Academic Medicine Research Institute - AMRI

Academic Medicine Research Institute - AMRI ​The Academic Medicine Research Institute (AMRI) is a one-stop research enabler that provides admi

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkins...
11/02/2026

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson’s disease, the second most common human neurodegenerative disease. Although the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson’s disease is still unclear, the advancement of stem cell approaches has shown promise for Parkinson’s disease research and therapy.

Researchers from National Neuroscience Institute and Duke-NUS Medical School discussed the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem cells.

They concluded that the discovery of current stem cell techniques for deriving induced pluripotent stem cells (iPSCs) from differentiated cells and further differentiation into distinct lineages of cells has opened new avenues of research, including in the field of neurobiology.

Read more in Neural Regeneration Research, Wolters Kluwer: https://bit.ly/46LlKZ6

AMC researchers involved: Ling-Xiao Yi, Genevieve Saw, Li Zeng, Eng King Tan, Zhi D**g Zhou



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Congratulations to Clin Assoc Prof Eugene Wong, Senior Consultant, Gastroenterology and Hepatology at Changi General Hos...
09/02/2026

Congratulations to Clin Assoc Prof Eugene Wong, Senior Consultant, Gastroenterology and Hepatology at Changi General Hospital (CGH) on achieving this outstanding research milestone. 👏

For years, clinicians have long worried that a group of hepatitis C medicines (protease-inhibitor antivirals) might worsen liver failure in people with advanced cirrhosis, especially since liver transplantation is not available or suitable for many patients worldwide.

In the largest multinational real-world study to date, spanning patients from the USA, Europe, and Asia; Clin Asst Prof Wong and his collaborators helped to close this critical knowledge gap. Their study showed very high cure rates and similar safety outcomes regardless of treatment type, with no increased risk of liver worsening, complications, cancer, or death.

Importantly, the findings suggest that a carefully selected subgroup of patients with decompensated cirrhosis—particularly those with MELD scores below 15—may reasonably consider protease-inhibitor treatment when access to liver transplantation is limited.

This impactful work titled “Real-world treatment outcome with protease inhibitor direct-acting antiviral in advanced hepatitis C cirrhosis: a REAL-C study” has been recognised as the Best Publication of Hepatology International by the Asia Pacific Association for the Study of Liver (APASL). Clin Asst Prof Wong also recently shared these insights with the global community at the APASL Hepatology Webinar: The Best Publication of Hepatology International.

Read more: https://pubmed.ncbi.nlm.nih.gov/37273170/



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Join us as we begin the 2026 RGR series with Translational Cardiovascular Research for Patient Benefit – Progress throug...
06/02/2026

Join us as we begin the 2026 RGR series with Translational Cardiovascular Research for Patient Benefit – Progress through Collaboration!

Mark your calendars: 25 Feb 2026, 12.30pm - 1.30pm
Be part of the conversation: https://for.sg/rgr25feb

Swipe through for more and don’t miss the publication recommendations in the comments! 👉📑

Prof Derek Hausenloy
Asst Prof Chrishan Ramachandra
Prof Wang Yibin

National Heart Centre Singapore
Duke-NUS Medical School
SingHealth

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The Catalyst Grant is awarded by the Communicable Diseases Agency (CDA), and it aims to foster collaborative research be...
05/02/2026

The Catalyst Grant is awarded by the Communicable Diseases Agency (CDA), and it aims to foster collaborative research between clinicians and scientists, and between hospitals, research centres, and academic institutions.

Applicants should have an awareness of the feasibility to complete the study within 12 months, including meeting ethics and research agreement requirements, as extension requests will be largely unsupported without compelling reasons. Inter-departmental collaborations within the same organisation will not be considered for funding.

Click to read more on the background, research scope, eligibility, submission or application procedure, and evaluation criteria: https://for.sg/cda-cataylst-grant



Visit Academic Medicine Research Institute - AMRI at https://www.singhealthdukenus.com.sg/research and watch this space for more grant calls!

The prevalence and economic burden of asthma across the public healthcare landscape in Singapore is substantial, where...
03/02/2026

The prevalence and economic burden of asthma across the public healthcare landscape in Singapore is substantial, where the asthma patient journey often transitions between primary care (PC) and specialty care (SC) settings.

Researchers from Singapore General Hospital and Duke-NUS Medical School conducted a study using the SingHealth Chronic Obstructive Pulmonary Disease (COPD) and Asthma Data Mart, a repository of clinical and administrative data from patients with asthma or chronic obstructive pulmonary disease, to collect real-time, real-world data across a range of demographics, disease severities and treatment pathways.

