10/28/2025
PDRN IS GAINING POPULARITY LATELY & SHOWS GREAT PROMISE IN SKIN REJUVENATION! ALTHOUGH PDRN SEEMS NEW ITS ACTUALLY BEEN AROUND FOR A WHILE & FIRST STUDIED AFTER CHERNOBYL NUCLEAR DISASTER!
“While therapeutic journey of PDRN began with radiation-related treatments following the Chernobyl disaster in 1986, its uses have expanded far beyond this context. Early studies highlighted its ability to protect against radiation-induced lesions and promote tissue repair. More recent research has revealed its potential in various dermatological applications, including anti-aging, wound healing, acne scar treatment, melanogenesis inhibition, and hair regeneration.
At its core, PDRN works by stimulating collagen production, promoting angiogenesis (the formation of new blood vessels), and reducing inflammation. The molecular fragments of PDRN, which range from 250 to 1500 kDa, interact with purinergic receptors, driving essential tissue repair processes. Clinical studies have shown that when PDRN is administered intradermally, it accelerates wound healing, improves skin elasticity, reduces wrinkles, and even supports hair regrowth.”
“Although precise mechanism of action of PDRN is not known, it is used as a wound healing and anti-dystrophic agent with anti-inflammatory properties acting via reduction in cytokine levels.”
“PDRN generates nucleotides and nucleosides that can contribute to DNA formation, thus reactivating normal cell proliferation and growth pattern.”
“Additionally, PDRN may also protect cells from UV-induced DNA damage.”
“In the topical skincare realm, two key studies stand out: A 2004 study on skin graft healing showed that PDRN-treated wounds epithelialized faster (12.5 days vs. 24.45 days in the control group) and had fewer infections.”
SOURCES: https://brieflands.com/articles/jssc-159728
https://pmc.ncbi.nlm.nih.gov/articles/PMC5405115/
https://chemistconfessions.com/blogs/pdrn-skincare-hype-vs-reality
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