04/26/2023
Interstitial Cystitis & Autoimmune Disorders
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๐นClinical associations have been found between IC and generalized autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and Sjogren's syndrome (SS) โฃ
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๐นCurrent research is lacking to demonstrate evidence of a causal role of an autoimmune pathogenesis. However, indirect evidence does support a possible autoimmune nature of interstitial cystitis. Clinical associations have been found between IC and generalized autoimmune diseases, such as ๐ฌ๐ฒ๐ฌ๐ญ๐๐ฆ๐ข๐ ๐ฅ๐ฎ๐ฉ๐ฎ๐ฌ ๐๐ซ๐ฒ๐ญ๐ก๐๐ฆ๐๐ญ๐จ๐ฌ๐ฎ๐ฌ (๐๐๐), ๐ซ๐ก๐๐ฎ๐ฆ๐๐ญ๐จ๐ข๐ ๐๐ซ๐ญ๐ก๐ซ๐ข๐ญ๐ข๐ฌ (๐๐) ๐๐ง๐ ๐๐ฃ๐จ๐ ๐ซ๐๐ง'๐ฌ ๐ฌ๐ฒ๐ง๐๐ซ๐จ๐ฆ๐ (๐๐) โฃ
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๐ธ๐๐ฃ๐จ๐ ๐ซ๐๐ง ๐ฌ๐ฒ๐ง๐๐ซ๐จ๐ฆ๐(๐๐ฌ) is an autoimmune disease that frequently affects the lacrimal gland and salivary gland causing the patient to have dry mouth and dry eyes. Genitourinary manifestation include frequency, urgency, and va**nal dryness have been reported but not extensively studied. In Ss, autoantibodies to the muscarinic M3 receptor on exocrine cells are important to the pathogenesis. Muscarinic M3 receptors are also expressed on detrusor smooth muscle cells, where they mediate cholinergic contraction of the urinary bladderโฃ
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๐ธPassive transfer of SS IgG with inhibitory anti-M3R activity has demonstrated to produce a paradoxical increase in contractile responses of detrusor strips to cholinergic stimulation. Cystometry of whole bladders revealed a corresponding decrease in bladder wall compliance and phasic detrusor contractions upon filling, replicating the urodynamic features of an overactive bladder.โฃ
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A clinical trial in China is currently under investigation to see if certain antimuscarinic medication helps resolve these urogynecologic symptoms.โฃ
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van de Merwe, Joop P. "Interstitial cystitis and systemic autoimmune diseases." Nature Clinical Practice Urology, vol. 4, no. 9, Sept. 2007, pp. 484