Jean Marc Sobczyk, MD, ND

02/14/2026

The ONE Supplement for MTHFR You Never Heard Of

PHOSPHATIDYLCHOLINE: The Methylation Game-Changer

We talk a lot about methylfolate and B12 for MTHFR support, but here's what nobody tells you: Two enzymes, PEMT and GAMT, consume a staggering 70% of all methylation reactions in your body.

Let me explain the mechanism:

Your PEMT gene uses precious methyl groups (that come from your limited methylfolate pool) to manufacture Phosphatidylcholine (PC).

What is Phosphatidylcholine? PC is a specialized phospholipid that forms the structural foundation of every single cell membrane in your body. It's absolutely critical for:

✅ Brain and nervous system function – PC is essential for myelin sheath integrity and neurotransmitter signaling

✅ Bile production – necessary for fat digestion and toxin elimination
✅ Liver health – PC transports triglycerides (VLDL) out of the liver, preventing Non-Alcoholic Fatty Liver Disease (NAFLD) 

✅ Cell membrane stability – maintains optimal cellular function and communication

Here's the clinical rationale:

When you have MTHFR mutations (especially homozygous C677T or compound heterozygous), your methylfolate production is already compromised. Yet your body is burning through 70% of available methyl groups just to make PC and creatine.

This creates a methylation bottleneck.

The Solution:

By supplementing with pre-formed Phosphatidylcholine, you bypass this massive methylation demand. This frees up your limited methylfolate pool for other critical functions:

Detoxification

Histamine metabolism

Neurotransmitter production

DNA repair

Glutathione synthesis

Who needs this most?

People with:

Homozygous PEMT + Homozygous MTHFR C677T

Compound heterozygous MTHFR (C677T/A1298C)

Intolerance to methylated B vitamins

Elevated homocysteine despite folate/B12 supplementation

Fatty liver disease (NAFLD)

Anxiety with MTHFR mutations

What happens when PC production drops?

When methylation slows down and choline becomes depleted:

Cell membrane and myelin instability occurs

Brain function becomes sub-optimal

Nervous system dysfunction develops

Homocysteine levels rise

Liver fat accumulation increases

02/04/2026

Got MTHFR? 🧬 5 Simple Ways to Support Your Body

Don’t let a genetic mutation slow you down! 🧬 

If you’ve discovered you have the MTHFR variant, it’s not a "diagnosis"—it’s just a manual for how to better care for your unique body. 

From swapping your vitamins to cleaning up your kitchen, these 5 steps help your body thrive.

Comment TOX to get my free Low Tox Living Guide on reducing your toxic burden! 🌿✨



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01/30/2026

MTHFR and THYROID ,
Why Methylfolate Is Not Working For You 

Most people think MTHFR is just about taking more Methylfolate. But if you have hypothyroidism, you might be missing the "spark plug" that makes it all work.

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You cannot activate your MTHFR enzyme without FAD (Flavin Adenine Dinucleotide).
⚡️ FAD is made from Riboflavin (B2).
⚡️ The conversion of B2 into activated FAD is dependent on Thyroid Hormone (T4).

If your thyroid is sluggish, your "active" B2 is low, and your MTHFR enzyme is essentially running on an empty battery, no matter how much folate you supplement.

Before you add more supplements, check the foundation.

👇 Comment the word BATTERY
below to get my free guide on the Thyroid/MTHFR connection and how to properly assess your B2 status.

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01/25/2026

01/18/2026

Stop taking Folic Acid immediately if you have anxiety."

 Most doctors will tell you Folic Acid is essential. As a board-certified MD and ND, I’m telling you it might be poisoning your methylation pathways.

If you have the MTHFR mutation (which 40% of you do), synthetic Folic Acid can block your receptors, leading to more anxiety, fatigue, and brain fog.

You don’t need Folic Acid. You need Methylated Folate (5-MTHF).

Stop guessing with your genetics.

Comment on the word GENE and I’ll send you my free guide on the 3 symptoms of MTHFR mutation.

01/13/2026

"I just can't think clearly anymore." if it sounds familiar, this is for you. 

 If you have MTHFR or think you might. 

 

And every time, we find the same thing: Undermethylation. 

When your MTHFR gene isn't functioning optimally, methylation suffers. 

And when methylation suffers, your brain pays the price first. 

Neurotransmitters like serotonin and dopamine? They require methylation. 

Cellular energy production? Methylation. 

