Academic Medicine Research Institute - AMRI

Academic Medicine Research Institute - AMRI ​The Academic Medicine Research Institute (AMRI) is a one-stop research enabler that provides admi

Season’s greetings from all of us at AMRI! May your days be merry and bright as we celebrate the joy of the season! This...
25/12/2025

Season’s greetings from all of us at AMRI! May your days be merry and bright as we celebrate the joy of the season!

This year, let’s also take a moment to reflect on the incredible advancements in that continue to enhance our lives.

As we look forward to the new year, may we all be inspired to contribute to a brighter, healthier future for our communities and the world!



Visit Academic Medicine Research Institute - AMRI at https://www.singhealthdukenus.com.sg/research

  🎉 This year, our researchers from SingHealth Duke-NUS AMC have achieved remarkable milestones globally, from being nam...
24/12/2025

🎉 This year, our researchers from SingHealth Duke-NUS AMC have achieved remarkable milestones globally, from being named Clarivate Highly Cited Researchers, to earning recognition in prestigious lists such as Top Ophthalmologists.

👏 Their achievements and contributions continue to inspire those who are still working towards advancing healthcare and improving lives. Our AMC will certainly be pushing the boundaries of research even further in 2026! ✨

View the full list of SingHealth Duke-NUS AMC awardees via the links below.

Clarivate Highly Cited Researchers 2025: https://for.sg/clarivate-highly-cited-researchers-2025
World Top 2% Most Cited Scientists 2025: https://for.sg/world-top-2-percent-most-cited-scientists-2025
Best Medicine Scientist in Singapore 2025: https://for.sg/best-medicine-scientists-in-singapore-2025
The Ophthalmologists Power List 2025: https://for.sg/opthalmologists-power-list-2025

Singapore General Hospital
Changi General Hospital (CGH)
Sengkang General Hospital
Eastern General Hospital
KK Women's and Children's Hospital
National Cancer Centre Singapore
National Dental Centre Singapore - NDCS
National Heart Centre Singapore
National Neuroscience Institute
Singapore National Eye Centre / Singapore Eye Research Institute
SingHealth Community Hospitals
SingHealth Polyclinics
Duke-NUS Medical School
SingHealth



Visit Academic Medicine Research Institute - AMRI at https://www.singhealthdukenus.com.sg/research

Following their success in securing S$60 million through the NMRC Open Fund - Large Collaborative Grant (OF-LCG), we cau...
18/12/2025

Following their success in securing S$60 million through the NMRC Open Fund - Large Collaborative Grant (OF-LCG), we caught up with the three teams behind CLARION, SPARKLE and MAGNET to learn what drives their and how they are turning scientific discovery into real-world impact. ✨

From tackling lung cancer, Parkinson’s disease to sarcopenia, these programmes reflect our collective commitment within the SingHealth Duke-NUS Academic Medical Centre to translate into better prevention, diagnosis and treatment. 🧠💪🔬

👉 Scroll through to hear from Assoc Prof Daniel Tan, Prof Tan Eng King and Prof Wang Yibin as they share how their teams are advancing to transform care and improve lives!

National Cancer Centre Singapore, National Neuroscience Institute, Duke-NUS Medical School, Sengkang General Hospital, Changi General Hospital (CGH), SingHealth, Agency for Science, Technology and Research (A*STAR), National University Cancer Institute, Singapore - NCIS, Nanyang Technological University, Singapore, National University of Singapore



Visit Academic Medicine Research Institute - AMRI at https://www.singhealthdukenus.com.sg/research

16/12/2025

🎥 What’s next for YOUR research in AMRI?

We caught up with a few of our SingHealth Duke-NUS Publish! Award and Research Team Award winners to uncover the exciting chapters coming up next in their AMRI journey 🕵️‍♂️ . From bold ideas to deeper collaboration, their insights pave the way forward for .

Hear what they have to say as we shape the future of together!

Sean Lam, Eugenia Ong, Frederick Koh, Alvin Ngeow

SingHealth
Sengkang General Hospital
Singapore General Hospital
Duke-NUS Medical School



Visit Academic Medicine Research Institute - AMRI at https://www.singhealthdukenus.com.sg/research

In this interview, Assoc Prof Andrea Kwa reflects on how bedside questions sparked her path from pharmacy practice into ...
11/12/2025

In this interview, Assoc Prof Andrea Kwa reflects on how bedside questions sparked her path from pharmacy practice into hashtag at Singapore General Hospital.

