USC Center For Personalized Brain Health

02/11/2026

Who may benefit from ketosis—and who should be cautious?

➡️ In his latest Substack, Dr. Hussein Yassine, Director of the USC Center for Personalized Brain Health, unpacks the science behind ketosis as a brain-fuel strategy and weight-loss tool — with a special lens on individuals carrying the APOE ε4 gene variant and those at risk for cognitive decline. He explores when ketosis may be metabolically helpful and when it might pose risks, especially in older adults with low BMI or existing cognitive impairment.

Read and subscribe!
https://www.yassinelab.org/p/ketosis-weight-loss-and-the-apoe

A 70-year-old man came for a second opinion on optimizing brain health.

02/09/2026

So exciting to hear President Beong-Soo Kim highlight our team’s Alzheimer’s drug development work at the State of the Union! 🧠 Proud of this impactful research and its promise for advancing treatments. Fight On! ✌️ 💛❤️

USC NEWS:
https://mann.usc.edu/news/usc-scientists-identify-promising-new-target-for-alzheimers-linked-brain-inflammation/

PUBLICATION:
https://www.nature.com/articles/s44386-025-00035-0

Follow USC Center For Personalized Brain Health.

01/08/2026

ICYMI:

Merry Christmas, everyone.

01/08/2026

To learn more about the Keck Medicine of USC Prevention Clinic, please visit: https://keck.usc.edu/cpbh/prevention-clinic/.

12/09/2025

Empowering the Brain Health Community with high-quality insights from our research team. 🧠🧬

Join our Newsletter Community:

https://keck.usc.edu/cpbh/newsletter/

From personalized brain health to real-world innovation, this community is where bold ideas meet translational impact.

12/03/2025

In the PISCES trial, 1,228 adults on long-term hemodialysis in Canada and Australia were randomized to receive either 4 grams per day of fish oil (1.6 g EPA + 0.8 g DHA) or a corn-oil placebo for 3.5 years. The primary endpoint—a composite of cardiac death, nonfatal myocardial infarction, stroke, ...

11/01/2025

Diabetes may make the brain’s cortex thinner, which is a risk factor for Alzheimer’s and dementia. Dr. Meredith Braskie shares her latest research on brain health, diabetes, and population impact.
Comment VIDEO for link to the full interview.

10/28/2025

Dr. Meredith Braskie discusses cognitive testing as a clinical tool for determining cognitive impairment-- such as tests of memory or tests of planning and executing tasks. Looking at changes in cognitive testing over time can be especially helpful for identifying impairment.
Comment RESEARCH for links to research highlights at CPBH.

10/23/2025

🧠 Alzheimer’s disease is associated with changes in the brain, including amyloid plaque deposition, tau neurofibrillary tangles, and brain atrophy. How can you protect your brain from Alzheimer’s? Dr. Meredith Braskie discusses lifestyle factors known to support vascular and metabolic health—such as regular physical activity and balanced nutrition— that also contribute to brain resilience and may reduce the risk of cognitive decline.

To learn more about evidence-based strategies for promoting brain health, comment “BRAIN” or send us a direct message to receive our latest newsletter on lifestyle interventions and cognitive resilience.

09/30/2025

✨ We are excited to share the September 2025 edition of the USC Center forPersonalized Brain Health newsletter! This month, we explore how Ultra-Processed Foods (UPFs) drive overeating and impact brain health and share simple, science-backed tips for adopting a whole foods, brain-healthy diet.

👉 Don’t miss future issues! Subscribe to our newsletter today and stay informed with the latest research, insights, and practical steps for preserving brain health and preventing dementia.

📩 Read here:https://keck.usc.edu/cpbh/wp-content/uploads/sites/154/2025/09/SEPTEMBER-2025-NEWSLETTER-USC-MONTHLY.pdf
🔗 Or click the link in bio

Thank you for being part of our growing community your support drives our mission to protect and preserve brain health !!

USC Center for Personalized Brain Health Newsletter Give Now Home Mission Our Team Director Faculty Research Biomarker Discovery Drug Development Imaging Innovations Digital Tools for Early Detection Research Highlights Study Enrollment Hub USC GeneScreen USC Alzheimer’s Disease Research Center Pr...

09/10/2025

Make a whole-foods kitchen doable and affordable.
• Cut sugary drinks → water or unsweetened iced tea
• Swap processed red meats → fish, chicken, beans, lentils, nuts
• Add fiber-rich foods → fruits, veggies, legumes, whole grains

Budget helpers: beans/lentils, oats, frozen veggies, seasonal fruit, brown rice/barley/quinoa, eggs, canned fish, whole chicken, nuts/seeds.

Family tips: batch-cook once/use twice, involve kids in simple prep, season generously (herbs/spices = satisfaction).

Drop your favorite budget+ brain-smart swap below . 👇

09/06/2025

Ultra-processed foods can blunt satiety signals and push overeating. The fix is less industrial processing, more real food. Lose the extra calories and additives gain more fiber, more micronutrients, and more antioxidants.

🧠 Which brain-boosting swap are you trying this week?
👇 Share your favorite swaps!



Subscribe to the USC Center for Personalized Brain Health newsletter to learn more about nutrition and lifestyle for brain health and dementia prevention:
➡️ https://keck.usc.edu/cpbh/newsletter/
☎️ For Prevention Clinic appointments, please call (323) 442-6845

✅For APOE4 carriers and those with a family history of Alzheimer’s, long-term brain health is best supported by an early intervention that includes sustainable long term lifestyle changes such as a diet rich in fibers, good fats and nutrients, regular physical activity, quality sleep, and maintaining overall metabolic health.