The Jackson Laboratory

The Jackson Laboratory Est. 1929, JAX is a non-profit scientific research institute specializing in genetics, genomics & mouse models of disease. www.jax.org Cancer. Diabetes.

Alzheimer’s. Heart Disease. Parkinson’s. The Jackson Laboratory (JAX) leads the search to cure diseases rooted in our DNA. We are an NCI-designated cancer center and an independent 501(c)3 nonprofit organization with over 90 years of experience in genetics and genomics research. JAX blends the brightest minds with state-of-the-art resources to accelerate discovery. Areas of Discovery (>60 Principal Investigators, >250 Ph.D.s, M.D.s, and D.V.M.s):
• Cancer: We are a National Cancer Institute designated Cancer Center focusing on cancer initiation, progression, prevention and therapies.
• Developmental/reproductive biology: birth defects, Down syndrome, osteoporosis, fertility
• Immunology: HIV-AIDS, anemia, autoimmunity, cancer immunology, immune disorders, lupus, transplant rejection
• Metabolic diseases: atherosclerosis, cardiovascular disease, diabetes, high blood pressure, obesity, microbiome
• Neurobiology: blindness, Parkinson’s, Alzheimer’s, deafness, epilepsy, glaucoma, macular degeneration, neurodegenerative diseases
• Neurobehavioral disorders: autism, addiction, depression

Supporting Global Research:
• The JAX Mouse Repository and Scientific Services are among the premier resources available for biomedical research. Committed to Education:
• Summer Student Program (undergrad & high school)
• Teaching the Genome Generation Short Course
• Ph.D. programs: U. Maine, Tufts University and U. Connecticut
• Courses, Conferences and Workshops

Support The Jackson Laboratory: https://www.jax.org/give-to-jax

12/19/2025

At a packed event on Wednesday in Manhattan, we officially "tied the ribbon" with The New York Stem Cell Foundation Research Institute. JAX and NYSCF officials, local politicians, and supporters came together to celebrate the symbolic joining of our two organizations — and the start of a new era in biomedical discovery.

Get the full story: go.jax.org/ribbon-tying

12/18/2025

Celebrating the biggest accomplishments from 2025, JAX Wrapped is here!

We're taking a look back at the moments that defined our year, from our acquisition of the New York Stem Cell Foundation to reaching more than 8,500 learners across the globe.

Join us in commemorating a fantastic year at JAX — what were some of your favorite highlights from the year?

12/17/2025

As the year comes to a close, we want to extend our appreciation to the entire JAX community. Your commitment to advancing science and improving human health drives meaningful progress every day.

Wishing you a wonderful holiday season and looking forward to continuing our work together in the year ahead.

12/17/2025

Developing new drugs is one of the riskiest and most expensive endeavors in science. JAX has announced a bold initiative to improve that trajectory.

Powered by an up to $30 million contract from Advanced Research Projects Agency for Health (ARPA-H), the project combines AI, stem cells, and genetic variation to predict drug safety before human trials.

Learn more: go.jax.org/cardioverse

🎥 Now on streaming, "The Zebra and the Bear" is an important documentary that chronicles Amber Olsen's extraordinary det...
12/16/2025

🎥 Now on streaming, "The Zebra and the Bear" is an important documentary that chronicles Amber Olsen's extraordinary determination: raising millions of dollars, forging research partnerships, and pushing the science forward to give her daughter, Willow, and other patients like her, a chance to beat the odds.

🦓 The film includes the story of how The Rare Disease Translational Center at JAX played a major role in Amber’s journey by conducting research into new treatments including gene therapy for the condition.

Amber Olsen’s quest to save her daughter from multiple sulfatase deficiency involved innovative research from The Jackson Laboratory that helped push gene therapy toward clinical trials.

The EndoRISE Fall Forum brought together global leaders, researchers, and advocates to accelerate progress in endometrio...
12/12/2025

The EndoRISE Fall Forum brought together global leaders, researchers, and advocates to accelerate progress in endometriosis research and care. Hosted by JAX, this collaborative event spotlighted groundbreaking science, patient-centered solutions, and the power of partnership to transform outcomes for millions living with endometriosis.

📰 Read the story: https://go.jax.org/ERForum2025

📼 View clips from the event in the comments ⤵️

🌐 Learn more about EndoRISE: www.ctendorise.org

Every year in the United States, nearly 800,000 people suffer from a stroke. For survivors, post-stroke symptoms can be ...
12/11/2025

Every year in the United States, nearly 800,000 people suffer from a stroke. For survivors, post-stroke symptoms can be devastating. Weakness or paralysis on one side of the body, balance and coordination problems, difficulties with speech, loss of vision, and trouble swallowing can plague stroke survivors for years, or even the rest of their lives.