Today, she applies pharmacokinetics and pharmacodynamics to develop precision strategies against antimicrobial resistance (AMR). 🧫

“There is no one-size-fits-all solution for resistance bacterial infections. Each patient’s journey is different, and research is key to finding the right approach.” – Assoc Prof Andrea Kwa

Catch the full interview here: https://for.sg/interview-with-assoc-prof-andrea-kwa

Congratulations to Assoc Prof Sean Lam Shao Wei, Deputy Director, SingHealth Health Services Research Centre (HSRC) and ...
09/12/2025

Congratulations to Assoc Prof Sean Lam Shao Wei, Deputy Director, SingHealth Health Services Research Centre (HSRC) and Prof Emile John Tan Kwong Wei, Head and Senior Consultant, Department of Colorectal Surgery at Singapore General Hospital and National Cancer Centre Singapore for receiving the Finalists certificate for 2025 Pierskalla Best Paper Award by the Health Applications Society (HAS) of Institute Operations Research and Management Sciences (INFORMS)! ⭐

Named after Dr William Pierskalla, this award highlights Assoc Prof Lam’s and Prof Tan’s contribution to healthcare operations and their commitment to advancing data-driven solutions that improve patient care.

In the winning paper “Optimizing Initial Screening for Colorectal Cancer Detection with Adherence Behavior”, both researchers and their collaborators found that the optimal design of cutoffs for first-stage screening can significantly enhance screening effectiveness while reducing unnecessary colonoscopies and improving follow-up adherence.

Collaborators: Sarah Yini Gao, Yan He, Ruijie Zhang and Zhichao Zheng

Singapore Management University
ShanghaiTech University

A proud moment for our researchers and their collaborators – well done! 🎊



Visit Academic Medicine Research Institute - AMRI at https://www.singhealthdukenus.com.sg/research

  Population ageing is a phenomenon worldwide, and a whole-of-society approach needs to be in place to support healthy a...
08/12/2025

Population ageing is a phenomenon worldwide, and a whole-of-society approach needs to be in place to support healthy ageing.

Researchers from Singapore General Hospital, National Cancer Centre Singapore, Duke-NUS Medical School conducted a study to describe the development, implementation, and early outcomes of HealthStart – an intergenerational, layperson-led health coaching programme – and summarise operational lessons to guide similar models in Asian communities.

Their findings showed that HealthStart significantly improved primary care follow-up among older adults and highlighted key lessons for scaling similar programmes. These included the importance of rigorous volunteer selection and training, tailoring coaching intensity to participant readiness, tapping on community assets for sustainability, embedding social prescribing to address wider determinants of health, aligning closely with national population health policies such as Healthier SG, and cultivating meaningful intergenerational relationships that benefit both volunteers and participants.

Read more in JMIR Formative Research: https://bit.ly/46NPW5M

AMC researchers involved: Xiaoting Huang, Shu Ting, Audrey Kwan, Pei Zhen, Lynn Teo, Nerice, Hui Wen Ngiam, Si Qi Lim, Jaichandra Kharuna, Lian Leng Low, Kennedy Yao Yi Ng

Collaborators: Ka Shing Yow (National University Health System - NUHS), Jin Ye Yeo, Jie Xin Lim, Meng Han Lim, Aaron Tang (TriGen Singapore), Haikel Lim, Angeline Tey (National Healthcare Group (NHG))

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Visit Academic Medicine Research Institute - AMRI at https://www.singhealthdukenus.com.sg/research

  Older adults are often faced with a multitude of physical and social challenges that impede their ability to age healt...
04/12/2025

Older adults are often faced with a multitude of physical and social challenges that impede their ability to age healthily. Youth community health volunteers (YCHVs) are an untapped resource to support healthy ageing.

Researchers from Singapore General Hospital, SingHealth Community Hospital, National Cancer Centre Singapore, SingHealth and Duke-NUS Medical School conducted purposive sampling and carried out semi-structured interviews with 16 YCHVs and eight healthcare volunteers. Data were analysed thematically using deductive and inductive coding.

The findings revealed four key themes integral to YCHVs’ volunteering experience: (1) Providing relevant training, resources, and guidance were essential to equipping YCHVS’ with the knowledge and skills to conduct health coaching; (2) We better understand the challenges (e.g., finding common interests) and enablers (e.g., building rapport) that hindered or supported their volunteering experience; (3) It is key to have healthcare mentors to empower YCHVs; and (4) Understanding and addressing YCHVs’ motivations and goals allowed us to create more satisfactory volunteer experiences.