Their results provided a greater understanding of the asthma public healthcare landscape in Singapore, allowing for the identification of current gaps in care, particularly for high-risk groups that may benefit from optimised treatment.

Read more in Respiratory Medicine, Elsevier: https://bit.ly/3INy5Tx

AMC researchers involved: Mariko Siyue Koh, Sean Shao Wei Lam, Jun Tian Wu, Marcus Eng Hock Ong, Ngiap Chuan Tan, Chian Min Loo, David Bruce Matchar

Collaborators: Xiaomeng Xu, Priyan Ratnasingham, Ricco Marsel (GSK Singapore)



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Can a wallet-sized device save a life? With Out-of-Hospital Cardiac Arrest (OHCA) cases rising in Singapore, a team o...
30/01/2026

Can a wallet-sized device save a life?

With Out-of-Hospital Cardiac Arrest (OHCA) cases rising in Singapore, a team of researchers in Singapore, led by Prof Marcus Ong at Singapore General Hospital are transforming how communities respond to emergencies.

In 2015, the CPRcard, a credit-card-sized device providing real-time CPR feedback empowered volunteers to act quickly and confidently. A decade later, we have upgraded the CPRcard to integrate with SCDF’s myResponder app, via the TCPR Link SG , allowing dispatch nurses to guide bystanders 'real time' during resuscitation.

Early results from this large-scale proof-of-concept research study show that these technology-driven interventions can improve CPR quality, strengthen community preparedness, and increase survival outcomes.

From a simple wallet-sized device to a fully connected emergency response system, this innovation is putting lifesaving power in everyone’s hands, proving that even small tools, backed by , can transform outcomes.

⬅️ Swipe for more!

Fluctuations in weather and air quality can significantly affect asthma control. Researchers from Singapore General Ho...
28/01/2026

Fluctuations in weather and air quality can significantly affect asthma control.

Researchers from Singapore General Hospital SingHealth Polyclinics and Duke-NUS Medical School evaluated the association between asthma-related emergency department (ED) visits and weather, air quality, monsoons, haze, and cultural festivals in Singapore. They performed a retrospective observational study on patients with asthma seen across the public healthcare continuum between 2016-2024.

Their findings concluded that Pollution Standards Index (PSI)-ED association peaked on the same day of exposure but was no longer significant after adjusting for demographic and clinical factors. However, pollution-linked festivals such as Qingming, Hungry Ghost, and Mid-Autumn festivals where incense burning is prevalent, asthma ED visits nearly doubled even though PSI increased only marginally. Transboundary haze, and the Northeast monsoon were associated with increased asthma ED visits.

Read more on BMJ Open: https://bit.ly/45mf3vj


AMC researchers involved: Ming Ren Toh, Xingdi Wen, Gerald Xuan Zhong Ng, Adam Quek Rop Fun, Puan Youxin, Liesel Fong, Jun Tian Wu, Marcus Eng Hock Ong, David Bruce Matchar, Ngiap Chuan Tan, Chian Min Loo, Mariko Siyue Koh, Shao Wei Lam.

Collaborators: Aziz Sheikh (University of Oxford, UK)

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The PRECISE-SG100K resource is a unique multi-ancestry Asian population cohort dataset comprising ~100,000 Singaporean m...
27/01/2026

The PRECISE-SG100K resource is a unique multi-ancestry Asian population cohort dataset comprising ~100,000 Singaporean men and women. The resource provides an opportunity to advance precision medicine and related health research, in Singapore, Asia and the world.

Building on the success of Call for Proposals in 2024 (CFP 2024), and in anticipation of releasing baseline data for all ~100,000 participants, PRECISE-SG100K is planning a second Call for Proposals (CFP 2026). Upon launch of this Call, researchers in Singapore are invited to submit proposals that make use of the unique PRECISE-SG100K dataset to advance scientific knowledge and clinical translation.

Click to read more on the background, eligibility, funding details, submission or application procedure, evaluation criteria, and timelines: https://for.sg/precise-sg100k



Visit Academic Medicine Research Institute - AMRI at https://www.singhealthdukenus.com.sg/research and watch this space for more grant calls!

DREAM 4 Health is calling for proposals for Southeast Asian-led Multi-Country research consortia that address regional a...
27/01/2026

DREAM 4 Health is calling for proposals for Southeast Asian-led Multi-Country research consortia that address regional and global health challenges.