Detoxification of metabolic waste? Methylation. 

This isn't "just getting older." This is fixable biochemistry. 

The solution isn't another cup of coffee. 

It's: → Methylated B vitamins → Supporting SAMe production → Lowering homocysteine → Optimizing mitochondrial function 

Brain fog is a symptom. 

Undermethylation is the root cause. 

Comment "CLARITY" to get my Methylation Cheat Sheet

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12/31/2025

How to Choose a Prenatal with MTHFR

🛑 STOP. Check your prenatal bottle right now.

If you carry the MTHFR variant (specifically C677T or A1298C), the standard prenatal advice does not apply to you. In fact, the "Folic Acid" found in 90% of generic multivitamins may be blocking the very receptors you are trying to nourish.

Here is the science breakdown:

🧬 1. The Folic Acid vs. Folate Trap Synthetic Folic Acid is not the same as Folate. To become usable, Folic Acid must go through a complex conversion process. If your MTHFR enzyme is downregulated (running at 30-70% capacity), you cannot efficiently convert synthetic acid. The result? A buildup of Unmetabolized Folic Acid (UMFA) in the blood [1, 3]. The fix: L-Methylfolate (5-MTHF). It bypasses the glitch entirely.

⚡️ 2. The Methylation Partners (B12 & B6) Folate pushes the methylation cycle, but B12 turns the gears. Synthetic B12 (Cyanocobalamin) requires energy to "detox" before use. The fix: Methylcobalamin [4]. It is bio-identical and ready to work immediately. Don’t forget: P-5-P (Active B6) for neurotransmitter synthesis.

🥚 3. Choline: The Metabolic Backup This is the most overlooked nutrient in pregnancy. Choline acts as a "secondary methyl donor." When folate pathways are sluggish due to MTHFR, Choline steps in to support placental function and infant brain speed [2]. The reality: Most prenatals have

12/13/2025

Does MTHFR increase miscarriage risk?

Yes, certain MTHFR variants can increase miscarriage risk 2-3x through elevated homocysteine that damages placental blood vessels and impairs critical methylation. However, this risk is highly modifiable with proper testing and methylated B vitamin protocols.

The key mechanism: MTHFR C677T and compound heterozygous variants reduce folate enzyme function, causing homocysteine accumulation. This damages developing placental vessels, increases microthrombi formation, and impairs DNA methylation needed for healthy fetal development.

What matters most isn't just your genetic variant—it's your functional homocysteine level. With proper testing (genetic + homocysteine + folate status), methylated B vitamin supplementation, and preconception optimization, most women with MTHFR variants go on to have healthy pregnancies.

Key action steps: 

→ Test homocysteine (target

11/16/2025

Plastics & Microplastics Are Impacting Your Fertility

Your water bottle might be sabotaging your fertility. 💧🚫

Swipe to discover how microplastics are accumulating in your reproductive organs—and 5 quick wins you can start THIS WEEK (slide 7! 👀)

Researchers found microplastics in 100% of human te**es and ovaries tested. This isn't just about the environment anymore—it's in YOUR body.

Both partners need to see this. 📍Save this post and share with someone on their TTC journey.

Which quick win are you starting tonight?

Drop it in the comments 👇

08/16/2025

MTHFR isn't a disease—it's a modifier. And that changes everything.

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Here's the uncomfortable truth about genetic testing: most healthcare professionals tell you not to test for MTHFR because "it doesn't change management." 

But here's what they're missing :knowledge can be the catalyst that finally motivates lasting change.

The psychology of genetic insight

We need to discuss MTHFR openly. If you've spent time in wellness circles, you've probably heard someone blame their fatigue, anxiety, or heart disease risk on this single gene variant. It's become genetics' most controversial player—and I understand the fascination.

MTHFR testing is accessible, results feel definitive, and having a biological "reason" can be profoundly motivating. 

The problem isn't the testing: it's the catastrophic misinterpretation that follows.

What the research actually shows

Cardiovascular disease is multifactorial and polygenic—dozens of genes plus environment shape your risk, not one variant. When researchers add polygenic risk scores (PRS) to standard tools, they identify significantly more people who later have cardiac events, especially younger patients. The lesson? Your genetic architecture matters, but it's the whole blueprint, not a single line.

MTHFR C677T: modifier, not destiny

Yes, the TT variant can nudge homocysteine levels up by reducing folate processing efficiency. But in our folate-fortified world, Mendelian randomization studies show that MTHFR-driven homocysteine elevation hasn't proven causally linked to cardiovascular disease or mortality.