This study demonstrated the potential benefits of incorporating youth volunteers into preventive health strategies, whilst insights from their experiences may inform the design of future health coaching interventions.

Read more in BMJ Public Health, BMJ Journals: http://bit.ly/46qa9gI

AMC researchers involved: Jasmine Yee Ru Cheng, Audrey Shu Ting Kwan, Jed Jasman, Si Qi Lim, Thaddeus Chi En Cheong, Nerice Heng Wen Ngiam, Muhammad Razzan Razaki, Xiaoting Huang, Lynn Pei Zhen Teo, Sheryl Wen Ning Ho, Zi Hao Lee, Kharuna Jaichandra, Kennedy Yao Yi Ng, Lian Leng Low

Collaborators: Ka Shing Yow (National University Health System - NUHS), Jie Xin Lim (Nanyang Technological University, Singapore), Elliott Weizhi Sim, Alicia Shi Yao Chee (TriGen) Natasha Howard (National University of Singapore)



Visit Academic Medicine Research Institute - AMRI at https://www.singhealthdukenus.com.sg/research

A world-first breakthrough in rare-disease detection ➡️ Using electronic health records to spot the invisible.What if we...
01/12/2025

A world-first breakthrough in rare-disease detection ➡️ Using electronic health records to spot the invisible.

What if we could turn a 6-year diagnostic odyssey into a routine clinical alert?

For patients with rare diseases, the journey to a diagnosis is often a painful marathon of uncertainty, misdiagnosis, and countless specialist visits. This delay is a critical gap in modern healthcare, preventing timely access to potentially life-altering treatments and support.

Tudor Groza, co-lead for AI & Data Science from the Maternal and Child Health Research Institute (MCHRI) at KK Women's and Children's Hospital and Agency for Science, Technology and Research (A*STAR) Bioinformatics Institute (A*STAR BII), and Saumya Jamuar, the Genomics lead at MCHRI, have developed a novel method that analyses electronic health records (EHR) to identify patients at high risk of a rare disease --- years earlier than the current norms.

By leveraging a concept called Information Content, the method gives a weighted score specific to the patient’s presentation with symptoms at each visit in a patient's record. A high score acts as an early warning signal for clinicians.

In a landmark study of over 3 million records among 1.2 million Singapore patients over 4 years, this method proved it can achieve nearly 95% sensitivity, making it a robust approach to catch what might otherwise been missed.

Importantly, this is a scalable, cost-effective method that enables earlier identification of complex cases using data-driven insights that integrate seamlessly into existing EHR workflows --- without added administrative burden. With more like-minded teams collaborating, the method can be honed to derive the most appropriate value-based care plans

This is the first application of information-theoretic methods on EHRs for rare-disease screening, showing how can translate directly into better patient outcomes.

Learn more about this study that transforms rare disease diagnostics and makes the excruciating diagnostic odyssey a thing of the past!

Interested in Health Services Research but unsure where and how to start? 🤔The SingHealth Duke-NUS HSR Apprenticeship Pr...
28/11/2025

Interested in Health Services Research but unsure where and how to start? 🤔

The SingHealth Duke-NUS HSR Apprenticeship Programme (SHAPE) Fellowship is now open for registration till 28 December 2025, 5pm!

This 12-month programme pairs you with a dedicated mentor to guide you in thriving in Health Services Research. Successful applicants will be notified by the Programme Administrator within 1 month after the submission deadline with more information.

📝 Apply now at https://for.sg/shape-application-form
📄 For more details: https://for.sg/shape-proposal

The SingHealth Technology Incubator (SCOUT) was delighted to be part of the  , organised by Zühlke Group. It was a valua...
27/11/2025

The SingHealth Technology Incubator (SCOUT) was delighted to be part of the , organised by Zühlke Group. It was a valuable opportunity to connect with leaders across the health ecosystem and exchange ideas on how and innovation can drive a more sustainable future.

We were also pleased to have HiCura (a SingHealth-affiliated spin-off represented by Mr Joshua Chen, COO) and AEON (an innovative AI project led by Asst Prof Andrew Chou, principal investigator, KK Women's and Children's Hospital) who joined us to showcase their and innovation.

Thank you to everyone who visited us at the Innovation Zone. We look forward to more opportunities to co-create, connect and accelerate translational and innovation together!

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