11/10/2025
Neuroendocrine Tumor Day — November 10
Neuroendocrine tumors (NETs) are uncommon, often slow-growing neoplasms that most frequently arise in the gastrointestinal tract and lungs, but can occur elsewhere (e.g., pancreas, liver, adrenal). Early recognition and accurate grading matter.
• Functional vs. non-functional: Functional NETs secrete hormones and cause hormone-related symptoms; non-functional NETs do not secrete hormones but can still impair organ function.
• Carcinoid syndrome: Flushing, diarrhea, cramping, and/or wheezing—often associated with serotonin-secreting tumors.
• Symptoms vary by site: Abdominal pain, bowel changes/obstruction, cough or wheeze, or incidental imaging findings.
• Classification: Neuroendocrine neoplasms (NEN) include well-differentiated NET and poorly differentiated NEC; biology can evolve with changes in grade, mitotic rate, and Ki-67.
If you have persistent flushing/diarrhea or unexplained abdominal or respiratory symptoms, talk with your clinician about evaluation.