Lado Healing Institute

Lado Healing Institute My name is Dr. Leonard A. Lado, MD, Founder & Medical Director of Lado Healing Institute and I would

12/27/2025

Why Treatment Resistance in Psychiatry May Be a Biological Signal — Not a Clinical Failure

One of the most persistent challenges in psychiatry is treatment resistance.
Despite adequate dosing, duration, and adherence, a substantial subset of patients with depression, schizophrenia, and OCD fail to respond meaningfully to standard treatments.

An expanding body of evidence suggests this is not simply a matter of “refractory illness,” but rather a biologically distinct subgroup characterized by:

• Elevated inflammatory markers (CRP, IL-6, TNF-α, IL-1β)
• Excessive oxidative stress and impaired antioxidant defenses
• Disrupted neuroplasticity and altered brain circuitry
• Reduced responsiveness to monoamine- and dopamine-focused therapies

Inflammation and oxidative stress can shift tryptophan metabolism, amplify glutamatergic signaling, activate microglia, and interfere with synaptic remodeling — creating a neurobiological environment where conventional treatments operate at a disadvantage.

This reframes treatment resistance not as noncompliance or therapeutic failure, but as a mismatch between biology and intervention.

The clinical implication is precision:
measure → stratify → target biology rather than repeating identical algorithms.

I discuss this framework in the accompanying video and will follow with practical discussions on biomarkers, phenotyping, and rational augmentation strategies for treatment-resistant patients.

📹 Video below





12/25/2025

What we often call imperfection may be the universe’s greatest design.

Gravity itself exists because of inequality—because distances were not perfect. If everything were equal, balanced, and flawless, nothing would move. No orbits. No motion. No creation. No life.

It was the imperfect distance between bodies that allowed them to pull toward one another, to circle, and to evolve. Perfection would have meant stillness. Nothingness.

In this way, imperfection carries a kind of divine authority. It is not a flaw—it is a force of nature.

So listen to it. Embrace it. In yourself and in others.
Because just like gravity, imperfection is what brings things—and people—together.

— Lado, 2025






Growth
Connection
ScienceAndLife
Wisdom
Neurophilosophy

What we often call imperfection may be the universe’s greatest design.Gravity itself exists because of inequality—becaus...
12/24/2025

What we often call imperfection may be the universe’s greatest design.

Gravity itself exists because of inequality—because distances were not perfect. If everything were equal, balanced, and flawless, nothing would move. No orbits. No motion. No creation. No life.

It was the imperfect distance between bodies that allowed them to pull toward one another, to circle, to evolve. Perfection would have meant stillness. Nothingness.

In that sense, imperfection carries a kind of divine authority. It is not a flaw—it is a force of nature.

So listen to it. Embrace it. In yourself and in others.
Because just like gravity, imperfection is what brings things—and people—together. LADO 2025

What we often call imperfection may be the universe’s greatest design.Gravity itself exists because of inequality—becaus...
12/24/2025

What we often call imperfection may be the universe’s greatest design.

Gravity itself exists because of inequality—because distances were not perfect. If everything were equal, balanced, and flawless, nothing would move. No orbits. No motion. No creation. No life.

It was the imperfect distance between bodies that allowed them to pull toward one another, to circle, to evolve. Perfection would have meant stillness. Nothingness.

In that sense, imperfection carries a kind of divine authority. It is not a flaw—it is a force of nature.

So listen to it. Embrace it. In yourself and in others.
Because just like gravity, imperfection is what brings things—and people—together.
LADO 2025

12/20/2025

After two years of focused research, I’m grateful to share that my manuscript examining the interplay between homeostasis, inflammation, and oxidative stress in neurodegenerative disease has been accepted for publication in Frontiers.

This work challenges the way we traditionally approach conditions like Alzheimer’s and Parkinson’s—often treating them after irreversible damage has already occurred.

The framework presented emphasizes:
• Early biological disruption of homeostasis
• Chronic inflammation and oxidative stress as upstream drivers
• Biomarkers as early warning signals
• Prevention-oriented, systems-based thinking rather than late-stage symptom control

The video you’re watching is a high-level summary of the concepts explored in the manuscript. I look forward to continued scientific dialogue as this work enters the broader research community.

⸻

Hashtags




12/15/2025

Psychiatry is often called a “low-success” specialty.
That claim doesn’t hold up to the data.

