Dr Natalie Ledbetter

12/21/2025

Lately, I’ve been loving this combo for deep, restorative sleep:
✨ Magnesium L-threonate
✨ Apigenin
✨ Phosphatidylserine

This trio helps:
• quiet brain noise
• calm the nervous system
• lower nighttime cortisol
• support better sleep architecture

It doesn’t knock you out.
It helps your body feel safe enough to rest.

If you wake too early or feel wired at night, this is worth exploring.
Always start low and listen to your body. 💛

12/18/2025

We love our community! One of the top indicators for Longevity is having a close knit community. We are so abundant in that area.

2,816 Followers, 1,187 Following, 1,550 Posts

12/16/2025

Sleep isn’t always about hormones.
Sometimes it’s about calming the nervous system.

Last night I shared two gentle sleep tools I use and recommend:
• Microdosing ketone esters before bed
• Using amber light in the evening

A very small dose of ketone esters can help stabilize blood sugar and calm nighttime adrenaline.
Amber light tells your brain it’s dark and safe to rest.

No heavy sedatives.
No forcing sleep.
Just better signals to the brain.

If you wake up tired but wired, these are worth trying.
Let me know how you sleep 🌙

12/15/2025

This is my kind of busy! ❤️😍😎

12/15/2025

If your body is tired but your brain won’t slow down, this is for you.

These are three simple sleep hacks I use and recommend:
• Deep nasal breathing
• Mouth taping
• A small dose of polyphenols before bed

They help calm the nervous system.
They support deeper sleep.
And they are gentle, not sedating.

Sleep issues aren’t always about hormones.
Often, it’s about feeling safe enough to rest.

Try one tonight.
Or try all three.
Let me know how you sleep. 💛

12/13/2025

Feeling more tired, flat, or unmotivated lately… even though “nothing is wrong”?

It might not be you.
It might be Seasonal Affective Disorder (SAD).

Less daylight = less serotonin, dopamine, and energy.
Your nervous system notices — even if your calendar doesn’t.

The good news?
This is very fixable.

At Upgrade Labs, we use science-backed tools to support your brain, hormones, and nervous system during darker months:
• Light therapy
• Cold exposure
• Nervous system re-regulation
• Short, effective movement sessions

You don’t need to “push through.”
You need the right inputs.

If this season feels heavier than usual, let’s support your biology — not judge it.

✨ DM us or come see us at Upgrade Labs Fifth Street ✨

12/12/2025

Sleep can get harder in midlife.
But small changes can make a big difference.

Tonight, try these 3 new sleep hacks:
✨ Pink noise
✨ Warm → cool routine

These are easy.
They help calm your brain and support deep sleep.
Let me know how they work for you. 💛

12/11/2025

If you’ve ever taken a benzo to “help” your sleep and woke up feeling more tired, wired, or emotional the next day… there’s a reason.

Yes, benzodiazepines can help you fall asleep.
They can even keep you asleep for a few hours.
But what they don’t give you is the right kind of sleep.

They suppress REM.
They reduce deep sleep.
And the night after you take one, your brain often rebounds with tons of REM but almost no deep sleep — leaving you exhausted even if your sleep score looks “fine.”

Especially in perimenopause, when we already struggle with night wakings, cortisol swings, and declining deep sleep… benzos can make the underlying problem worse, not better.

Your sleep is too important to hand over to something that disrupts the architecture your brain and body need to heal.

There are better, safer, more effective ways to get real, restorative sleep. 💜✨

12/10/2025

Most women have never been taught that their estrogen breaks down into three main metabolites—and some are far more protective than others. The 2-hydroxy pathway? 💛 That’s your calm, clean-burning estrogen. The 4- and 16-hydroxy pathways? They can create heat, inflammation, and symptoms when they dominate.

And here’s the key:
The route of estrogen you choose (oral vs. transdermal) can shift which metabolites your body makes.

Your hormones aren’t just about levels…
they’re about pathways, detox capacity, and how your system handles stress.

The more you understand your biology, the more empowered you are to choose the safest, most effective hormone therapy for long-term health and longevity. 💜✨

12/09/2025

I know better yet I did it anyway!
Last night I took a Benadryl to help myself fall asleep — something soooo many perimenopausal women quietly do.
But here’s the truth: it feels like it helps, yet physiologically it can wreck the quality of your sleep, fragment REM, and leave you groggy, foggy, and more inflamed the next day.
This stage of life makes sleep tricky enough — we don’t need anything working against us.
If you struggle to fall asleep too, you’re not alone. 💛 Better tools and smarter biohacks are coming your way.

12/07/2025

I woke up feeling sad, heavy and discouraged. After a Depression Session in the Red Charger and prayers from I feel so much better! 💕🙏

12/05/2025

Nitric oxide is amazing…
but better at the right time. ⏰

Take it late in the day and you may lose deep sleep, run hot at night, or wake up too early.

✨ Take it in the morning.
✨ Avoid it at night.
✨ Let your supplements work with your nervous system, not against it.

Small timing shift. Big results. ❤️