02/20/2026
PRF Microneedling vs. PDGF, Let’s Clear This Up 💉✨
Not all collagen stimulation is created equal.
PRF uses your own blood to stimulate regeneration. It’s 100% natural and releases growth factors slowly over time. Beautiful for improving skin quality, under-eyes, and for patients who want an all-natural option.
PDGF is different.
It’s a purified, lab-derived growth factor that directly signals your cells to repair and build collagen. More precise. More controlled. Often faster visible improvement.
Here’s what most people don’t understand:
PRF only works as well as your biology allows.
Because it’s made from your own blood, your age, hormones, inflammation levels, nutrition, and overall health all impact the strength of your growth factors.
A healthy 30-year-old does not produce the same quality PRF as a stressed, inflamed, nutrient-depleted 50-year-old.
It’s not about the treatment failing.
It’s about cellular capacity.
That’s where PDGF can be a more consistent option because it doesn’t rely on your internal reserves.
Both work.
They just work differently.
PRF = regenerative + natural
PDGF = targeted + potent
The real question isn’t which is better.
It’s what is better for your skin goals.
Personally, I use both for micro-needling at least 3 to 4 times a year.