10/10/2025
Thanks Katie!!
✨Top tips for diagnosing and managing opioid-induced neurotoxicity ✨
🤔 Think about opioid-induced neurotoxicity in any patient taking an opioid who develops:
💪🏻Myoclonus—uncontrollable twitching and jerking of muscles, usually forearms and hands
🫥 Delirium or other neuropsychiatric signs such as confusion, disorientation, drowsiness, reduced levels of consciousness, agitation, cognitive impairment, and/or visual or tactile hallucinations
😩 Increased pain, caused by things that don’t normally cause pain (allodynia) or an unexplained increase in generalised body pain (hyperalgesia)
👀 Pinpoint pupils can be seen but are not diagnostic on their own
✨Management✨
✅ if pain is controlled, reduce the opioid dose 👇
😵💫 For mild hallucinations, consider adding a small dose of an antipsychotic medication at night, such as Haloperidol. By doing so, you might be able to keep the opioid the same.
❌ If pain is not controlled, or side effects are intolerable, opioid switch ♻️
⭐️ in my next post, I will look at the importance of monitoring opioid-induced sedation
⭐️⭐️ if you enjoyed this, check out my other posts on opioid toxicity 👇
https://lnkd.in/gN-cJgPM
https://lnkd.in/gVNTDXPJ
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Hi 👋🏻 I’m Katie Weatherstone, a Palliative Medicine consultant in New Zealand
Follow me for topics related to palliative care and the experiences of patients with advanced illnesses, as well as those caring for them.