Integrative Kidney Institute, بناء المهندسن ساحة المحافظهBuilding Engineers Square Mun, Damascus (2026)

16/02/2026

🧪 New Research Insight: Inflammation May Be the Missing Prognostic Signal in CKD

What if kidney disease progression isn’t just about eGFR… but about inflammatory identity?

A large prospective study in stage 3 CKD followed patients for up to 10 years and found that specific inflammatory cytokines strongly predicted:

📌 Faster worsening of albuminuria
📌 Progression to kidney failure
📌 Cardiovascular events
📌 All-cause mortality

The strongest signals came from TNF-α, GDF-15, and IL-22.

Researchers identified six distinct inflammatory “profiles.”
Patients with the highest inflammatory burden had the worst renal and cardiovascular outcomes, while those with low cytokine activity had the slowest CKD progression and best survival.

Even more concerning:

➡️ Many patients shifted into more inflammatory profiles over time, suggesting that inflammation accelerates as CKD advances.

This raises an uncomfortable but necessary question:

Are we underestimating inflammation as a primary driver of kidney decline?
And if so, why aren’t we measuring it more intentionally?

These findings support a future where CKD care moves beyond one-size-fits-all staging and toward:

✔️ Early identification of high-risk inflammatory phenotypes
✔️ More personalized, anti-inflammatory strategies
✔️ Better prediction of who will progress — and who may not

We’d love your thoughts:

📌Should inflammatory biomarkers play a larger role in CKD risk stratification?
📌 How might this change how we monitor or treat earlier-stage CKD?
📌 What anti-inflammatory strategies have you found most impactful in practice?

Read the study here: [https://f.mtr.cool/ixhqdrhfxf

Let’s discuss below 👇

15/02/2026

Blog highlight 📘

“Demystifying Oxalate: The Antinutrient Unveiled”

The gut microbiome plays a critical role in oxalate handling. Certain bacteria, including Oxalobacter formigenes, can actively degrade oxalate in the intestine, reducing how much is absorbed and ultimately excreted in the urine.

When these microbes are depleted — due to antibiotics, gut dysbiosis, or chronic inflammation — oxalate absorption increases, even if dietary intake stays the same.

This helps explain why two people can eat identical diets and have very different oxalate stone risk. It also shifts the conversation from restriction to restoration: supporting gut health may be just as important as modifying food choices.

Have you ever noticed stone risk increase after antibiotics or GI issues?

Curious how probiotics or diet diversity fit into oxalate management?

Let’s discuss 👇🧬🦠

Read the blog here: [https://f.mtr.cool/nfpthwaimm

14/02/2026

Blog highlight 📘

“Demystifying Oxalate: The Antinutrient Unveiled”

This is one of the most misunderstood concepts in kidney stone prevention.

A significant portion of urinary oxalate is generated by the liver from amino acids and collagen, not just from high-oxalate foods.

This explains why aggressive food restriction alone often fails and why metabolic health, protein balance, gut function, and micronutrients matter just as much as what’s on the plate.

How often do you see patients blamed for diet alone when the issue is metabolic?

What questions do you have about oxalate handling?

Let’s talk 👇🧠🧬

Read the blog here: [https://f.mtr.cool/bfqatidzgg

13/02/2026

🧂 Sodium Intake: Why It’s Not One-Size-Fits-All

Sodium plays a vital role in fluid balance, nerve signaling, and blood pressure control, but how much is too much or too little? That depends on your kidney health.

🔍 In the general population, both high and very low sodium intake are linked to increased cardiovascular risk and mortality. Too much sodium raises blood pressure and damages vessels. But too little can trigger stress hormones like renin and catecholamines, leading to vascular dysfunction.

⚠️ In patients with chronic kidney disease (CKD), the picture shifts:

High sodium intake (>5g/day) is consistently associated with:
Elevated blood pressure
Increased proteinuria
Faster CKD progression
Greater cardiovascular risk
Low-to-moderate sodium intake (under 2g/day) does not carry the same cardiovascular risks in CKD as it does in the general population—though excessive short-term restriction may reduce eGFR temporarily.
🔑 Key distinction:
▶️ In the general population, both ends of the spectrum—too high or too low—are risky.
▶️ In CKD, only high sodium intake has clear links to poor outcomes.

📉 For CKD patients, reducing sodium to

13/02/2026

Unlock the Secrets to Kidney Health! 🌿

Ever wondered which supplements truly make a difference for your kidneys? Our guide reveals the Top 6 Essential Supplements for optimum kidney health! 🧪 Dive deep into the science behind each choice and understand the 'why' and 'how much' for your daily intake.

But remember, everyone's unique. ✨ For the perfect dosage tailored to you, make sure to consult your nephrologist and a specialist in functional or integrative nutrition.

Ready to embark on a kidney-healthy journey? [link in profile]

🔗 https://inkidney.com/product/six-essential-supplements-for-kidney-health/

12/02/2026

Blog highlight 📘

“Demystifying Oxalate: The Antinutrient Unveiled”

Oxalate is often blamed as a dietary villain, especially in kidney stone prevention, but this blog explains why that framing is incomplete.

Most urinary oxalate does not come directly from food alone, and the amount absorbed depends on gut health, mineral pairing, food preparation, and individual metabolism.

Calcium and magnesium intake, cooking methods like boiling, and overall dietary balance can significantly reduce oxalate absorption and stone risk without unnecessary food restriction.

How do you approach oxalate in patients with kidney stones or CKD?

Do you focus on elimination, pairing, or personalization?

Questions and perspectives welcome below 👇🧠🥬

Read the blog here: [https://f.mtr.cool/fzpbsuergi

11/02/2026

Blog highlight of today 🦠🩺

“Exploring the Role of Postbiotics in Enhancing Kidney Health”

This blog explores why the conversation is moving beyond probiotics to postbiotics and why that matters for kidney disease.

