National Neuroscience Institute

23/02/2026

Unlocking the world of Parkinson’s disease that’s hidden from the human eye, using !

For Assistant Professor Chao Yinxia, Junior Principal Investigator at NNI and Dr Jackwee Lim of Agency for Science, Technology and Research (A*STAR), Google’s AI system has opened new doors to discovery in structural biology.

With AlphaFold’s AI-based structure modelling capabilities, the researchers can view a complete model of the STIP1 protein and understand how it functions in the human body – providing new insights into future strategies to help with early detection, diagnosis and potentially even a cure for Parkinson’s Disease.

Discover how AI is supporting Parkinson’s Disease research at NNI in this video, featuring Dr Chao and Dr Lim: https://youtu.be/RNysX62I3pw?si=7W-GXmMA_kLtSBRQ

Dr. Jackwee Lim, Senior Scientist at A*STAR is pioneering a breakthrough in the fight against Parkinson’s Disease. By mapping the 3D structure of STIP1 prote...

20/02/2026

This National Caregivers Day, we celebrate those who dedicate their hearts and hands to caring for others 🤲🏼

💖 To all caregivers - your compassion, resilience, and selfless service makes an extraordinary difference every day, but don’t forget to take care of yourself too! We’ve gathered some wellbeing advice just for you.

For more information on support groups, visit: https://www.nni.com.sg/community-care/patient-support-groups
For more information on the Memory Care function, visit: https://www.nni.com.sg/health-information/health-apps/memory-care

19/02/2026

Walking is a simple yet effective way to keep both your body and brain active! So why not have fun while also keeping your brain healthy? 🧠

Join SingHealth Community Hospitals iWalk 2026 on 11 April (Saturday) and enjoy a healthy weekend walk, followed by live performances, interactive games and a whole lot of fun! 😄

Register at www.iwalk.sg for a great day out!

13/02/2026

🔴🚦 Red light! Give a brain health fact about running or walking and don’t get caught by the Robot Doctor! 🤔🦑

Watch this video to learn more about the benefits of running and walking for your brain, and if you’re stuck, take 5 steps back as a reminder that when we stop moving, our brain health can take a few steps back too! 🏃‍♀️🚶🧠

13/02/2026

This is no rookie mistake – one of NNI’s clinical research coordinators (CRCs), Cherlyn Joyce Lee Xuan Yi, took home the Rookie of the Year Award at the SingHealth CRC Day’s Impact Awards on Wednesday!

CRC Day 2026 gathered clinical research coordinators from across SingHealth institutions to celebrate the work of CRCs and recognise those who have positively influenced their peers through the Impact Awards. The Rookie of the Year Award commends outstanding junior CRCs with under two years of service.

As part of the NNI team that recruits participants for Parkinson’s Disease research studies under Prof Tan Eng King, Cherlyn’s insights on research workflows, proactive contributions and work efficiency have helped her team’s efforts in recruiting more than 300 research participants last year, benefitting the studies significantly.

Congratulations, Cherlyn!

12/02/2026

Congratulations to Dr Nicole Keong and Assoc Prof Deidre De Silva for being recognised at last week’s Centre for Clinician-Scientist Development (CCSD) & Dean’s Celebration Dinner by Duke-NUS Medical School! 🎉

Dr Nicole Keong received the Clinician Researcher Advancement Funding Talent Scheme (CRAFTS) Award, which supports outstanding and talented clinician researchers who are on the research track at SingHealth/Duke-NUS Academic Medical Centre. Dr Keong’s team has developed a new way of classifying brain tissue using diffusion tensor imaging (DTI) to create distinct tissue signatures that can forecast a patient’s clinical journey ahead of time. With this, they hope to help more patients achieve their fullest recovery potential.

As a member of CCSD faculty, Assoc Prof Deidre De Silva was appreciated for her invaluable contributions to their programmes. Her generosity in sharing knowledge and her commitment to advancing the field continue to inspire the communities we serve.

Congratulations once again, and we are grateful for the impact they continue to make! ❤️

12/02/2026

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson’s disease, the second most common human neurodegenerative disease. Although the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson’s disease is still unclear, the advancement of stem cell approaches has shown promise for Parkinson’s disease research and therapy.

Researchers from National Neuroscience Institute and Duke-NUS Medical School discussed the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem cells.

They concluded that the discovery of current stem cell techniques for deriving induced pluripotent stem cells (iPSCs) from differentiated cells and further differentiation into distinct lineages of cells has opened new avenues of research, including in the field of neurobiology.

Read more in Neural Regeneration Research, Wolters Kluwer: https://bit.ly/46LlKZ6

AMC researchers involved: Ling-Xiao Yi, Genevieve Saw, Li Zeng, Eng King Tan, Zhi D**g Zhou



Visit Academic Medicine Research Institute - AMRI at https://www.singhealthdukenus.com.sg/research

11/02/2026

Spreading lunar new year joy, one orange at a time 🍊 Our leadership started their morning with the annual Orange Giving around NNI offices and clinics at Tan Tock Seng Hospital (TTSH) and Singapore General Hospital today!

Specially-designed NNI Fund-themed red packets and stickers were also gifted to staff and patients to wish them good health and prosperity in the new lunar year🧧 Here at NNI, we look forward to ringing in another year of breakthroughs and quality care for patients!

06/02/2026

Success is built on the dedication and commitment of people. ❤️

As we commemorate the opening of the NNI Neuroscience Clinic (SGH) and the new Neuro-Diagnostic and Therapeutic Centre (NDTC), we’re also celebrating the incredible team of Singapore General Hospital and NNI staff behind it.

Thank you to every person who has worked hard to make this possible, both behind the scenes and on the ground! And a special thank you to Assoc Prof Ruban Poopalalingam, Group Chairman Medical Board, SingHealth, and Tan Jack Thian, Group Chief Operating Officer, SingHealth & Chief Operating Officer, Singapore General Hospital, for joining us at our staff celebration and marking this milestone with us.

06/02/2026

A flower bouquet for your loved one, and a gift of support for patients with neurological conditions 💐

At the SingHealth Cluster Charity Bazaar on Wednesday, colleagues from across SingHealth institutions took home ready-made bouquets – some even tried their hand at crafting their own bouquets! Just as these forever flowers will stay with their recipients for a long time, each donation for the bouquets leaves a lasting impact on the patients that the NNI Fund supports.

A little goes a long way – contributions to the NNI Fund helps our neuroscience research, education and patient care programmes to continue blooming, offering hope and transforming the lives of patients with neurological conditions.

Want to make a gift? Visit the NNI Fund page for more information.

04/02/2026

Marco? Polo! 💦

Every splash strengthens your body and boosts your brain, so just keep swimming! 🏊‍♂️

And for more ways to protect your brain, head over to our Brain Health story highlights! 🧠✨

02/02/2026

Have an upcoming appointment with NNI at Tan Tock Seng Hospital (TTSH) 🏥?

Follow the three-step process to breeze through your appointment.

Go Digital! Go Mobile! Download the NHG Health App and make your visit to NNI@TTSH stress-free with this guide: for.sg/visit-nni-ttsh