11/02/2026
๐ฌ New Research Findings: ๐๐จ๐ฆ๐จ๐ ๐ซ๐๐ฆ-๐๐๐ฌ๐๐ ๐๐ง๐๐ฅ๐ฒ๐ฌ๐ข๐ฌ ๐จ๐ ๐ฉ๐ฅ๐๐ฌ๐ฆ๐ ๐๐ฅ๐๐ฎ๐ฆ๐ข๐ง ๐๐ง๐ ๐-๐ซ๐๐๐๐ญ๐ข๐ฏ๐ ๐ฉ๐ซ๐จ๐ญ๐๐ข๐ง 30 ๐๐๐ฒ๐ฌ ๐๐๐๐จ๐ซ๐ ๐๐ฅ๐จ๐จ๐๐ฌ๐ญ๐ซ๐๐๐ฆ ๐ข๐ง๐๐๐๐ญ๐ข๐จ๐ง ๐๐จ๐ซ 30-๐๐๐ฒ ๐ฆ๐จ๐ซ๐ญ๐๐ฅ๐ข๐ญ๐ฒ ๐ข๐ง ๐๐ข๐ง๐ ๐๐ฉ๐จ๐ซ๐ ๐๐ง๐ ๐๐๐ง๐ฆ๐๐ซ๐ค
Nomogram models of plasma albumin (PA) and C-reactive protein (CRP), in patient cohorts from Singapore and Denmark with bloodstream infection (BSI), showed that PA level in the pre-infection and infection periods is a strong prognosticator of 30-day mortality risk.
๐๐๐ฒ ๐๐ข๐ง๐๐ข๐ง๐ ๐ฌ:
โข PA levels showed consistent positive correlations with D0 (day of BSI) across all earlier time points, indicating that albumin is a stable prognostic biomarker in the pre-infection period.
โข PA levels measured on D0 and days prior to D0, showed strong associations with 30-day mortality risk, while CRP levels did not show significant associations.
โข Nomogram models demonstrated that the earliest PA level was the most significant contributing factor to mortality risk, while other variables including CRP were not associated with 30-day mortality risk.
๐๐ญ๐ฎ๐๐ฒ ๐ข๐ฆ๐ฉ๐ฅ๐ข๐๐๐ญ๐ข๐จ๐ง๐ฌ:
Strong associations between PA levels and mortality risk throughout multiple time points, especially during the pre-infection period, potentially allows for early warning for negative outcomes. Nomogram-based analysis also provides a distinguishable graphical representation for clinicians to assess patientsโ prognosis and detect a suspected BSI early.
๐๐๐๐ ๐ฆ๐จ๐ซ๐ ๐ก๐๐ซ๐: https://doi.org/10.1038/s41598-025-34710-z
This study aimed to assess the prognostic impact of plasma albumin (PA) and C-reactive protein (CRP), measured up to 30 days before a bloodstream infection (BSI), on 30-day mortality risk using nomogram models. Two cohorts comprising 5,221 inpatients from Singapore (SG) and 15,710 from Denmark (DK)....