The objective of the SEA DREAM Programme is to fund regional consortia to produce excellent and outcome focused discovery and translational research that addresses existing and emerging national and regional health priorities.

The SEA DREAM programme is implemented by the SEAMEO Secretariat, in strategic partnership with the Wellcome Trust and the UK Foreign Commonwealth and Development Office (UK FCDO). Additional strategic partnerships with funders from across the region are anticipated for the SEA DREAM programme to amplify the impact towards transformative change in the regional research ecosystem.

Click to read more on the background, research scope, eligibility, submission or application procedure, and evaluation criteria: https://for.sg/dream-4-health



Visit Academic Medicine Research Institute - AMRI at https://www.singhealthdukenus.com.sg/research and watch this space for more grant calls!

Interested in finding out how CArdiovascular DiseasE National Collaborative Enterprise (CADENCE) and patient-specific in...
23/01/2026

Interested in finding out how CArdiovascular DiseasE National Collaborative Enterprise (CADENCE) and patient-specific induced pluripotent stem cells (iPSCs) disease-modelling platform are accelerating cardiovascular research and innovation?

Join Prof Derek Hausenloy, Asst Prof Chrishan Ramachandra and Prof Wang Yibin as they share how these developments are accelerating cardiovascular and innovation.

Sign up now at https://for.sg/rgr25feb or scan the QR code in the image below!

National Heart Centre Singapore
Duke-NUS Medical School
SingHealth



Visit Academic Medicine Research Institute - AMRI at https://www.singhealthdukenus.com.sg/research

Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), and Parkinson’s disease dementia (PDD) collectively represe...
20/01/2026

Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), and Parkinson’s disease dementia (PDD) collectively represent the majority of dementia cases worldwide. While these subtypes share clinical, genetic, and pathological features, their transcriptomic similarities and differences remain poorly understood.

Researchers from National Neuroscience Institute and Duke-NUS Medical School conducted a study to investigate cell type-specific gene expression patterns and pathways underlying pathological similarities and differences across dementia subtypes.

Their findings provided novel insights into the cell type-specific role of microglial MSR1 in AD, DLB, and PDD, linking its increased phagocytic capacity to myelin defects as a common feature of neurodegenerative dementias.

Read more in Genome Medicine, BMC: https://bit.ly/46TwPXY

AMC researchers involved: Chia Sook-Yoong, Li Zhihong, Tan Eng-King, Tu Haitao, Jolene Wei Ling Lee, Qiu Lifeng, Salvatore Albani, Adeline Su Lyn Ng, Chen Jinmiao, Zeng Li

Collaborators: Li Mengwei, Ling Jingjing (Agency for Science, Technology and Research (A*STAR)), Richard Reynolds (Nanyang Technological University, Singapore)

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The human fetal environment was previously thought to be predominantly suppressive and incompatible for T effector mat...
16/01/2026

The human fetal environment was previously thought to be predominantly suppressive and incompatible for T effector maturation.

Researchers from SingHealth Duke-NUS Translational Immunology Institute (TII), KK Women's and Children's Hospital and Duke-NUS Medical School employed a high parametric, mass cytometry–based approach to study the fetal circulatory and tissue immunomes.

Their findings provided evidence of a fetal regulatory environment that is permissive for T effector maturation, in part contributed by the relative instability and hypofunctionality in fetal Tregs.

Read more about human fetal immunology and inflammation, PNAS: http://bit.ly/3Wvfuyw

AMC researchers involved: Jing Yao Leong, Martin Wasser, Pavanish Kumar, Shi Huan Tay, Sharifah Nur Hazirah, Joo Guan Yeo, Xiu Qi Tan, Nursyuhadah Sutamam, Farah Nadiah Azman, Camillus Jian Hui Chua, Phyllis ZiXuan Chen, Fauziah Ally, Lakshmi Ramakrishna, Su Li Poh, Liang Xie, Yiping Fan, Thaschawee Arkachaisri, Jerry Kok Yen Chan, Florent Ginhoux, Salvatore Albani

Collaborators: Naomi McGovern, Archita Mishra (Agency for Science, Technology and Research (A*STAR)), Charles-Antoine Dutertre (Gustave Roussy Cancer Campus), David Vermijlenl, Catherine Donner, Maria Papadopoulou (ULB - Université libre de Bruxelles)



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