says-yes-reveals-strong-link-to-mortality/