General Pharmacology s.m

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Sodium citrate ❔🤔
09/02/2024

Sodium citrate ❔🤔

First order vs zero order metabolism kinetics
16/10/2022

First order vs zero order metabolism kinetics

Volume of distribution
16/10/2022

Volume of distribution

Distribution
16/10/2022

Distribution

Bioavailability*Bioavailability is the fraction of administered drug that reaches the systemic circulati1.First-pass hep...
11/10/2022

Bioavailability*Bioavailability is the fraction of administered drug that reaches the systemic circulati

1.First-pass hepatic metabolism: enicillin G, are
2.unstable in the pH of the gastric contents. Others, such as insulin,
are destroyed in the GI tract by degradative enzymes.
solubility -Hydrophilic drugs are poorly
absorbed because of their inability to cross the lipid-rich cell
membranes. Paradoxically, drugs that are extremely hydrophobic
are also poorly absorbed

Nature of drug formulation

Factors1.pH2.blood flow3.surface area4.contact time5.p-glycoprotein
11/10/2022

Factors
1.pH
2.blood flow
3.surface area
4.contact time
5.p-glycoprotein

Schematic representation of drugscrossing a cell membrane. ATP = adenosine triphosphate; ADP = adenosine diphosphate
11/10/2022

Schematic representation of drugs
crossing a cell membrane. ATP =
adenosine triphosphate; ADP =
adenosine diphosphate

Mechanism of drug absorption*Absorption is the transfer of a drug from its site of administration to the bloodstream
11/10/2022

Mechanism of drug absorption*Absorption is the transfer of a drug from its site of administration to the
bloodstream

Routes of drug administration
11/10/2022

Routes of drug administration

Absorption: First, drug absorption from the site of administration permits entry of the therapeutic agent (either direct...
11/10/2022

Absorption: First, drug absorption from the site of administration
permits entry of the therapeutic agent (either directly or indirectly)
into plasma.
• Distribution: Second, the drug may then reversibly leave the
bloodstream and distribute into the interstitial and intra cellular
fl uids.
• Metabolism: Third, the drug may be biotransformed by metabolism by the liver, or other tissues.
• Elimination: Finally, the drug and its metabolites are eliminated
from the body in urine, bile, or f***s.

Cyclic Adenosine Monophosphate Mediates the Effects of Parathyroid Hormone. A large share of the effect of PTH on its ta...
10/10/2022

Cyclic Adenosine Monophosphate Mediates the
Effects of Parathyroid Hormone. A large share of the
effect of PTH on its target organs is mediated by the
cyclic adenosine monophosphate (cAMP) second messenger mechanism. Within a few minutes after PTH
administration, the concentration of cAMP increases in
the osteocytes, osteoclasts, and other target cells. This

Ligand voltage -ion gated channels*
10/10/2022

Ligand voltage -ion gated channels*

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Kabale , Mbarara
Kabale

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