Most of medicine does not cure chronic disease.
We manage it. We prevent relapse. We restore function.

Psychiatry is no different—and in many ways, more impactful.

Evidence-based psychiatric care:
• Achieves meaningful remission in depression and anxiety
• Significantly reduces relapse in bipolar disorder and schizophrenia
• Improves what matters most to patients: sleep, relationships, work, and quality of life

Relapse is not failure.
Relapse is the biology of chronic illness—whether it’s blood pressure, glucose, or mood.

When psychiatric treatment works, it doesn’t just change symptoms.
It restores identity, autonomy, and the ability to live fully.

Psychiatry isn’t a dying field.
It’s a high-impact specialty for the future of medicine.

🎥 Watch the video for the data behind this perspective.

⸻

Hashtags



EvidenceBasedMedicine
QualityOfLife
ChronicDiseaseCare
FutureOfMedicine
MentalHealthEducation

12/11/2025

Proud to stand with an extraordinary team at Axiom Behavioral Health.

Under the leadership of Elaine, Ben, and Joseph, and with the dedication of every staff member—psychiatrists, nurses, therapists, social workers, and discharge planners—we provide care that truly changes lives.

We see our patients every day, and twice each week our entire multidisciplinary team meets with each individual to ensure their needs are met and that they have a stable place to go as they work to regain their lives.

No matter someone’s walk of life, no matter their background, no matter their challenges—we show up for them.
This is the heart of Axiom.
This is why we serve.
And I am honored to be part of this mission.

Psychiatry HealthcareLeadership CompassionInCare TraumaInformedCare AddictionRecovery PatientCenteredCare NaplesFlorida HealthcareProfessionals RestoringLives HopeAndHealing

11/24/2025

What if obesity is not what we think?

Today I’m sharing a perspective that bridges psychiatry, metabolism, and oxidative stress.
For years we’ve viewed obesity as a problem of willpower or calories. But emerging science tells a different story.

Obesity may actually be a redox-driven homeostatic disorder.
Meaning: chronic oxidative stress disrupts the circuits that regulate hunger, satiety, metabolism, and energy balance.

Here is the key insight:
It begins in adipose tissue but ends in the brain.

• Oxidative stress alters leptin, insulin, and adipokine signaling
• The hypothalamus becomes inflamed and stressed
• Satiety circuits weaken
• GLP-1 and incretin pathways become blunted
• Hunger increases even when the body doesn’t need food
• Energy expenditure drops

As a psychiatrist, I see this daily.
Some of the most effective psychiatric medications also worsen oxidative stress and metabolic syndrome.
We treat one problem but may worsen another.

I’m not claiming expertise in obesity research.
But I’ve spent years studying oxidative stress across many areas of medicine, and the patterns are impossible to ignore.

I’m sharing this to spark curiosity—and to encourage researchers who may want to explore this model further.
Because if obesity is truly a redox disorder, the future of treatment and drug development will look very different.

Psychiatry BrainHealth
Neuroscience GLP1 Incretins Mitochondria Inflammation
HealthcareInnovation MedicalScience Homeostasis
LadoHealingInstitute DrLeonardLado

11/23/2025

Fear, anxiety, and insomnia are three of the most powerful forces shaping emotional suffering and addiction today. Yet many people never learn the core truth: danger is real, but fear is not.
Fear is a thought. And thoughts have profound biological consequences.

Across spiritual traditions, humanity has been warned about the creative power of the mind:

“As a man thinks in his heart, so is he.” — Torah/Bible (Proverbs 23:7)
“In the beginning was the Word.” — Bible (John 1:1–3)
“Allah will not change the condition of a people until they change what is within themselves.” — Quran 13:11

Modern neuroscience now confirms what ancient wisdom always taught: thoughts activate biology.
Chronic fear drives cortisol, damages neurons in the hippocampus and prefrontal cortex, and disrupts memory, emotional regulation, and decision-making.
This is why fear leads to insomnia, panic, emotional instability, and ultimately addiction. People don’t reach for substances because they’re weak—they’re trying to silence fear taking over the nervous system.

In my practice, medication is used only to quiet the storm, to help the frontal lobe regain control so the brain can heal through neuroplasticity. But medication is not the cure.
Stillness, intention, prayer, meditation, and cognitive discipline are the real long-term therapies.

