04/06/2026
Botox resistance is a documented immunologic phenomenon affecting an estimated one to four percent of patients. Your body produces antibodies that neutralize the botulinum toxin before it reaches the neuromuscular junction. Dr. Deepa Macha at CosMedic LaserMD in Ann Arbor differentiates true resistance from common alternatives.
More commonly, what appears as resistance is actually under-dosing, subtle changes in injection placement over time, or collagen loss making skin appear less smooth despite effective muscle relaxation. Dr. Macha investigates the actual cause before changing your protocol.
If genuine resistance is confirmed, switching to Xeomin eliminates accessory proteins that trigger immune response. Taking a treatment break allows circulating antibodies to clear. CosMedic LaserMD adjusts strategy rather than simply increasing units.
You deserve answers, not just more product. Book your Botox reassessment at CosMedic LaserMD in Ann Arbor with Dr. Deepa Macha.
📍 CosMedic LaserMD Locations:
Ann Arbor — 4900 Jackson Road, Ann Arbor, MI 48103 — (734) 249-8722
Ann Arbor — 820 W Eisenhower Pkwy, Ann Arbor, MI 48103 — (734) 249-8722
🌐 https://cosmediclasermd.com
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