Seeking Health

11/22/2025

If histamine responses feel chaotic or not easy to manage regularly….

Histamine might be the reason—not the cause.😅

But why?

Your body processes histamine using two enzymes:
🔹 DAO – works in your gut (extracellular)
🔹 HNMT – works in your brain and cells (intracellular)

When these enzymes are underperforming—or “dirty”—histamine builds up. That’s when symptoms show up.

🧹But what dirties them?

• Gut inflammation or infections (SIBO, candida, mold)
• Nutrient deficiencies (think B2, B6, copper, methyl donors)
• Methylation dysfunction (especially MTHFR and low folate/B12)
• Estrogen excess or impaired detox pathways
• Environmental triggers like fragrances, EMFs, and mold

💢 Methylation Matters

HNMT needs methyl groups to support the breakdown of histamine.
Sluggish methylation? Histamine builds—no matter how clean your diet or how much DAO you take.

Clean MTHFR = normal methylation = healthy histamine.

🦠 Gut Comes First

DAO is made in your gut lining.
If your gut’s inflamed, DAO can drop—and histamine can rises.
Quercetin and DAO enzymes = symptom support*
But without gut repair, it’s a band-aid.🩹

Your takeaway 🫵

If histamine responses feel chaotic or not easy to manage regularly….
Start upstream.
Support flows downstream.
Order matters

📩 Comment LOOP if you want to explore where you are in this process and learn which nutrients to prioritize first.

New to Histamine?

Comment: HISTA instead 👀


*These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.

11/20/2025

Let's break it down...

The PEMT gene encodes an enzyme that converts choline into phosphatidylcholine (PC), a key compound required for:

✔️ Bile flow and gallbladder function
✔️ Liver detoxification and cholesterol export
✔️ Cell membrane stability
✔️ Methylation and epigenetic signaling

But here’s the key: PEMT activity is driven by estrogen.

And over 📊 70% of women carry a PEMT variant that impairs this process—especially under low estrogen conditions.

That’s a major issue for bile formation, detox, and hormone balance.😅

📉 When estrogen levels drop
• Perimenopause
• Postpartum
• Hormonal birth control withdrawal
• Low body fat or overtraining
• Endocrine-disrupting exposures
• Chronic under-eating

❗ PEMT expression falls → PC production declines → bile stagnates → detox slows.

This shift is particularly problematic in PEMT homozygous variants, where even normal estrogen fails to fully activate the pathway.

🔍 This explains the surge in:
• Gallstones during menopause
• Fatty liver
• Bile sluggishness postpartum
• Brain fog, estrogen dominance, and poor methylation

💬 Comment “PEMT” to explore whether you might carry this genetic variation, how to support PC production through recommendations and strategies to support PEMT without overburdening MTHFR.

Find the best vitamins & supplements, best probiotics, formulated by Dr. Ben Lynch just for you. Shop with Seeking Health® today!

11/17/2025

🥁 Drumroll, please… 🥁

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11/17/2025

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Find the best vitamins & supplements, best probiotics, formulated by Dr. Ben Lynch just for you. Shop with Seeking Health® today!

11/15/2025

Most people know tryptophan is the precursor to serotonin.🍗😄

But fewer realize that your body prioritizes tryptophan to make niacin (vitamin B3)—not serotonin. 👀

Why? 🧐

Because niacin is essential for over 400 enzymatic reactions, including energy production and DNA repair. When niacin is low, your body diverts 🔀 tryptophan toward niacin synthesis via the kynurenine pathway—😬 not the serotonin pathway.

Translation?

❗ Low niacin = low serotonin = low mood.

Symptoms of niacin deficiency look like symptoms of low serotonin.

Things like:
• Irritability/ apathy
• Cognitive sluggishness
• Persistent low mood
• Social withdrawal and loss of interest
• Non-rejuvenating sleep
• Poor concentration
• Skin (dermatitis) or GI issues

And if your serotonin is burned fast due to a fast MAOA gene, the impact can be more intense.

Fast MAOA rapidly breaks down neurotransmitters similair to COMT but with an emphasis on serotonin.

🤌 Your takeaway:
→ A small dose of Niacin + tryptophan = better serotonin support.*
→ If serotonin issues persist, consider a fast MAOA variation.

💛 Serotonin Nutrients
Formulated with essential cofactors and a ❗️precision dose of niacin—just enough to direct tryptophan toward serotonin synthesis without hijacking it for niacin production.*

💬 Comment “MAOA” to learn if fast serotonin breakdown could be your root issue—and how Serotonin Nutrients may help support you/how to use it with your protocol.


*These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.

11/11/2025

Folinic acid is finally getting the recognition it deserves.

