Dr. Jason Winkelmann

03/05/2026

Part 4: One of the most powerful pain receptors in your nervous system is the NMDA receptor.
When activated, it amplifies pain signals and contributes to central sensitization, the process where the nervous system becomes overly responsive.
Magnesium naturally regulates this receptor.
It:
• Helps control excess glutamate
• Blocks excessive calcium influx
• Reduces abnormal pain signaling
In fact, magnesium binds to this receptor at a significant percentage of the strength of ketamine—one reason it has been studied in CRPS and post-surgical pain reduction.
If you feel like your nervous system is “stuck on high,” this mechanism is critical.
In this video, I break down:
• How NMDA receptors amplify pain
• Why centralized pain persists even after tissue healing
• Why magnesium may reduce morphine requirements post-surgery

03/04/2026

Part 3: Did you know magnesium is required to convert plant-based omega-3s into their active anti-inflammatory forms?
Most people know EPA and DHA reduce inflammation. But if you rely on plant sources (ALA), your body must convert them, and that pathway requires magnesium-dependent enzymes.
Without adequate magnesium, this already inefficient process becomes even weaker.
For patients with chronic inflammation, autoimmune pain, or centralized sensitivity, this matters.
In this video, I explain:
• Why ALA must convert to EPA and DHA
• The magnesium-dependent enzymes in that pathway
• Why inflammation persists even when you “eat clean”
Magnesium doesn’t just relax muscles—it influences inflammatory chemistry at the enzymatic level.

03/03/2026

Part 2: If you have chronic pain and fatigue, magnesium may be affecting something deeper than muscle tension. It may be affecting your cellular energy.
ATP is your body’s energy molecule. But ATP is unstable on its own. Magnesium binds to ATP, stabilizing it so it can be transported to tissues that need repair.
No magnesium = inefficient energy delivery.
And when energy production is compromised, tissue repair slows. Pain lingers. Recovery stalls.
If you’ve tried magnesium but “didn’t feel more energy,” it may not be about energy in the way you think. It may be about tissue healing and mitochondrial stability.
In this video, I explain:
• Why magnesium is required for ATP stability
• The connection between fatigue and chronic pain
• Why bioavailability matters more than brand names

03/02/2026

Part 1: If you live with chronic pain and constantly tight, achy muscles, magnesium may be one of the most overlooked pieces of the puzzle.
Magnesium is not just “a supplement for cramps.” It directly regulates muscle contraction at the cellular level. When calcium binds inside your muscle fibers, the muscle contracts. Magnesium is what displaces calcium so the muscle can relax.
If you feel like your body is always braced, guarded, or stuck in tension—even when imaging is normal—this mechanism matters.
But here’s the key: form and dosing determine whether magnesium actually works.
In this video, I break down:
• Why magnesium is nature’s muscle relaxer
• How calcium-magnesium balance affects chronic pain
• Why many people say “magnesium didn’t work for me”

03/01/2026

https://www.mytruehealthcenters.com/post/fat-and-chronic-pain

Discover why dietary fat is misunderstood and how it affects inflammation, mitochondrial energy, and nerve sensitivity in chronic pain.

02/28/2026

Putting it all together. Fat is an essential nutrient for healing all chronic pain conditions. But the wrong kind can make things much worse.

Dietary fat has been misunderstood for decades, yet it plays a critical role in chronic pain recovery. In this video, I explain why healthy fats are essentia...

02/27/2026

Part 5: Chronic pain isn’t just structural. It’s metabolic, inflammatory, and neurological.

Dietary fat plays a critical role in:
• Energy production
• Inflammation
• Cell membrane integrity
• Nerve health
• hormone production

Low-fat diets can disrupt healing, increase pain sensitivity, and impair recovery in people with chronic pain and fatigue.

In this video, I break down why healthy fats are essential for chronic pain treatment and what this means for your nutrition strategy.

02/26/2026

Part 4: Chronic pain isn’t just structural. It’s metabolic, inflammatory, and neurological.

Dietary fat plays a critical role in:
• Energy production
• Inflammation
• Cell membrane integrity
• Nerve health
• hormone production

Low-fat diets can disrupt healing, increase pain sensitivity, and impair recovery in people with chronic pain and fatigue.

In this video, I break down why healthy fats are essential for chronic pain treatment and what this means for your nutrition strategy.

02/24/2026

Part 2: Chronic pain isn’t just structural. It’s metabolic, inflammatory, and neurological.

Dietary fat plays a critical role in:
• Energy production
• Inflammation
• Cell membrane integrity
• Nerve health
• hormone production

Low-fat diets can disrupt healing, increase pain sensitivity, and impair recovery in people with chronic pain and fatigue.

In this video, I break down why healthy fats are essential for chronic pain treatment and what this means for your nutrition strategy.

02/23/2026

Part 1: Chronic pain isn’t just structural. It’s metabolic, inflammatory, and neurological.

Dietary fat plays a critical role in:
• Energy production
• Inflammation
• Cell membrane integrity
• Nerve health
• hormone production

Low-fat diets can disrupt healing, increase pain sensitivity, and impair recovery in people with chronic pain and fatigue.

In this video, I break down why healthy fats are essential for chronic pain treatment and what this means for your nutrition strategy.

02/20/2026

Putting it all together. Chronic pain and the fatigue that comes with it is not a matter of willpower and no amount of rest is going to improve it. This is a cellular problem with proven treatments.

Chronic pain and fatigue are not a rest issue. They are not a willpower issue either. They are a mitochondria problem. Learn the basics of mitochondria dysfu...

02/20/2026

Part 3: Chronic pain isn’t just structural. It’s metabolic, inflammatory, and neurological.

Dietary fat plays a critical role in:
• Energy production
• Inflammation
• Cell membrane integrity
• Nerve health
• hormone production

Low-fat diets can disrupt healing, increase pain sensitivity, and impair recovery in people with chronic pain and fatigue.

In this video, I break down why healthy fats are essential for chronic pain treatment and what this means for your nutrition strategy.