17/06/2025
關於如何預防 阿滋海默症 The Journal of Prevention of Alzheimer's Disease 在ELSEVIER期刊發表刊出的文章：列名第一作者。
論文標題Title：Adherence to an anti-inflammatory diet is associated with lower Alzheimer’s disease mortality: A modifiable risk factor in a national cohort
遵循抗發炎飲食與較低的阿茲海MER症死亡率相關：一個全國性世代研究中的可改變風險因子
論文大綱Abstract:
Background: Chronic neuroinflammation contributes to Alzheimer’s disease (AD) pathogenesis, and diet is a
modifiable factor influencing inflammation. The impact of an anti-inflammatory diet on AD-specific mortality
remains unclear.
Objectives: To examine the association between adherence to an anti-inflammatory diet (measured as the per-
centage of dietary energy from anti-inflammatory foods) and AD-specific mortality, as well as all-cause mortality,
in a large national cohort, and to determine whether associations differ by s*x or race/ethnicity.
Methods: We analyzed 18,795 U.S. adults ( ≥ 18 years) from the 2007–2014 National Health and Nutrition Ex-
amination Survey. Anti-inflammatory diet adherence was defined as the percentage of total energy intake from
anti-inflammatory foods, categorized as 0 %, < 5 %, 5–9.99 %, or ≥ 10 %. Outcomes were AD-specific mortality
and all-cause mortality ascertained via the National Death Index. Cox proportional hazards models were used to
estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for mortality across intake categories, adjusting
for demographic, lifestyle, and health factors. Analyses were stratified by s*x, race/ethnicity, and age ( ≥ 45 years
for AD mortality).
Results: Participants with 0 % anti-inflammatory intake had a higher all-cause mortality risk (HR 3.82, 95 % CI
1.18–12.33) compared to those with ≥ 10 % intake. In the overall analysis, 0 % anti-inflammatory intake showed a
trend of reduced AD-specific mortality although its did not reach statistical significance after full adjustment (HR
3.04, 95 % CI 0.74–12.46 vs. ≥ 10 % intake; p > 0.05). Notably, the inverse association between anti-inflammatory
diet and AD mortality emerged in subgroup analyses. Male participants and non-Hispanic White participants with
0 % intake had the highest AD mortality hazards (HR 12.83 and 3.77, respectively, vs. ≥ 10 % intake), indicating
significant risk reductions with anti-inflammatory diet in these groups. In contrast, no significant associations
were observed in female or non-White subgroups. Even a modest intake of anti-inflammatory foods ( ≥ 10 % of
感謝共同作者群：
許景琦 a,b, 王秀鶯 c,d, 余尚儒 f,g,h,i,*, 林世勳 j,k, 魏正宗 l,m,n,**
共同作者：
a 台灣台中市404022，Wizcare醫療法人集團董事會
b 台灣新竹市300044，國立清華大學國際博士班學程
c 台灣台中市402306，中山醫學大學附設醫院醫學研究部健康資料科學中心
d 台灣台中市402306，中山醫學大學健康照護管理學院健康政策與管理學系
e 台灣高雄市807378，高雄醫學大學醫學院皮膚科學系
f 台灣高雄市820111，高雄醫學大學附設高醫岡山醫院皮膚科
g 台灣高雄市807377，高雄醫學大學附設中和紀念醫院皮膚科
h 台灣台北市100025，國立台灣大學公共衛生學院公共衛生碩士學程
i 台灣高雄市807378，高雄醫學大學神經科學研究中心
j 台灣新竹市300044，國立清華大學經濟學系
k 台灣新竹市300044，國立清華大學EMBA/MBA/MFB/MPM/HBA學程
l 台灣台中市402306，中山醫學大學醫學研究所
m 台灣台中市402306，中山醫學大學附設醫院過敏免疫風濕科
n 台灣台中市406040，中國醫藥大學中西醫結合研究所