📰 With FDA attention on prescription Leucovorin for neurodivergent support, more eyes are turning to folinic acid—the non-methylated folate your body already knows how to use.*

It’s not new—in fact, Seeking Health has offered folinic acid for over a decade.😮

Its versatility makes it a go-to for those with slow COMT/methylation sensitivities, and often the preferred form for long-term folate support.*

What about 5-MTHF (methylfolate)?🤔

Excellent for many. But not all. 👈 For sensitive individuals or those with slow COMT or MTHFR variants, it can overstimulate or lead to a “wired and tired” state.*

🥇Why Folinic Acid Wins

✔️ Methylation-Safe Support 💫
Folinic acid supports methylation without flooding your system with methyl groups. Ideal for those who feel off or irritable on 5-MTHF.*

✔️ Brain Access for Neuro Support 🧠
In cases like cerebral folate deficiency, folinic acid is the folate of choice. It bypasses blocked folate receptors and delivers support where it’s most needed: your brain.*

✔️ More Biochemical Range📈
Unlike 5-MTHF, folinic acid also supports:*
– DNA + RNA synthesis
– Neurotransmitter production (dopamine, serotonin)
– Biopterin recycling → crucial for nitric oxide and neurotransmitter function

Your takeaway 🫵

Folinic acid brings a broader foundation of support for everyone*
Ideal for slow COMT or methyl-sensitivity individuals *

💬 Comment: FOLINIC to explore our top-rated 🥇 Folinic Acid Lozenges or other formulas that include it—like B Complex MF.


*These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.

11/09/2025

Ready to go deeper into your genetic mood map?

Meet MAOA👋
COMT’s lesser-known, but also powerful, cousin.

Both genes 🧼 clear key neurotransmitters like dopamine, norepinephrine, and serotonin, heavily shaping your mood, focus, and stress response.

But while COMT works mostly in the prefrontal cortex (think focus, motivation, and estrogen metabolism)...

MAOA is your emotional regulator — managing the brain’s 👊 fight-or-flight 🏃chemistry.

🧠 MAOA’s job?

Break down neurotransmitters ❗after they’ve done their job.

That moment of calm after stress? That’s MAOA at work.😲

⚖️ MAOA vs. COMT: Similar Roles, Different Circuits

MAOA and COMT symptoms often mirror each other—but key differences matter:

🔹 MAOA plays a larger role in serotonin breakdown
🔹 It’s X-linked, meaning it works differently in men and women
🔹 MAOA symptoms often begin in childhood or adolescence (aggression, impulsivity, mood swings)
🔹 MAOA = externalizing symptoms: anger, antisocial behavior
🔹 COMT = internalizing symptoms: anxiety, overwhelm, mood instability

📌 Your Takeaway:

If you’re navigating mood challenges
❗ don’t stop at COMT. Look at MAOA.

MAOA sets the baseline tone for emotional regulation.
COMT adjusts your dynamic range for stress, cognition, and hormone balance through life.

And yes 🫢—these genes can interact.
When both are “dirty,” the risk for emotional dysregulation goes up—especially in sensitive or clinical populations.

💬 Comment “MAOA” to dive deeper into how to optimize fast or slow MAOA activity—and which supplements best support your unique brain chemistry.

Would you rather learn about COMT?

Comment: "COMT" 👀

11/07/2025

Cerebral folate deficiency (CFD) and Leucovorin (prescription folinic acid) are finally making news headlines 🗞️.

but...😬

The mainstream message is missing crucial distinctions.🔍

👇 Here’s the problem and why you should care:

Most conventional protocols jump straight to high-dose prescription leucovorin (aka folinic acid) without addressing the why.❓

Why isn’t folate getting into the brain?
What’s blocking its transport?
And why are so many still symptomatic—even on leucovorin?

💥 The real issue lies in folate transport—not folate quantity.

Even with “normal” blood levels, folate may never reach the brain if transport proteins or folate receptors aren’t working properly. That’s what defines cerebral folate deficiency—and it’s not limited to children or neurodivergent individuals....

Adults experience it, too.😦

Key culprits:
— 🐄 Dairy-triggered Folate Receptor Antibodies (FRAs)
— Elevated homocysteine
— Overexposure to synthetic folic acid

⚠️ Folic acid is not effective in the same way. Research suggests that it competes with naturally occurring folate forms at the blood-brain barrier. Avoid this always.

Folinic acid bypasses this blockade 🚧 ✅. It's the form your body can actually use, even when folate transport may be impaired.*

❗ Why folinic acid deserves your attention—regardless of diagnosis. It supports healthy:*

✓ Neurotransmitter production
✓ Biopterin recycling
✓ Brain methylation
✓ Mood, memory, and movement
✓ Slow COMT
✓ Methyl-free

🌱 If you’re supplementing with folate, choose forms your body recognizes:
✔️ Folinic acid
✔️ 5-MTHF (methylated)
❌ Never folic acid

💬 Comment: "FOLINIC" to explore our top-rated 🥇 Folinic Acid Lozenges or folinic acid–based formulas, find what fits your protocol, and learn more about different forms of folate.


