The Jackson Laboratory

The Jackson Laboratory Est. 1929, JAX is a non-profit scientific research institute specializing in genetics, genomics & mouse models of disease. www.jax.org Cancer. Diabetes.

Alzheimer’s. Heart Disease. Parkinson’s. The Jackson Laboratory (JAX) leads the search to cure diseases rooted in our DNA. We are an NCI-designated cancer center and an independent 501(c)3 nonprofit organization with over 90 years of experience in genetics and genomics research. JAX blends the brightest minds with state-of-the-art resources to accelerate discovery. Areas of Discovery (>60 Principal Investigators, >250 Ph.D.s, M.D.s, and D.V.M.s):
• Cancer: We are a National Cancer Institute designated Cancer Center focusing on cancer initiation, progression, prevention and therapies.
• Developmental/reproductive biology: birth defects, Down syndrome, osteoporosis, fertility
• Immunology: HIV-AIDS, anemia, autoimmunity, cancer immunology, immune disorders, lupus, transplant rejection
• Metabolic diseases: atherosclerosis, cardiovascular disease, diabetes, high blood pressure, obesity, microbiome
• Neurobiology: blindness, Parkinson’s, Alzheimer’s, deafness, epilepsy, glaucoma, macular degeneration, neurodegenerative diseases
• Neurobehavioral disorders: autism, addiction, depression

Supporting Global Research:
• The JAX Mouse Repository and Scientific Services are among the premier resources available for biomedical research. Committed to Education:
• Summer Student Program (undergrad & high school)
• Teaching the Genome Generation Short Course
• Ph.D. programs: U. Maine, Tufts University and U. Connecticut
• Courses, Conferences and Workshops

Support The Jackson Laboratory: https://www.jax.org/give-to-jax

11/28/2025

The young scientists of today are unlocking the breakthroughs of tomorrow. At JAX, their work is crucial and their role in our community is unique. Hear more from them: https://www.youtube.com/watch?v=vXnf4LFhbAk

We are grateful for the incredible people who make our mission possible. From the patients and families who inspire us, ...
11/26/2025

We are grateful for the incredible people who make our mission possible. From the patients and families who inspire us, to the researchers, partners and supporters who fuel discovery, thank you for being part of the JAX community.

Together, we're advancing science and improving human health.

Search Magazine is a bi-annual publication from The Jackson Laboratory focused on research discoveries and human health....
11/25/2025

Search Magazine is a bi-annual publication from The Jackson Laboratory focused on research discoveries and human health.

Dive into our latest issue to read all about the JAX-NYSCF Collaborative and how we're building an integrated discovery platform with mice, stem cells, and big data to transform human health.

Search Magazine Fall 2025 A powerful alliance to accelerate the pace of discovery. The Jackson Laboratory & The New York Stem Cell Foundation

Mice pups conceived with   in the lab have slightly increased rates of DNA mutations, compared to pups conceived natural...
11/20/2025

Mice pups conceived with in the lab have slightly increased rates of DNA mutations, compared to pups conceived naturally, a new study suggests. The results do not directly apply to humans, but highlight the importance of understanding how fertility treatments affect an offspring’s DNA. 🧬🧪

While the results do not directly apply to humans, they highlight the importance of understanding how fertility treatments affect an offspring’s DNA.

11/19/2025

What does it take to turn a bold idea into a life-changing treatment? At JAX, innovation is more than progress — it’s the power to transform lives.

Discover how JAX scientists combine decades of expertise, advanced technology, and cutting-edge models to turn big ideas into real-world solutions. From precision medicine to new approaches for , , , and beyond, JAX is accelerating discoveries and expanding what’s possible in human health. Learn more at www.jax.org

Nearly 20 years ago, scientists discovered how to turn back the clock on cellular identity. By introducing a small set o...
11/14/2025

Nearly 20 years ago, scientists discovered how to turn back the clock on cellular identity. By introducing a small set of genetic factors critical for cell fate, they reprogrammed adult human cells into a flexible, early developmental state that can self-renew and differentiate into nearly any cell type. These cells, induced pluripotent stem cells (iPSCs), have reshaped how scientists around the world model and study disease.

Scientists at JAX and NYSCF are using patient-derived stem cells and genomic tools to transform disease modeling and accelerate cures.

How patient-derived stem cells and genomic tools are transforming disease modeling and accelerating cures

Genetic Counselors from JAX Clinical Education and The Maine Cancer Genomics Initiative (MCGI) are working hard to help ...
11/13/2025

Genetic Counselors from JAX Clinical Education and The Maine Cancer Genomics Initiative (MCGI) are working hard to help clinicians and care teams determine the right path for cancer patients.

Their work reaches the entire care pathway with advanced testing, expert education, and interpretation.