This doesn't make MTHFR meaningless—it makes it context-dependent. In populations with poor folate status, TT variants do associate with higher stroke risk. Your genes set the stage, but nutrition and lifestyle write the script.

Why testing still matters (even when guidelines say it doesn't)

Here's where conventional medicine gets it wrong. Current guidelines don't recommend MTHFR genotyping for cardiovascular risk assessment—and they're technically correct. But they're missing the motivational power of personalized insight.

See more in the comlent

11/10/2024

DO YOU ALWAYS NEED SUPPLEMENTS FOR MTHFR?

Patients often see me or contact me online because they have discovered they have an MTHFR variant of their genes. Everyone asks me, "What supplements do I need to take, and how often?"

My answer is always the same: Your unique health concerns, symptoms, and lifestyle are the key factors we must consider. Your individuality is at the heart of our discussion.



Let's review several typical situations:

Case  #1️⃣ : You discover you have an MTHFR mutation but no symptoms. You are feeling well and have a healthy diet (eating a limited amount of processed food, plenty of fruits and veggies, and a small amount of fortified food); you exercise regularly, sleep 7-8 hours a night, and manage your stress well. We can still run some tests to ensure the methylation cycle is optimized, but you probably don't need any supplements.

Case  #2️⃣ : you have no symptoms of an MTHFR mutation but are considering adding a new member to your family. In this case, you will likely need to support your methylation cycle for optimal fertility and healthy pregnancy, as healthy eggs and healthy s***m require ample folate. Therefore, taking an additional small dose of folate along with your prenatal vitamins during the pregnancy would be best.

Case #3️⃣ : You are very active, an athlete, a child, and you experience a growth spurt. You will also likely need additional methylation support, and, of course, you will always consider optimizing your lifestyle as well.

Case  #4️⃣ : Your lifestyle is not optimal, and you have an MTHFR mutation. You need to improve your lifestyle and then add supplements on a case-by-case basis. You must also consider additional testing (B12, Folates, Vitamin D, Homocysteine, and other markers) to help refine your treatment plan.

Case  #5️⃣ : If you are sick and carry an MTHFR mutation, the most common situation, addressing your lifestyle, potential nutritional deficiencies, and supporting methylation with supplements, is paramount to treating the root cause of your disease.

▶️ Methylation support supplements can help but are not always needed. Also, don't always trust computer-based reports.

10/12/2024

THYROID HEALTH AND MTHFR

Did you know that Thyroid and MTHFR are interconnected?

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On the one hand, MTHFR needs T4 to function; on the other hand, the Thyroid gland needs Methylfolate to make T4.

Were you aware that an estimated 20 million Americans have some form of thyroid disease? Up to 60 percent of those with thyroid disease are unaware of their condition. More than 12 percent of the U.S. population will develop a thyroid condition during their lifetime.

If the thyroid gland functions slowly, you have a sluggish, slow MTHFR enzyme, even if you don’t have an MTHFR variant.

What is the mechanism, the connection between MTHFR and Thyroid Health?

The thyroid gland produces a hormone: T4, named thyroxine.

Thyroxine is needed to convert Vitamin B2 (Riboflavin) into its active form: FAD (Flavin Adenine Dinucleotide). This conversion is necessary.
The MTHFR enzyme must have enough supply of Active Vitamin B2 (FAD) to function. Therefore, the MTHFR enzyme slows down if FAD levels are low due to low thyroxine levels.
When MTHFR is slowing down, a lower amount of Methylfolate (active folate) is available. As a result, it impairs the body’s abilities to heal, detox and reduces the synthesis of SAMe.
SAMe is essential for neurotransmitters balance, estrogen metabolism, and histamine metabolism, AND Thyroid hormone synthesis!

Where do we find Riboflavin (B2)?

Dietary sources of vitamin B2 include Broccoli, Asparagus, Brussel sprouts, salmon, eggs, almonds, and milk.

Other necessary nutrients for the Thyroid

Magnesium, Iodine, Selenium, Zinc, and Tyrosine. Tyrosine is an amino acid (a building block for proteins) necessary for optimal thyroid function.

FYI: A paleo-type diet (often used as a therapeutic diet for a wide range of health conditions) may harm your Thyroid as it will decrease the intake of riboflavin since most processed foods and grains are avoided (sources of B2)

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