27/09/2025
國際婦產科聯盟 (FIGO) 的官方聲明: 乙醯氨基酚 (acetaminophen) 在懷孕期間的使用與自閉症風險：證據不支持因果關係
孕期用藥原則，需平衡利與弊:
利: 控制疾病，避免因疾病控制不佳而影響懷孕 (例如感染、高血壓、糖尿病、免疫疾病等)
弊: 藥物對懷孕與胎兒的可能影響 (例如非類固醇抗發炎止痛藥 (NSAIDs) 在懷孕後期可能造成胎兒動脈導管提早關閉)
FIGO statement on Paracetamol (acetaminophen) use during pregnancy and autism risk: evidence does not support causal association
While some observational studies have suggested associations, these findings have fundamental methodological limitations, including recall bias, inadequate exposure characterisation, heterogeneous outcome assessment and insufficient control for confounding factors. Obstetric practice should be based on evidence-based medicine and careful evaluation of research methodology. Recent statements questioning paracetamol safety go against established scientific findings and may harm maternal and foetal health by discouraging use of this medication.
"As obstetric professionals, we should maintain our focus on evidence-based practice and advocate for our patients based on rigorous scientific research and proper evaluation of study quality." - Dr Frank Louwen, FIGO President-Elect
Healthcare providers should continue recommending paracetamol as the preferred analgesic during pregnancy when medically needed, counselling patients based on evidence while maintaining confidence in this medication's established safety profile.
Read the full statement here: https://www.figo.org/paracetamol-acetaminophen-use-during-pregnancy-and-autism-risk-evidence-does-not-support-causal
International Journal of Gynecology and Obstetrics