🔗 Read the full article: https://go.jax.org/connectingthedots

Today we recognize both Biomarker Awareness Day and Genetic Counselor Appreciation Day — two reminders of the essential roles biomarker testing and genetic counseling play in advancing precision oncology. More resources in the comments ⤵️

JAX has long been recognized as a global leader in biomedical research for its pioneering work in genetics, genomics and...
11/06/2025

JAX has long been recognized as a global leader in biomedical research for its pioneering work in genetics, genomics and the development of mouse models that have transformed our understanding of human disease. But JAX’s expertise doesn’t stop at the organismal level. JAX researchers are also at the forefront of advances in stem cells and cell modeling. 🧬

From stem cells that can become almost any cell type in the body, to AI-powered systems that analyze complex data, JAX researchers are accelerating the path from discovery to treatment — and shaping the future of precision medicine.

How JAX scientists are using stem cells to build better models, faster insights and smarter treatments.

Genomics is already transforming how doctors diagnose and treat patients, yet many health care providers graduate withou...
11/05/2025

Genomics is already transforming how doctors diagnose and treat patients, yet many health care providers graduate without formal genetics training. The Jackson Laboratory's Clinical Education team and the University of New England are working to change that.

The virtual Applied Genomics course blends foundational science, real-world case studies, and ethical discussions to prepare students for the future of precision medicine—before they even enter medical school.

JAX and the University of New England are preparing future health care providers for the era of precision medicine

11/04/2025

When her grandmother was diagnosed with Alzheimer’s disease, Kristen O’Connell saw firsthand how the illness reshapes identity, memory, and connection. Now, as a scientist at JAX, she’s leading research that brings us closer to preventing and treating this devastating condition.

10/31/2025

For nearly a century, JAX scientists have explored the genetic code to uncover the causes of disease and accelerate breakthroughs in medicine. From precision treatments to cutting-edge research models, JAX is turning bold ideas into real-world impact, improving outcomes for patients and families worldwide.

Join us as we reveal how JAX is shaping the future of medicine—one breakthrough at a time. Learn more at www.jax.org

We sat down with Daniel Paull, JAX's new vice president of discovery and platform development, to talk about the JAX-NYS...
10/30/2025

We sat down with Daniel Paull, JAX's new vice president of discovery and platform development, to talk about the JAX-NYSCF Collaborative, the importance of induced pluripotent stem cells, the future of precision medicine, and more.

Paull has spent his career at the intersection of biology and engineering. He oversees the NYSCF Global Stem Cell Array® and helped develop automation systems for generating iPSCs at unprecedented scale — advancing disease modeling and drug discovery. He leads NYSCF efforts to combine automation, imaging and AI to uncover hidden disease features.

Daniel Paull, who joins JAX from NYSCF as the vice president of discovery and platform development, has spent his career at the intersection of biology and engineering

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Our Story

Cancer. Diabetes. Alzheimer’s. Heart disease. Parkinson’s... The Jackson Laboratory (JAX) leads the search to cure diseases rooted in our DNA. We are an independent 501(c)3 nonprofit organization with 90 years of experience in genetics and genomics research. In addition to 70+ research labs, we house many National Institutes of Health-funded Research Centers and have a rich curriculum of both in-person and online courses and workshops in genetics and genomics.

JAX has its mammalian genetics headquarters in Bar Harbor, Maine; a Genomic Medicine institute in Farmington, Conn.; and facilities in Sacramento, Calif., Ellsworth, Maine and Shanghai, China.

Areas of Discovery (>75 Principal Investigators, >250 Ph.D.s, M.D.s, and D.V.M.s): • Cancer: We are a National Cancer Institute (NCI)-designated Cancer Center focusing on cancer initiation, progression, prevention and therapies. • Developmental/reproductive biology: birth defects, Down syndrome, osteoporosis, fertility • Immunology: HIV-AIDS, anemia, autoimmunity, cancer immunology, immune disorders, lupus, transplant rejection • Metabolic diseases: atherosclerosis, cardiovascular disease, diabetes, high blood pressure, obesity, microbiome • Neurobiology: blindness, Parkinson’s, Alzheimer’s, deafness, epilepsy, glaucoma, macular degeneration, neurodegenerative diseases • Neurobehavioral disorders: autism, addiction, depression Supporting Global Research: • The JAX Mouse Repository and Scientific Services are among the premier resources available for biomedical research. • 2.5 million JAX® Mice are distributed annually to more than 900 institutions in 56 countries. Committed to Education: • Summer Student Program (undergrad & high school) • Teaching the Genome Generation Short Course • Ph.D. programs: U. Maine, Tufts University and U. Connecticut • Courses, Conferences and Workshops Support The Jackson Laboratory: https://www.jax.org/give-to-jax