VectorGen, LLC

VectorGen, LLC VectorGen’s ultimate mission is to develop a delivery vehicle to confer therapeutic genetic materi

At present, despite an epidemic of staggering proportions, we have no pharmaceutical "cure" for the HIV virus. The Highly Aggressive Anti-Retroviral Therapy (HAART) has been inarguably effective at prolonging life and improving quality of life, but the fact that HIV can remain dormant in the genome in just about any tissue in the body, coupled with its capacity to rapidly change its antigenic determinants, makes a pharmacological side effects. We are proposing a completely innovative approach to gene therapy; an approach which builds on research from a number of sources. Our vector is designed to deliver its therapeutic cargo, and then conditionally repress its own replication. The therapeutic gene will be induced in the presence of "live" HIV; and will prevent the budding of HIV particles from infected cells, and destabilize the assembly of infectious HIV virions. The risk of generating a dangerous lentivirus through recombination is minimized by all but eradicating HIV sequences in the vector cargo, and by human-optimizing any sequences that overlap with the HIV genome. We plan to insert the transgene into the human genome site-specifically, to reduce the risk of oncogenic activation or other positional effects. We propose that this vector will confer lasting protection against HIV in uninfected, as well as infected individuals, after a single administration. As such, it would be a radical departure from traditional vaccine-based therapies, which have been slow to bear fruit in clinical trials. Finally, and equally important, the vector design may be used as a platform. The same auto-regulatory mechanism could be employed to combat any characterized virus.

Easiest knockout of my career.
05/15/2023

Easiest knockout of my career.

11/10/2020

Pleased to announce that I have begun work on a provisional patent application to protect VectorGen's genetic delivery mechanism.

We have a plan...and not quite enough time.

03/25/2020

VectorGen is looking to hire a Student Intern from Cornell University through the EaC Summer Internship Program.

03/25/2020

Sad to report that Concordia University has shuttered in the face of the COVID outbreak, so I will not be participating in the Industry panel on April 6th in person.

If the option is available, I will let you know how you can tune in by Zoom.

03/25/2020

Successfully completed an application for the Bioresearch Accelerator and Commercialization Center Academy, at Albany Medical College!

Fingers crossed.

Pictures of me at the IPhO Northeast Regional Meeting (NERM) 2020 | Albany, last Saturday. I had a great time meeting an...
03/08/2020

Pictures of me at the IPhO Northeast Regional Meeting (NERM) 2020 | Albany, last Saturday. I had a great time meeting and talking with some really bright people!
Thanks very much for inviting me to represent VectorGen on the Industry Panel!

Explore Laura Prendergast's 10 favorites on Flickr!

As if Bio-research were not technically challenging enough!
01/18/2020

As if Bio-research were not technically challenging enough!

I’m writing to introduce myself and a topic I would like to bring to the attention of the greater scientific community. I’ve attached an article to this post, in which I describe an emergent threat with considerable implications for human health, and for the Biotechnology research sector.

Donate to HIV cure research!Take this opportunity to visit our crowd-funding website: https://experiment.com/projects/an...
04/18/2018

Donate to HIV cure research!

Take this opportunity to visit our crowd-funding website: https://experiment.com/projects/an-in-vivo-delivery-system-for-hiv-cure-genetics, to learn about our cool project.

And be sure to share widely among friends and family.

Our mission is to develop a gene therapy to combat HIV. Our vector is intended to confer a therapeutic gene safely and permanently into living humans after a single administration, which activates during HIV infection to prevent release of HIV particles from infected cells, then represses its own...

Yesterday I write up an outreach letter to pitch our project to Angel Investors and Venture Capitalists. Do you know any...
03/28/2018

Yesterday I write up an outreach letter to pitch our project to Angel Investors and Venture Capitalists.

Do you know any?

Please make them aware of our crowdfunding work. Visit the link below to learn about the science of HIV cure research, and to contribute to this important project.

Our mission is to develop a gene therapy to combat HIV. Our vector is intended to confer a therapeutic gene safely and permanently into living humans after a single administration, which activates during HIV infection to prevent release of HIV particles from infected cells, then represses its own...

Contribute to HIV Cure Research.Help us reach our funding goal for vital proof-of-concept experimentation.
03/26/2018

Contribute to HIV Cure Research.
Help us reach our funding goal for vital proof-of-concept experimentation.

Our mission is to develop a gene therapy to combat HIV. Our vector is intended to confer a therapeutic gene safely and permanently into living humans after a single administration, which activates during HIV infection to prevent release of HIV particles from infected cells, then represses its own...

03/20/2018

Day two of launch.
Please consider a small donation to help fund critical research into a cure for the HIV virus. Visit our Experiment.com website to see the details of the project and learn about the science.

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5 Hall Place
Albany, NY
12210

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+19172911253

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