11/24/2025
What if obesity is not what we think?
Today I’m sharing a perspective that bridges psychiatry, metabolism, and oxidative stress.
For years we’ve viewed obesity as a problem of willpower or calories. But emerging science tells a different story.
Obesity may actually be a redox-driven homeostatic disorder.
Meaning: chronic oxidative stress disrupts the circuits that regulate hunger, satiety, metabolism, and energy balance.
Here is the key insight:
It begins in adipose tissue but ends in the brain.
• Oxidative stress alters leptin, insulin, and adipokine signaling
• The hypothalamus becomes inflamed and stressed
• Satiety circuits weaken
• GLP-1 and incretin pathways become blunted
• Hunger increases even when the body doesn’t need food
• Energy expenditure drops
As a psychiatrist, I see this daily.
Some of the most effective psychiatric medications also worsen oxidative stress and metabolic syndrome.
We treat one problem but may worsen another.
I’m not claiming expertise in obesity research.
But I’ve spent years studying oxidative stress across many areas of medicine, and the patterns are impossible to ignore.
I’m sharing this to spark curiosity—and to encourage researchers who may want to explore this model further.
Because if obesity is truly a redox disorder, the future of treatment and drug development will look very different.
Psychiatry BrainHealth
Neuroscience GLP1 Incretins Mitochondria Inflammation
HealthcareInnovation MedicalScience Homeostasis
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