In her lab at JAX, Assistant Professor Mary Teena Joy is studying exactly how the brain’s neural circuits change after a stroke—and the effects that has on stroke survivors. She hopes to identify precise, targeted therapies that could help restore some of the loss of function stroke survivors face every day.

In the Joy Lab at The Jackson Laboratory, researchers examine the neural pathways in the brain after a stroke, laying the groundwork for targeted therapies for recovery

Gretchen Clark's practical advice for seasonal affective disorder:🌅 prioritize morning light,📱 reduce nighttime screen u...
12/10/2025

Gretchen Clark's practical advice for seasonal affective disorder:
🌅 prioritize morning light,
📱 reduce nighttime screen use,
⏰ and maintain a consistent routine.

Clark, 2025 JAX Scholar, is exploring how circadian rhythms influence cellular aging—especially the behavior of senescent cells. Her work could unlock new strategies for healthy aging.

Watch her explain the science in this one-minute video:

cell senescence ↔️ circadian rhythms ↔️ aging and disease

Over 90% of drugs fail clinical trials, often because hidden cardiac risks appear late in the approval process after yea...
12/08/2025

Over 90% of drugs fail clinical trials, often because hidden cardiac risks appear late in the approval process after years of work and enormous costs. Thanks to an up to $30 million contract award from Advanced Research Projects Agency for Health, The Jackson Laboratory (JAX) aims to revolutionize drug safety testing with the CARDIOVERSE—a new project that combines , , and variation to predict before human trials.

New CARDIOVERSE project combines AI, stem cells, and genetic variation to predict drug safety before human trials.

Together, JAX and NYSCF combine strengths in genetics, stem cells and data science to accelerate discovery and deliver s...
12/05/2025

Together, JAX and NYSCF combine strengths in genetics, stem cells and data science to accelerate discovery and deliver solutions that will make a lasting difference for patients around the world. 🧬 🐁 🔬

Our organizations are joining forces to tackle some of the world’s greatest health challenges.

This  , you can help fuel breakthroughs for a healthier future with a gift to JAX. Your donations enable bold, high-impa...
12/02/2025

This , you can help fuel breakthroughs for a healthier future with a gift to JAX. Your donations enable bold, high-impact science that bring us closer to improved treatments and brighter outcomes for patients. There are no breakthroughs without you: https://go.jax.org/giving-tuesday

11/28/2025

The young scientists of today are unlocking the breakthroughs of tomorrow. At JAX, their work is crucial and their role in our community is unique. Hear more from them: https://www.youtube.com/watch?v=vXnf4LFhbAk

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Our Story

Cancer. Diabetes. Alzheimer’s. Heart disease. Parkinson’s... The Jackson Laboratory (JAX) leads the search to cure diseases rooted in our DNA. We are an independent 501(c)3 nonprofit organization with 90 years of experience in genetics and genomics research. In addition to 70+ research labs, we house many National Institutes of Health-funded Research Centers and have a rich curriculum of both in-person and online courses and workshops in genetics and genomics.

JAX has its mammalian genetics headquarters in Bar Harbor, Maine; a Genomic Medicine institute in Farmington, Conn.; and facilities in Sacramento, Calif., Ellsworth, Maine and Shanghai, China.

Areas of Discovery (>75 Principal Investigators, >250 Ph.D.s, M.D.s, and D.V.M.s): • Cancer: We are a National Cancer Institute (NCI)-designated Cancer Center focusing on cancer initiation, progression, prevention and therapies. • Developmental/reproductive biology: birth defects, Down syndrome, osteoporosis, fertility • Immunology: HIV-AIDS, anemia, autoimmunity, cancer immunology, immune disorders, lupus, transplant rejection • Metabolic diseases: atherosclerosis, cardiovascular disease, diabetes, high blood pressure, obesity, microbiome • Neurobiology: blindness, Parkinson’s, Alzheimer’s, deafness, epilepsy, glaucoma, macular degeneration, neurodegenerative diseases • Neurobehavioral disorders: autism, addiction, depression Supporting Global Research: • The JAX Mouse Repository and Scientific Services are among the premier resources available for biomedical research. • 2.5 million JAX® Mice are distributed annually to more than 900 institutions in 56 countries. Committed to Education: • Summer Student Program (undergrad & high school) • Teaching the Genome Generation Short Course • Ph.D. programs: U. Maine, Tufts University and U. Connecticut • Courses, Conferences and Workshops Support The Jackson Laboratory: https://www.jax.org/give-to-jax