*These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.

11/05/2025

DAO Enzyme support can feel like ✨magic—for a while.

You might have started to experience a healthy histamine response to food or exercise, and feelings of irritability are stable.

For some, that's all they need!👏

But for others it's deeper than that…

Suddenly, it comes back.
😵 You crash.
🥴 You react to high-histamine foods again.
🛑 DAO enzymes (Histamine Digest) “stopped working as well.”

But DAO didn’t fail—

Your body wasn’t ready to sustain it.

🚧 Why DAO Support Can Lose Steam Over Time

• Inflamed gut lining (Leaky Gut) → DAO production shuts down
• Low stomach acid → histamine builds upstream
• Missing cofactors (B6, copper, vitamin C) → DAO can’t activate
• Sluggish bile & low choline → DAO isn’t released into the gut

DAO helps buy time—it’s not always the fix.
❗You need to repair the terrain.

📩 Comment “LOOP” to uncover the functional order of healing—
Why gut health, methylation, histamine, and DAO Enzyme work better when stacked with the right root cause support.*

You’ll get insight into how to use our 🍴DAO Enzyme supplement (used to be called Histamine Digest) alongside other targeted nutrients through our⭐“ Suggested supplement combinations.”*

👉 Never tried a DAO supplement?

Comment “HISTA” instead to start learning about all things histamine.


*These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.

Support healthy histamine levels & histamine digestion with our patented DAO enzyme supplement. Eat & drink with confidence with DAO Enzyme!†

11/04/2025

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11/01/2025

Let's break it down…

🏦 Methyl groups: Created through methylation, constantly happening in the body (think MTHFR gene function).

💵 The PEMT gene: responsible for converting phosphatidylethanolamine into phosphatidylcholine (PC)—a process that burns through methyl groups.

Why does PEMT demand so many Methyl groups? 🤔

PEMT performs 3 sequential methylation reactions to produce PC. That means 3 SAMe molecules (your body’s universal methyl donor) are required ❗per molecule of PC made.

This makes the PEMT pathway a massive 💰methyl spender.

❓What does your PEMT control❓

1. 🫁 Bile fluidity and gallbladder function
Impaired PEMT activity = thick, sluggish bile, which increases risk of gallstones. In fact, PEMT dysfunction is directly linked to poor cholesterol export, gallstone formation, and poor estrogen clearance.

2. 🟡 Fat transport from the liver
When PC is low, fat accumulates in the liver—hello, fatty liver, poor detox, and gut health.

3. 🧫 Cell membrane integrity
Every cell in your body depends on healthy phospholipids to maintain structure and function.

Your Takeaway 🫵

Your MTHFR gene creates the methyl groups
Your PEMT, COMT, and HNMT (other genes) effect how they're spent.

💬 Comment “PEMT” to explore how to support this essential gene, why 🥇Optimal PC is our top supplement recommendation, and how it ties into gallbladder health and bile flow.

Want to learn more about how COMT, DAO and HNMT spend their methyl donors, let us know in the comments. 👀

10/30/2025

If histamine intolerance symptoms are dragging you down, one key question may lead to real progress:

Is it your gut—or your hormones—driving the overload? 🤔

🍴Gut-Driven Histamine Issues

Most histamine is produced and absorbed in the gut. If your DAO enzyme 🦠 (produced in your small intestine) is impaired, your ability to degrade dietary histamine plummets.

What can damage ⚠️ DAO and increase histamine absorption?

• SIBO or bacterial overgrowth
• Inflammation or food sensitivities (especially gluten and dairy)
• Nutrient deficiencies
• Mold, stress, or a microbiome imbalance

In the gut, DAO is king 👑. When it’s not working, histamine floods your system.

🩸 Hormone-Driven Histamine Surges

On the other hand, estrogen tells mast cells to release more histamine. And histamine, in turn, stimulates more estrogen—a vicious cycle 🔄.

This is why women 🙋‍♀️often experience:
• Worsened histamine symptoms mid-cycle (ovulation) and before menstruation
• PMS, migraines, endometriosis, or heavy periods when histamine is high

Hormone fluctuations during🤰 pregnancy also complicate things. In early pregnancy, DAO is low while histamine production (especially from the placenta) skyrockets. The result? Morning sickness is actually connected to histamine.

So Which One Is It?

💬 Comment “LOOP” to discover the functional order of healing — and how histamine connects to both estrogen and gut health issues. Start with your symptoms. We’ll help you identify the root cause and match you with the right supplement protocols for targeted support.

Want to know more about how pregnancy affects histamine?

Let us know in the comments 👀

Check out our Morning Sickness Guide: seekinghealth.com/pages/guides