Psychiatry must evolve.
We need a model that integrates ancient wisdom with modern neuroscience, oxidative stress biology, and the science of consciousness.
That has been my mission for the past three to four years—connecting the dots so patients and professionals can finally see how healing truly works.

References:
Proverbs 23:7; John 1:1–3; Quran 13:11
McEwen (1999); Sapolsky (2000); Lupien et al. (2009); Arnsten (2009)
IQVIA Sleep Market Reports (2022–2024); CDC Sleep Statistics (2023)
Koob & Volkow (2016); Sinha (2008)
Tiller Conscious Acts of Creation; Davidson (PNAS 2004); Tang (2015)

FearAndAnxiety PsychiatristLife BrainHealing MindfulnessPractice MeditationHealing AddictionRecovery HealingThoughts BrainScience

11/13/2025

Phanquinone: A Forgotten Molecule With New Potential

Once explored as an anti-amoebic agent, phanquinone (4,7-phenanthroline-5,6-dione) has resurfaced in the scientific and patent literature for its possible role in memory enhancement and neuroprotection.

Early 2000s patents by P.N. Gerolymatos S.A. proposed phanquinone for improving learning, boosting memory, and even preventing cognitive decline in Alzheimer’s disease. Its activity as a redox-active molecule suggests it may influence key mechanisms involved in neurodegeneration:

• Enhanced cortical arousal and memory consolidation
• Antioxidant effects through redox cycling
• Modulation of metal ion imbalance (Cu²⁺/Zn²⁺), a known contributor to Alzheimer’s pathology

Despite its promise, peer-reviewed research remains limited, and no major clinical trials have followed. Still, its unique profile—combining metal chelation, antioxidant defense, and potential circuit-level effects—deserves renewed attention in today’s landscape focused on oxidative stress and mitochondrial dysfunction.

Sometimes, the overlooked molecules are the ones worth revisiting.

References:
Gerolymatos PN. US20030055078A1 (2003).
Gerolymatos PN. US6670369B2 (2003).
Gerolymatos PN. EP1007040B1 (2002).
Cummings JL et al., 2019.
Perry G et al., 2002.

11/10/2025

Truth doesn’t need a title.

When I published my paper in Frontiers (link in bio: https://www.frontiersin.org/), I learned that science is not about ego—it’s about humility.
Precision. Patience. Transparency.

Einstein was a patent clerk.
Mendel was a monk.
Karikó’s ideas were rejected for years.
And yet—they all changed the world.

Today, too many chase credit instead of truth.
But truth doesn’t care who finds it first—it only cares that it’s found.

The real prize in science is not being first.
It’s being right.
It’s sharing knowledge that helps humanity grow.

Science moves forward when ego steps aside.
And when we work from both the mind and the heart, the world changes for everyone.

10/26/2025

The Future of Mental Health Is Electric

For decades, psychiatry focused on chemistry — neurotransmitters, pills, and receptors.
Today, we’re discovering that healing the mind begins with restoring the brain’s circuits, not just balancing its chemistry.

At Lado Healing Institute, we bridge psychiatry and neuroscience — using transcranial magnetic stimulation, pharmacogenetics, and integrative medicine — to help the brain rebuild itself through neuroplasticity.

Every thought, emotion, and memory arises from energy, rhythm, and connection.
When those circuits are restored, healing becomes possible — not just symptom control.

This is the future of psychiatry — electrical, personalized, and transformative.

Address

9410 Fountain Medical Court Suite #200
Bonita Springs, FL
34135

Opening Hours

Monday 9am - 5pm
Tuesday 9am - 5pm
Wednesday 9am - 5pm
Thursday 9am - 5pm
Friday 9am - 5pm

Telephone

+12399484325

Website

Alerts

Be the first to know and let us send you an email when Lado Healing Institute posts news and promotions. Your email address will not be used for any other purpose, and you can unsubscribe at any time.

Contact The Practice

Send a message to Lado Healing Institute:

Shortcuts

Share

Share on Facebook Share on Twitter Share on LinkedIn
Share on Pinterest Share on Reddit Share via Email
Share on WhatsApp Share on Instagram Share on Telegram

Category

Welcome

My name is Dr. Leonard A. Lado, MD Founder & Medical Director of Lado Healing Institute. We are one of the largest independent psychiatry practices in Southwest Florida. Serving for over 17 years. I would like to thank the many patients who have shared their lives and taught me a great deal about medicine and psychiatry through their struggles and triumph. For more information visit our website www.ladomd.com.