Postbiotics, the bioactive compounds produced by gut microbes, can reduce inflammation, counter oxidative stress, and limit gut-derived uremic toxins that burden the kidneys.

This makes them especially relevant in CKD, where gut dysbiosis and systemic inflammation accelerate disease progression.

Have you considered postbiotics in kidney or metabolic care?

Which gut-focused strategies have you found most helpful for patients?

Let’s discuss 👇💬

Read the blog here: [https://f.mtr.cool/pffntuoewx

10/02/2026

Can nutrition actually improve kidney function in ADPKD? 🧬🥑🫘

A new real-world study suggests it might.

In this longitudinal evaluation of 103 people with autosomal-dominant polycystic kidney disease (ADPKD), participants followed a structured ketogenic nutrition and lifestyle program supported by a citrate-based medical food (KetoCitra®).

After just 3 months, researchers observed:

• Sustained nutritional ketosis
• Significant reductions in BMI
• An average increase in eGFR of 6.3% 📈
• Reduced need for blood pressure medications
• Improvements in kidney pain and headaches
• Stable electrolytes, lipids, and acid–base balance

In short, kidney function improved without sacrificing metabolic safety.

Why this matters:

ADPKD has long been viewed as relentlessly progressive, with limited non-pharmacologic options. This study suggests that targeting metabolism, acid load, and lithogenic stress through ketogenic nutrition plus citrate support may meaningfully reduce kidney stress and improve function.

It adds momentum to a growing shift toward nutrition-based disease modification in ADPKD — not just symptom management.

Could metabolic therapy become a core pillar of ADPKD care?
What questions do you have about ketogenic nutrition or citrate support in kidney disease? 💬

Read the study here: [https://f.mtr.cool/rndvjoduzg

10/02/2026

✨ New on our Fullscript dispensary: Berberine UltraSorb by Pure Encapsulations ✨

Berberine is one of our favorite botanicals for metabolic and kidney health support.

It helps:

✅ Improve insulin sensitivity
✅ Support healthy lipid balance
✅ Reduce inflammation and oxidative stress
✅ Promote a healthy gut–kidney connection

Pure Encapsulations’ Berberine UltraSorb is formulated for enhanced absorption and gentle GI tolerance—making it ideal for those who want reliable results without stomach upset.

🩺 We often recommend berberine as part of an integrative plan for:

Early metabolic or diabetic kidney disease
Cardiometabolic risk reduction
Healthy weight and blood sugar management

You can now order it directly through our Fullscript dispensary with a 20% discount for our community.

🔗 [link in bio on Instagram] https://us.fullscript.com/plans/inkidney-berberine

Use the link to create your account and access all professional-grade supplements at exclusive pricing.

09/02/2026

What if cardiovascular–kidney–metabolic disease isn’t driven only by diet, genetics, or lifestyle—but by everyday toxin exposure? ⚠️🧪

A large NHANES-based study (1999–2018) found that higher urinary levels of common metals and metalloids—including barium, antimony, thallium, tungsten, cobalt, and arsenic—were linked to higher odds of cardiovascular–kidney–metabolic (CKM) syndrome and more advanced disease stages 🫀🧠🩺

Even more eye-opening 👀

• Mixed metal exposures were more harmful than any single metal alone
• Different metals mattered at different stages of CKM progression
• Inflammation, oxidative stress, and accelerated biological aging helped explain the link 🔥🧬⏳

This reframes CKM syndrome as more than a lifestyle disease. It may also be an environmentally driven condition shaped by cumulative, low-level exposures most people never think about 🌍🚱

Are we missing a major upstream driver of cardio–renal–metabolic disease by ignoring environmental toxicants?
Should toxin screening and exposure reduction be part of CKM prevention strategies?

Read the study here: [https://f.mtr.cool/kghoqnlsev

Drop your thoughts, questions, or clinical experiences below 👇💬

08/02/2026

Blog highlight of today 🚭🩺

“Smoking and Kidney Disease Progression Globally and in the US”

This blog breaks down how smoking acts as a powerful, independent driver of chronic kidney disease progression worldwide and in the US. From vascular injury and oxidative stress to toxic heavy metal exposure like cadmium, smoking places continuous strain on the kidney's blood flow and filtration.

The encouraging part?

Kidney risk begins to fall the longer someone remains smoke-free, making cessation one of the most impactful, modifiable interventions in kidney care.

How often do you discuss smoking as a kidney-specific risk factor with patients? Have you seen kidney outcomes improve after cessation?

Questions and reflections welcome 👇💬

Read the blog here: [https://f.mtr.cool/sutqzmviog

07/02/2026

New blog out today 🩺🥬

"Potassium Intake and Blood Pressure Control: The Critical Link You Need to Know"

For years, hypertension conversations have focused almost exclusively on sodium. But growing evidence shows potassium is just as important — and often overlooked.

This new blog breaks down why potassium is a powerful regulator of blood pressure through kidney sodium handling, hormonal signaling, vascular tone, and even the gut microbiome 🌱🧬.

A 2025 dose–response meta-analysis shows that increasing potassium intake can meaningfully lower blood pressure, especially in people with hypertension, with effects comparable to many lifestyle interventions.

We also explore:

• Why dietary potassium works differently from supplements

• How potassium promotes natriuresis and vasodilation

• Why the sodium-to-potassium ratio matters more than either alone

• Emerging links between potassium, gut microbes, and blood pressure

Have you ever focused on potassium intake in blood pressure or kidney care?

Do you use food-based strategies or supplements?

Share your questions or experiences below 👇

Read the blog here: [https://f.mtr.cool/rjgzmeibmi

Integrative Kidney Institute

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